Page 40 - Acrobat J Trad-21-3-2566
P. 40

J Thai Trad Alt Med                                    Vol. 21  No. 3  Sep-Dec  2023  523




            the pain sensation during the treatment. It   to be as effective as 0.1% TA mouthwash in
            was also noticed in patients who had previ-  managing the signs and symptoms of OLP
            ously experience with TA mouthwash that the   with a comparable time to remission state

            pain resolving efficacy of TA in the oral paste   and a comparable efficacy in relief of pain
            preparation seemed to be less than that of the   or dryness of the oral cavity. Nevertheless, a
            mouthwash preparation. Another intervention   complete anticandidal response was found
            study with a smaller dose of curcuminoids   only in patients using CHI-CUR mouthwash.
            was conducted to compare the efficacy of 1%   It was also found from the present study that

            curcuminoids gel with 0.1% TA oral paste in   20% of patients treated with 0.1% TA had a
                                                  [14]
            managing the signs and symptoms of OLP.     superinfection of C. albicans at 4-weeks of the
            The results revealed that the application of   treatment. However, a disease relapse was

            1% curcuminoids oral gel six times daily for 12   not observed at the 6 month-follow-up time
            weeks was almost as effective as application   in either intervention group in the present
            of 0.1% TA oral paste thrice daily.         study. The anti-inflammatory and anti-candida
                 Compared to other delivery systems,    efficacies of CHI-CUR mouthwash obtained
            mouthwash preparation is a common com-      from the present study was consistent with

            mercially available dosage form being used   our previous clinical study in patients with
                                                                        [16]
            for a number of specific problems in the oral   denture stomatitis  and confirmed its poten-
            cavity, especially in patients with widespread   tial as a potent preventive and therapeutic

            symptomatic erosions since the direct appli-  agent against oral candidiasis. Due to the
            cation of oral paste, cream or gel preparation   bioadhesive, anti-candida, anti-inflammatory
            is uncomfortable and adheres poorly to the   and wound healing properties of chitosan [27-29] ,
            moist mucous membrane. In patients with     it can be extremely beneficial to maintain
            widespread symptomatic lesions, TA mouth-   the concentration of curcuminoids in an oral

            wash is commonly used for controlling the   cavity and enhance the therapeutic efficacy
            symptoms of the disease. Nevertheless, about   of curcuminoids. Avoiding the use of alcohol
            11.4% of the OLP patients treated with 0.3%   to dissolve curcuminoids in the mouthwash

            or 0.5% TA mouthwash had been found to      formulation is also crucial for a better clinical
                                    [26]
            have fungal superinfection.  It had also been   response and patient compliance. Considering
            reported that 20% of OLP patients treated with   the chronic nature of OLP, risk of oral candidia-
            0.1% TA ointment for 4 weeks had recurrence   sis upon usage of topical corticosteroids, and
            of the disease during the follow up period of   potential therapeutic benefits with the safety

            6 months.  In the present study, an alcohol   profile of CHI-CUR mouthwash; a randomized
                     [6]
            free 0.1% CHI-CUR mouthwash was found       controlled trial with larger number of patients
   35   36   37   38   39   40   41   42   43   44   45