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วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก Journal of Thai Traditional & Alternative Medicine
ปีที่ 21 ฉบับที่ 3 กันยายน-ธันวาคม 2566 Vol. 21 No. 3 September-December 2023

Original Article

Efficacy of 0.1% Chitosan-Curcuminoids Mouthwash in Treatment
of Oral Lichen Planus and Prevention of Disease Relapse

Sirima Mahattanadul *,¶,# , Kanokporn Pangsomboon , Mustafa Waqar Mian , Sureerat Chelae
†
‡
§
* Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University,
Kho Hong Sub-District, Hat Yai District, Songkhla 90110, Thailand
† Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Kho Hong Sub-District, Hat Yai District,
Songkhla 90110, Thailand
‡ Department of Pharmacy, Forman Christian College University, Pakistan.
§ Division of Clinical Microbiology, Department of Pathology, Faculty of Medicine, Prince of Songkla University,
Kho Hong Sub-District, Hat Yai District, Songkhla 90110, Thailand
¶ Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences,
Prince of Songkla University, Kho Hong Sub-District, Hat Yai District, Songkhla 90110, Thailand
# Corresponding author: sirima.m@psu.ac.th

Abstract
Introduction and Objective: The aim of this study was to determine the therapeutic efficacy of 0.1%
alcohol-free chitosan-curcuminoids mouthwash (CHI-CUR) which exerts anti-inflammatory and antifungal activity
in management of oral lichen planus (OLP) in comparison to a standard 0.1% triamcinolone acetonide mouthwash
(TA) to provide its clinical application as an alternative therapeutic agent for OLP.
Methods: A pilot single-blinded randomized controlled trial was conducted at the Faculty of Dentistry,
Prince of Songkla University, Thailand between February 2019 - April 2021. Participants were aged 18 years or
older with a confirmed diagnosis of OLP by an oral medicine practioner. Patients were randomly assigned to CHI-
CUR or TA mouthwash at a dose of five milliliters for two min, four times a day for four weeks. Primary outcome
measures include a complete relief of erythematous lesions, a reduction in the number of C. albicans colonies
present in the oral cavity and the disease relapse.
Results: The result showed within the 4-week treatment course, that from the patients in the mild/
marked erythema group, three of six patients (50%) using TA mouthwash and two of eight patients (20%) using
CHI-CUR mouthwash had a complete relief of erythematous lesions, whereas patients in the ulceration group
(where 3 patients used TA mouthwash and one patient used CHI-CUR mouthwash) had a decrease in site activ-
ity score level from 16 and 11 to 5 and 6 (mild/marked erythema), respectively. Both treatment groups provided
comparable efficacy in relief of pain or dryness of the oral cavity within the 2-week treatment course. For inhibi-
tory efficacy against candida colonization in the oral cavity, it was found at the fourth week after the treatment that

Received date 15/06/23; Revised date 24/10/23; Accepted date 13/12/23

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