Page 15 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 16 ฉบับที่ 3

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‡´≈≈å¡–‡√Á߇μâ“π¡ MCF7 „πμ”√—∫¬“∫”√ÿß°”≈—ߢÕßÀ¡Õæ◊Èπ∫â“π

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*§≥–·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬å∑“߇≈◊Õ° ¡À“«‘∑¬“≈—¬√“™¿—ØÕÿ∫≈√“™∏“π’ ®—ßÀ«—¥Õÿ∫≈√“™∏“π’ 34000
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“¢“«‘™“«‘∑¬“»“ μ√å·≈–‡∑§‚π‚≈¬’°“√Õ“À“√ §≥–∑√—欓°√∏√√¡™“μ‘ ¡À“«‘∑¬“≈—¬‡∑§‚π‚≈¬’√“™¡ß§≈Õ’ “π «‘∑¬“‡¢μ °≈π§√
®—ßÀ«—¥ °≈π§√ 47160
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§≥–°“√·æ∑¬å·ºπ‰∑¬ ¡À“«‘∑¬“≈—¬ ߢ≈“π§√‘π∑√å «‘∑¬“‡¢μÀ“¥„À≠à ®—ßÀ«—¥ ߢ≈“ 90110
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ºŸâ√—∫º‘¥™Õ∫∫∑§«“¡: pariyapat.bs@gmail.com

∫∑§—¥¬àÕ

°“√«‘®—¬π’ȇªìπ°“√ª√–‡¡‘πμ”√—∫¬“ ®”π«π 15 μ”√—∫ ∑’Ë¡’ √√æ§ÿ≥∫”√ÿß°”≈—ߢÕßÀ¡Õæ◊Èπ∫â“π„π‚√ß
欓∫“≈°“√·æ∑¬å·ºπ‰∑¬ °≈π§√ À≈«ßªŸÉ·øÖ∫ ÿ¿—∑‚∑ ‚¥¬∑”°“√ª√–‡¡‘π‡∫◊ÈÕßμâπ„π√–¥—∫À≈Õ¥∑¥≈Õß∂÷ß
ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–¥â«¬«‘∏’ DPPH radical scavenging assay ·≈– Ferric reducing antioxidant power (FRAP)
À“ª√‘¡“≥ “√øïπÕ≈‘°∑—ÈßÀ¡¥ ª√‘¡“≥ “√ø≈“‚«πÕ¬¥å∑—ÈßÀ¡¥ ª√‘¡“≥ “√·∑ππ‘π ∑¥ Õ∫§«“¡‡ªìπæ‘…μàÕ
‡´≈≈åª°μ‘ (vero cell) ·≈–∑¥ Õ∫§«“¡‡ªìπæ‘…μàÕ‡´≈≈å¡–‡√Á߇μâ“π¡ (MCF7) ¢Õß “√ °—¥®“°‡Õ∑“πÕ≈
º≈°“√»÷°…“ μ”√—∫¬“∑’Ë¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √– Ÿß ÿ¥ ‡¡◊ËÕ∑¥ Õ∫¥â«¬«‘∏’ DPPH §◊Õ μ”√—∫ THS013, THS007 ·≈–
THS006 ¡’§à“‡∑à“°—∫ √âÕ¬≈– 81.6 ± 0.9, 71.7 ± 3.9 ·≈– 69.9 ± 2.0 μ“¡≈”¥—∫ μ”√—∫∑’Ë¡’ƒ∑∏‘Ï„π°“√√’¥‘«´å‡øÕ√å
√‘° Ÿß ÿ¥ §◊Õ THS008, THS015 ·≈– THS013 ¡’§à“‡∑à“°—∫ 3.2 ± 0.0, 3.1 ± 0.1 ·≈– 3.0 ± 0.0 mg of ferrous
sulphate equivalence/g of extract “√ °—¥∑’Ë¡’ª√‘¡“≥øïπÕ≈‘° Ÿß ÿ¥ §◊Õ THS015 æ∫„πª√‘¡“≥ 3.4 mg GAE/
ml “√ °—¥∑’Ë¡’ª√‘¡“≥ø≈“‚«πÕ¬¥å Ÿß ÿ¥ §◊Õ μ”√—∫∑’Ë THS014 æ∫„πª√‘¡“≥ 4.1 mg CE/ml ·≈– “√ °—¥∑’Ë
¡’ª√‘¡“≥·∑ππ‘π Ÿß ÿ¥ §◊Õ μ”√—∫∑’Ë THS003 æ∫„πª√‘¡“≥ 2.3 mg TAE/ml πÕ°®“°π’Èμ”√—∫¬“∑’Ë¡’§«“¡
“¡“√∂„π°“√≈¥§«“¡‡ªìπæ‘…μàÕ‡´≈≈åª°μ‘ ¡“°∑’Ë ÿ¥ §◊Õ THS001 ¡’§à“ IC ‡∑à“°—∫ 18.73 μg/ml ·≈–ƒ∑∏‘Ïμâ“π
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¡–‡√Á߇μâ“π¡¢Õß∑ÿ°μ”√—∫¡’§à“ IC > 50 μg/ml π—Èπ®÷ßπà“®–¡’°“√»÷°…“‚¥¬≈–‡Õ’¬¥∂÷ߪ√– ‘∑∏‘º≈·≈–§«“¡ª≈Õ¥¿—¬
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‡æ◊ËÕæ—≤𓇪ìπº≈‘μ¿—≥±å ÿ¢¿“æμàÕ‰ª

§” ”§—≠: ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–, ƒ∑∏‘Ïμâ“π¡–‡√Áß, ∫”√ÿß°”≈—ß, À¡Õæ◊Èπ∫â“π

Received date 04/10/17 Accepted date 06/11/18

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