Page 14 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 5 ฉบับที่ 2
P. 14

ÒÒÚ   «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ°                              ªï∑’Ë ı©∫—∫∑’Ë Ú æƒ…¿“§¡ -  ‘ßÀ“§¡ Úıı



             radiation √–¥—∫µË” (BEIR VII-Phase 2)  π—∫ πÿπ„Àâ„™â LNT  »÷°…“«‘®—¬‡™‘ß≈÷°µàÕÕ’°¡“° √«¡∑—Èß°“√»÷°…“«‘®—¬„π¡πÿ…¬å

             model ‡À¡◊Õπ‡¥‘¡. π—Ëπ§◊Õ ∑’˧«“¡‡¢â¡¢âπÀ√◊Õ¢π“¥µË” §«“¡  °àÕπ∑’Ë®– “¡“√∂𔉪À≈—°°“√¢ÕߌÕ√凡 ‘ π’ȉªª√–¬ÿ°µå„™â
             ‡ ’ˬ߄π°“√‡°‘¥¡–‡√Á߬—ߧߡ’§«“¡ —¡æ—π∏å·∫∫‡ âπµ√ß°—∫  ‡ªìπ∑“߇≈◊Õ°„π°“√™–≈Õ§«“¡™√“·≈–¬◊¥Õ“¬ÿ„π§πµàÕ‰ª.
             ¢π“¥‚¥¬‰¡à¡’√–¥—∫°—Èπ.  √“¬ß“π‰¥â √ÿª«à“ À≈—°∞“π®“°°“√

             »÷°…“„π —µ«å∑¥≈ÕßÀ√◊Õ„π‡´≈≈å∑’Ë·π–«à“ ionizing radiation
                                                                ‡Õ° “√Õâ“ßÕ‘ß
             „π¢π“¥µË”¡’ª√–‚¬™πå À√◊Õ¡’√–¥—∫°—Èπ¢Õß°“√‡°‘¥Õ—πµ√“¬
                                                                 Ò. International Hormesis Society [homepage on the Internet]. Amherst
             ¬—߉¡àÀπ—°·πàπ‡æ’¬ßæÕ ·≈–„πªí®®ÿ∫—π¬—߉¡à¡’À≈—°∞“π‡æ’¬ß  (MA): International Hormesis Society. [cited 2007 Jul 17]. Available
                                                                    from: http://www.hormesissociety.org/
             æÕ∑’Ë®– π—∫ πÿπ¢âÕ ¡¡µ‘∑’Ë«à“√—ß ’„π¢π“¥µË”‚¥¬ ÿ∑∏‘·≈â«¡’
                                                                 Ú. Merck Source [homepage on the Internet]. Resource Library, Dorlandûs
                                                  ÒÙ
             ª√–‚¬™πåµàÕ ÿ¢¿“殓°ŒÕ√凡 ‘ ¡“°°«à“º≈‡ ’¬ .           Illustrated Medical Dictionary. Whitehouse Station (NJ): Merck & Co.,
                                                                    Inc. [cited 2007 Jul 17]. Available from: http://www. mercksource.com/
                  ”À√—∫ŒÕ√凡 ‘ ‡§¡’°Á‡™àπ‡¥’¬«°—π ·¡â«à“®–¡’√“¬ß“π«à“
                                                                    pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocsz SzuszSzcommonz
             ¡’ “√À≈“¬™π‘¥∑’Ë„π¢π“¥µË” ∑”„À⇰‘¥ª√“°Ø°“√≥åŒÕ√凡 ‘   SzdorlandszSzdorlandzSzdmd-a-b-000zPzhtm
                                                                 Û. International Hormesis Society [homepage on the Internet]. Amherst
             „π —µ«å∑¥≈Õß, ·µà√“¬ß“π¢Õß NAS/NRC ‡¡◊ËÕæ.». ÚıÙÚ
                                                                    (MA): International Hormesis Society. [cited 2007 Jul 17]. Available
              √ÿª«à“¬—߉¡à¡’‡Àµÿº≈∑’ËÀπ—°·πàπæÕ∑’Ë®–„™â·∫∫®”≈ÕߢÕß  from: http://www.hormesissociety.org/figures/schulz.htm
