Page 37 - Acrobat J Trad-21-3-2566

520 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 3 กันยายน-ธันวาคม 2566

Table 2 Treatment efficacy of OLP and anti-candida efficacy
Outcomes Week 0 Week 4
TA CHI-CUR p TA CHI-CUR p
(n = 10) (n = 9) (n = 10) (n = 9)
Site activity score
Non erosive
reticular
Median (min-max) 0 - - remission - -
(n = 1) (n = 1)
Mild/marked
erythema remission remission 0.58
Median 4 6.5 0.15 (n = 3) (n = 2)
(min-max) (1-8) (3-12)
(n = 6) (n = 8) 3 (0-11) 3 (0-7) 0.16
(n = 3) (n = 6)
Ulceration
Median 11 16 0.99 5 6 0.75
(min-max) (3-35) (1-36)
(n = 3) (n = 1) (n = 3) (n = 1)
Pain (VAS: 0-10) 2 (0-9) 3 (0-7) 0.60 0 0 -
Dryness 1 (0-2) 1 (0-4) 0.69 0 (0-4) 0 (0-2) 0.64
No of C. albicans
Colonies (CFU/ml) 0.7 5 10 ± 1.2 5 10 ± 0.69 0.6 5 10 ± 0 0.04
3
3
3
(Mean ± SE) 0.4 5 10 3 1.2 5 10 3 0.2 5 10 3
(n = 8) (n = 7) (n = 6) (n = 7)
TA = 0.1% triamcinolone acetonide mouthwash
CHI-CUR = 0.1% alcohol-free chitosan-curcuminoids mouthwash
Site activity score = Site score X Activity score.
Site score: (0) no lesion at site; (1) less than 50% of area affected; (2) if greater than 50%, not defined anatomically
Activity score: (0) normal; (1) mild erythema; (2) marked erythema; (3) ulceration
p < 0.05 comparison of different mouthwash groups (Mann-whitney U test)

CUR mouthwash had a complete anti-candida had no detectable fungal colonization before
response at 4 weeks of the treatment course using the intervention had a superinfection

whereas 6 out of 10 (60%) patients using TA of C. albicans at 4 weeks of the treatment
mouthwash still found a candida infection at course. Disease relapse was not observed at
4 weeks of the treatment course. Moreover, 2 the 6-month follow-up time in either interven-

out of 10 patients using TA mouthwash who tion group.