Page 30 - journal-7-1-Full

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Table 6 Clinical chemistry values of female rats receiving Thunbergia laurifolia extract for 6 months

Dose of Thunbergia laurifolia extract (mg/kg/day)
Parameters Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
ALP (U/L) 23.80± 7.01 22.33 ± 6.50 25.27 ± 6.74 21.00± 5.45 20.73 ± 5.70 26.07± 5.92
ALT (U/L) 29.47± 9.74 28.40 ±12.60 25.20 ± 8.43 25.53±11.67 19.20 ± 3.40* 23.00± 6.33
AST (U/L) 84.20±24.89 89.33 ±35.70 81.27 ± 15.27 74.20±15.13 70.07 ±11.16 78.20±11.03
Total protein (g/dl) 7.17± 0.26 7.15 ± 0.30 7.07 ± 0.35 7.00± 0.37 7.14 ± 0.43 7.13± 0.28
Albumin (g/dl) 5.16± 0.26 5.20 ± 0.20 5.13 ± 0.25 5.11± 0.16 5.23 ± 0.23 5.05± 0.21
Bilirubin (mg/dl) 0.10± 0.04 0.11 ± 0.04 0.11 ± 0.03 0.13± 0.04 0.15 ± 0.05* 0.12± 0.03
BUN (mg/dl) 24.49± 4.55 24.01 ± 4.12 23.92 ± 3.58 25.49± 4.39 25.69 ± 6.08 24.59± 4.72
Creatinine (mg/dl) 0.86± 0.08 0.89 ± 0.11 0.89 ± 0.11 0.82± 0.09 0.85 ± 0.16 0.89± 0.14
Glucose (mg/dl) 129.75±11.73 123.56 ±14.68 133.35 ± 28.73 124.26±11.51 130.51 ±20.46 131.00±18.95
Uric acid (mg/dl) 1.11± 0.89 1.37 ± 1.18 1.46 ± 1.23 1.09± 1.05 1.29 ± 1.37 1.90± 0.91*
Triglyceride (mg/dl) 82.54±32.47 88.95 ±31.84 74.32 ± 28.39 57.45±20.92 59.95 ±23.10 73.20±26.31
Cholesterol (mg/dl) 70.85±12.93 66.01 ±11.33 63.95 ± 14.15 64.17±16.69 63.97 ± 9.56 67.13±19.08
Sodium (mmol/l) 146.40± 1.12 147.13 ± 1.60 147.47 ± 1.46 147.47± 1.12 147.02 ± 1.03 148.53± 1.36*
Potassium (mmol/l) 4.26± 0.61 4.34 ± 1.25 4.17 ± 1.37 4.05± 0.93 4.13 ± 0.49 4.78± 1.18
Chloride (mmol/l) 110.47± 1.51 111.27 ± 0.96 111.53 ± 1.36 111.60± 1.64 110.73 ± 2.19 112.47± 1.25*

Note : The values are expressed as mean ±± ±± ± SD.
*Significantly different from the control group (p<0.05).

Table 7 Histopathological results of male rats receiving Thunbergia laurifolia extract for 6 months

Dose of Thunbergia laurifolia extract (mg/kg/day)
Organs Microscopic findings Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
Lung Lymphoid proliferated peribronchioles 7/15 10/15 3/15 4/15 6/15 7/15
Heart Focal myocardiosis 3/15 1/15 3/15 0/15 0/15 1/15
Liver Fatty degeneration 6/15 8/15 6/15 7/15 2/15 5/1
Small intestine Gut-associated lymphoid tissue hyperplasia 5/15 1/15 1/15 2/15 4/15 5/15
Large intestine Gut-associated lymphoid tissue hyperplasia 1/15 4/15 1/15 2/15 1/15 2/15
Adrenal gland Cortical fatty degeneration (mild) 0/15 2/15 8/15* 1/15 0/15 0/15
Note : The results are expressed as number of rats with pathological findings / total number of rats examined.
*Significantly different from the control group (p<0.05)

Table 8 Histopathological results of female rats receiving Thunbergia laurifolia extract for 6 months

Dose of Thunbergia laurifolia extract (mg/kg/day)
Organs Microscopic findings Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
Lung Lymphoid proliferated peribronchioles 1/15 2/15 2/15 5/15 3/15 3/15
Heart Focal myocardiosis 0/15 0/15 1/15 0/15 0/15 0/15
Small Intestine Gut-associated lymphoid tissue hyperplasia 1/15 2/15 0/15 2/15 2/15 1/15
Large intestine Gut-associated lymphoid tissue hyperplasia 0/15 0/15 0/15 0/15 1/15 0/15
Note: The results are expressed as number of rats with pathological findings/total number of rats examined.