                                                                 Ù. International Hormesis Society [homepage on the Internet]. Amherst
             §«“¡‡ ’ˬ߄π°“√‡°‘¥¡–‡√Áß®“° “√‡§¡’√Ÿª·∫∫Õ◊ËππÕ°‡Àπ◊Õ®“°
                                                                    (MA): International Hormesis Society. [cited 2007 Jul 17]. Available
             LNT model, ‚¥¬¬°µ—«Õ¬à“ߢâÕ¡Ÿ≈∑“ß√–∫“¥«‘∑¬“¢Õß°“√      from: http://www.hormesissociety.org/figures/hueppe.htm
             °àÕ¡–‡√ÁߢÕß “√ÀπŸÕπ‘π∑√’¬å „π¢π“¥µË”À≈“¬√“¬ß“𠇪ìπ  ı. Wikipedia, the free encyclopedia [homepage on the Internet]. Arndt-
                                                                    Schulz rule. [cited 2007 Sep 10]. Available from: http://en.wikipedia.org/
                                           ÒÙ
             ¢âÕ¡Ÿ≈Àπ÷Ëß∑’Ë π—∫ πÿπ·∫∫®”≈Õß LNT .
                                                                    wiki/Arndt-Schulz_rule
                 ·¡â«à“ªí®®ÿ∫—πŒÕ√凡 ‘ ®–¬—߉¡à¡’∫∑∫“∑µàÕ°“√‡ª≈’ˬπ-  ˆ. International Hormesis Society [homepage on the Internet]. Amherst
                                                                    (MA): International Hormesis Society. [cited 2007 Jul 17]. Available
             ·ª≈ß°Æ√–‡∫’¬∫∑’Ë„™â§«∫§ÿ¡ª√‘¡“≥¢Õß “√‡§¡’„πÕ“À“√
                                                                    from: http://www.hormesissociety.org/figures/southam.htm
             À√◊Õ ‘Ëß·«¥≈âÕ¡ ·µàªí®®ÿ∫—π·π«§‘¥‡√◊ËÕߌÕ√凡 ‘ ‰¥â¡’  ˜. Fukushima S, Kinoshita A, Puatanachokchai R, Kushida M, Wanibuchi
                                                                    H, Morimura K. Hormesis and dose-response-mediated mechanisms
             ∫∑∫“∑Õ¬à“ß ”§—≠„π°“√»÷°…“«‘®—¬«‘∏’°“√™–≈Õ§«“¡™√“
                                                                    in carcinogenesis: evidence for a threshold in carcinogenecity of non-
             ‚¥¬Õ“»—¬·π«§‘¥∑’Ë«à“°“√„À⇴≈≈å·≈– ‘Ëß¡’™’«‘µ‰¥â‡º™‘≠°—∫  genotoxic carcinogens. Carcinogenesis 2005;26:1835-45.
                                                                 ¯. Raloff J. Counterintuitive Toxicology. Increasingly, scientists are finding
             §«“¡‡§√’¬¥πâÕ¬ Ê ®–∑”„À⇰‘¥°“√ª√—∫µ—«·≈–µÕ∫ πÕß
                                                                    that they canût predict a poisonûs low-dose effects. Science News
             ·∫∫ŒÕ√凡 ‘ ∑’ˇªìπª√–‚¬™πåµàÕ‡´≈≈å·≈–√à“ß°“¬ ‚¥¬‰ª    Online [serial on the Internet]. 2007 Jan 20. [cited 2007 Sep 9];
                                                                    171(3): [about 14 p.]. Available from: http://www.sciencenews.
