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J Thai Trad Alt Med Vol. 21 No. 3 Sep-Dec 2023 515

0.2% chlorhexidine mouthwash in complete thoxycurcumin, respectively, was dissolved in
eradication of both free-floating forms and a solvent solution prepared by mixing 40 ml of

biofilms of C. albicans and also enhanced polyethylene glycol (PEG), 25 ml of 2% low mo-
anti-inflammatory and ulcer healing activity lecular weight chitosan (Sigma Aldrich, USA)
[15]
of curcumin. Additionally, an alcohol free solution (chitosan 2 g in 100 ml of 1% acetic
0.1% chitosan-0.5% curcuminoids mouthwash acid water), 15 ml of sorbitol, 1 ml of paraben
(CHI-CUR) has been found to be better than concentration, and 100 µl of 10% NaOH (the
2% chlorhexidine mouthwash in management remaining volume was made up of water until

of generalized or candida-associated denture reaching 100 ml).
stomatitis with high safety and high patient
[16]
compliance and satisfaction. 1.2 Study participants
Therefore, the aim of this study was to Volunteers agreeing to participate in
determine the therapeutic efficacy of 0.1% the study signed the informed consent form.

CHI-CUR mouthwash that exerts anti-inflam- Protocol and consent forms were approved by
matory and antifungal activity in management the Research Ethics Committee (REC) of the
of oral lichen planus (OLP) in comparison to a Faculty of Dentistry, Prince of Songkla Univer-

standard 0.1% TA mouthwash to provide its sity (EC6112-48-J-HR). The trial number was
clinical application as an alternative therapeu- TCTR20200910005. The name of the registry

tic agent for OLP. is the Thai Clinical Trials Registry (TCTR).
Methodology The inclusion criteria were 18 years
aged or older adults of both genders with
1. Material pathological evaluations confirming symp-

1.1 Preparation of an alcohol-free 0.1% tomatic OLP by experienced oral medicine
chitosan-0.5% curcuminoids (CHI-CUR) specialists, having the ability to use mouth-

mouthwash by a pharmacist in the Depart- wash correctly and were treated at the Den-
ment of Clinical Pharmacy, Faculty of Phar- tistry hospital, Prince of Songkla University,
maceutical Sciences [16] Thailand.

0.1 g of commercial curcuminoids powder The exclusion criteria were pregnant and
purified from turmeric (Curcuma longa Linn.) lactating women; patients with open mouth

rhizome (Thai-China Flavors and Fragrances sores because of any other diseases; patients
Industry Co. LTD) containing 79:19:2 cur- with oral candidiasis, HIV infections or chronic
cumin: demethoxycurcumin and bisdeme- systemic disease (e.g. hyperthyroidism, dia-