Page 40 - Acrobat J Trad-21-3-2566

J Thai Trad Alt Med Vol. 21 No. 3 Sep-Dec 2023 523

the pain sensation during the treatment. It to be as effective as 0.1% TA mouthwash in
was also noticed in patients who had previ- managing the signs and symptoms of OLP
ously experience with TA mouthwash that the with a comparable time to remission state

pain resolving efficacy of TA in the oral paste and a comparable efficacy in relief of pain
preparation seemed to be less than that of the or dryness of the oral cavity. Nevertheless, a
mouthwash preparation. Another intervention complete anticandidal response was found
study with a smaller dose of curcuminoids only in patients using CHI-CUR mouthwash.
was conducted to compare the efficacy of 1% It was also found from the present study that

curcuminoids gel with 0.1% TA oral paste in 20% of patients treated with 0.1% TA had a
[14]
managing the signs and symptoms of OLP. superinfection of C. albicans at 4-weeks of the
The results revealed that the application of treatment. However, a disease relapse was

1% curcuminoids oral gel six times daily for 12 not observed at the 6 month-follow-up time
weeks was almost as effective as application in either intervention group in the present
of 0.1% TA oral paste thrice daily. study. The anti-inflammatory and anti-candida
Compared to other delivery systems, efficacies of CHI-CUR mouthwash obtained
mouthwash preparation is a common com- from the present study was consistent with

mercially available dosage form being used our previous clinical study in patients with
[16]
for a number of specific problems in the oral denture stomatitis and confirmed its poten-
cavity, especially in patients with widespread tial as a potent preventive and therapeutic

symptomatic erosions since the direct appli- agent against oral candidiasis. Due to the
cation of oral paste, cream or gel preparation bioadhesive, anti-candida, anti-inflammatory
is uncomfortable and adheres poorly to the and wound healing properties of chitosan [27-29] ,
moist mucous membrane. In patients with it can be extremely beneficial to maintain
widespread symptomatic lesions, TA mouth- the concentration of curcuminoids in an oral

wash is commonly used for controlling the cavity and enhance the therapeutic efficacy
symptoms of the disease. Nevertheless, about of curcuminoids. Avoiding the use of alcohol
11.4% of the OLP patients treated with 0.3% to dissolve curcuminoids in the mouthwash

or 0.5% TA mouthwash had been found to formulation is also crucial for a better clinical
[26]
have fungal superinfection. It had also been response and patient compliance. Considering
reported that 20% of OLP patients treated with the chronic nature of OLP, risk of oral candidia-
0.1% TA ointment for 4 weeks had recurrence sis upon usage of topical corticosteroids, and
of the disease during the follow up period of potential therapeutic benefits with the safety

6 months. In the present study, an alcohol profile of CHI-CUR mouthwash; a randomized
[6]
free 0.1% CHI-CUR mouthwash was found controlled trial with larger number of patients