             °√–µÿâπ°√–∫«π°“√∑“ß™’«‡§¡’À≈“¬Õ¬à“ß∑’˙૬´àÕ¡·´¡·≈–
                                                                    org/articles/20070120/bob8.asp
             µàÕµâ“π°“√‡ª≈’ˬπ·ª≈ßµà“ß Ê ∑’Ë∑”„À⇰‘¥§«“¡·°à ‡™àπ °“√  ˘. Wikipedia, the free encyclopedia [homepage on the Internet]. Radiation
                                                                    hormesis. [cited 2007 Sep 10]. Available from: http://en.wikipedia.org/
             ‡æ‘Ë¡§«“¡ “¡“√∂¢Õ߇´≈≈å„π°“√µâ“πªØ‘°‘√‘¬“ÕÕ°´‘‡¥™—π,
                                                                    wiki/Radiation_hormesis
             ´÷Ëߢ≥–π’È¡’À≈—°∞“π∑“ß«‘∑¬“»“ µ√åÀ≈“¬√“¬ß“π®“°°“√  Ò. Schor J. Radiation Hormesis: Magic Stones and Cancer, Part One.
             »÷°…“„π‡´≈≈åÀ√◊Õ —µ«å∑¥≈Õß· ¥ß„Àâ‡ÀÁπ«à“°“√‰¥â√—∫      Naturopathy Digest [serial on the Internet]. 2007 Aug. [cited 2007
                                                                    Sep 9]. Available from: http://www.naturopathydigest.com/archives/
             §«“¡‡§√’¬¥πâÕ¬ Ê ´È” Ê °—π®–™à«¬™–≈Õ§«“¡™√“·≈–¬◊¥
                                                                    2007/aug/schor.php
             Õ“¬ÿ —µ«å∑¥≈Õ߉¥â. µ—«Õ¬à“ߢÕß«‘∏’°“√∑’Ë∑”„À⇰‘¥§«“¡‡§√’¬¥  ÒÒ. Calabrese EJ, Baldwin LA. Defining hormesis. Hum Exp Toxicol
                                                                    2002;21:91-7.
             Õ¬à“ßÕàÕπ (stressor) ∑’Ëπ”À≈—°°“√ŒÕ√凡 ‘ ‰ªª√–¬ÿ°µå„™â„π
                                                                ÒÚ. Calabrese EJ, Baldwin LA. Hormesis as a biological hypothesis. Environ
             °“√«‘®—¬°“√™–≈Õ§«“¡™√“ ‰¥â·°à °“√ÕÕ°°”≈—ß°“¬, °“√„Àâ   Health Perspect 1998;106:357-62.
                                                                ÒÛ. Calabrese EJ, Staudenmayer JW, Stanek EJ 3rd, Hoffmann GR.
             §«“¡√âÕπ (heat shock), °“√©“¬√—ß ’, °“√„Àâ “√∑’Ë∑”„À⇰‘¥
                                                                    Hormesis outperforms threshold model in National Cancer Institute
             ªØ‘°‘√‘¬“ÕÕ°´‘‡¥™—π (prooxidant), °“√‡æ‘Ë¡·√ß‚πâ¡∂à«ß  antitumor drug screening database. Toxicol Sci 2006;94:368-78.
                                                          ˘     ÒÙ. Mushak P. Hormesis and its place in nonmonotonic dose-response
             (hypergravity) ·≈–°“√®”°—¥Õ“À“√·≈–·§≈Õ√’ ‡ªìπµâπ .
                                                                    relationships: some scientific reality checks. Environ Health Perspect
             ß“π«‘®—¬‡À≈à“π’Ȭ—ßÕ¬Ÿà„π√–¬–‡√‘Ë¡µâπ‡∑à“π—Èπ ®÷߬—ßµâÕß¡’°“√  2007;115:500-6.
   9   10   11   12   13   14   15   16   17   18   19