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520 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก       ปีที่ 21  ฉบับที่ 3  กันยายน-ธันวาคม 2566




            Table 2  Treatment efficacy of OLP and anti-candida efficacy
            Outcomes                           Week 0                         Week 4
                                           TA       CHI-CUR    p       TA      CHI-CUR     p
                                        (n = 10)    (n = 9)         (n = 10)    (n = 9)
            Site activity score
              Non erosive
              reticular
              Median (min-max)             0          -        -    remission     -        -
                                         (n = 1)                     (n = 1)
              Mild/marked
               erythema                                             remission  remission  0.58
              Median                       4          6.5    0.15    (n = 3)    (n = 2)
               (min-max)                 (1-8)      (3-12)
                                         (n = 6)    (n = 8)         3 (0-11)   3 (0-7)   0.16
                                                                     (n = 3)    (n = 6)
               Ulceration
              Median                       11         16     0.99      5          6      0.75
              (min-max)                  (3-35)                      (1-36)
                                         (n = 3)    (n = 1)          (n = 3)    (n = 1)
            Pain (VAS: 0-10)             2 (0-9)    3 (0-7)   0.60     0          0        -
            Dryness                      1 (0-2)    1 (0-4)   0.69   0 (0-4)   0 (0-2)   0.64
            No of C. albicans
            Colonies (CFU/ml)          0.7 5 10  ±  1.2 5 10  ±  0.69  0.6 5 10  ±   0   0.04
                                                                          3
                                                         3
                                              3
            (Mean ± SE)                 0.4 5 10 3   1.2 5 10 3     0.2 5 10 3
                                         (n = 8)    (n = 7)          (n = 6)    (n = 7)
            TA = 0.1% triamcinolone acetonide mouthwash
            CHI-CUR = 0.1% alcohol-free chitosan-curcuminoids mouthwash
            Site activity score = Site score X Activity score.
            Site score: (0) no lesion at site; (1) less than 50% of area affected; (2) if greater than 50%, not defined anatomically
            Activity score: (0) normal; (1) mild erythema; (2) marked erythema; (3) ulceration
            p < 0.05 comparison of different mouthwash groups (Mann-whitney U test)




           CUR mouthwash had a complete anti-candida   had no detectable fungal colonization before
           response at 4 weeks of the  treatment course   using the intervention had a superinfection

           whereas 6 out of 10 (60%)  patients using TA   of C. albicans at 4 weeks of the treatment
           mouthwash still found a candida infection at   course. Disease relapse was not observed at
           4 weeks of the treatment course. Moreover, 2   the 6-month follow-up time in either interven-

           out of 10 patients using TA mouthwash who   tion group.
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