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Journal of Thai Traditional & Alternative Medicine Vol. 7 No. 1 January-April 2009 ÚÒ

Table 4 Hematological values of female rats receiving Thunbergia laurifolia extract for 6 months

Dose of Thunbergia laurifolia extract (mg/kg/day)
Parameters control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
Hematocrit (%) 45.57± 2.48 45.70± 1.44 46.31± 2.77 46.38± 2.08 46.10 ± 2.78 47.06± 2.10
6 3
RBCs (×10 cells/mm ) 7.87± 0.45 8.02± 0.36 7.97± 0.50 7.88± 0.36 7.78 ± 0.43 8.01± 0.49
Hemoglobin (g/dl) 15.19± 0.75 15.18± 0.42 15.31± 0.79 15.26± 0.61 15.14 ± 0.92 15.58± 0.60
3
MCV (× m /red cell) 57.89± 1.03 56.99± 1.56 58.11± 1.10 58.85± 1.55 59.24 ± 2.00 58.84± 1.77
MCH (pg/red cell) 19.33± 0.75 18.93± 0.53 19.23± 0.48 19.36± 0.39 19.46 ± 0.52 19.48± 0.64
MCHC (g/dl RBCs) 33.37± 0.99 33.22± 0.41 33.09± 0.66 32.91± 0.41 32.86 ± 0.36 33.12± 0.42
3 3
WBCs (×10 cells/mm ) 1.71± 0.41 2.07± 0.45 2.33± 0.69 2.77± 0.54* 2.46 ± 0.84* 2.23± 0.70
Neutrophils (%) 18.76± 6.00 18.58± 5.32 16.00± 3.49 22.17± 8.95 20.57 ±12.82 20.26± 9.52
Eosinophils (%) 1.33± 0.69 1.32± 0.74 1.26± 0.69 1.24± 0.70 0.97 ± 0.43 1.28± 0.69
Lymphocytes (%) 70.45± 8.27 66.93± 9.02 74.35± 5.83 69.18±10.82 70.23 ±13.01 68.18± 13.08
Monocytes (%) 7.10± 3.27 8.27± 5.98 6.47± 5.08 5.31± 2.99 5.95 ± 2.51 8.49± 4.37
Basophils (%) 2.36± 1.00 2.45± 1.34 1.93± 0.93 2.11± 1.18 2.27 ± 0.87 1.77± 0.84
3 3
Platelets (×10 cells/mm ) 921.33±82.02 926.07±73.75 949.51±146.13 916.60±81.77 995.43 ±69.71 941.07±117.86
Note : The values are expressed as mean ±± ±± ± SD.
*Significantly different from the control group (p<0.05).

Table 5 Clinical chemistry values of male rats receiving Thunbergia laurifolia extract for 6 months
Dose of Thunbergia laurifolia extract (mg/kg/day)
Parameters Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
ALP (U/L) 58.13± 8.64 57.40± 8.86 54.00 ±12.76 56.47±10.22 56.27 ± 7.27 53.20± 4.68
ALT (U/L) 33.20± 6.70 41.53±24.65 35.27 ±15.41 26.93± 9.25 24.60 ± 3.60 30.53± 7.94
AST (U/L) 79.73± 9.11 94.93±34.90 85.87 ±21.32 74.87±11.78 8.60 ± 8.17 82.20±10.50
Total protein (g/dl) 6.71± 0.29 6.85± 0.25 6.91 ± 0.46 6.80± 0.34 6.90 ± 0.36 6.89± 0.21
Albumin (g/dl) 4.39± 0.19 4.49± 0.12 4.45 ± 0.11 4.60± 0.13* 4.62 ± 0.17* 4.43± 0.12
Bilirubin (mg/dl) 0.06± 0.03 0.09± 0.03 0.07 ± 0.03 0.08± 0.02 0.10 ± 0.04* 0.7 ± 0.03
BUN (mg/dl) 18.09± 2.23 18.10± 2.65 19.59 ± 2.53 19.25± 1.95 19.54 ± 2.05 18.31± 2.20
Creatinine (mg/dl) 0.75± 0.08 0.73± 0.07 0.78 ± 0.07 0.74± 0.07 0.75 ± 0.06 0.73± 0.05
Glucose (mg/dl) 172.24±29.35 165.33±23.77 181.00 ±37.13 189.43±48.37 185.62 ±37.08 172.43±18.75
Uric acid (mg/dl) 1.99± 1.55 1.91± 1.19 2.37 ± 1.53 2.75± 1.85 3.12 ± 1.81 1.87± 0.89
Triglyceride (mg/dl) 131.90±44.29 108.04±24.87 112.43 ±38.70 103.17±22.27 99.15 ±27.92 135.33±38.04
Cholesterol (mg/dl) 71.63±14.26 64.83±12.52 65.06 ± 9.25 64.86±10.94 71.08 ±20.56 76.59±13.98
Sodium (mmol/l) 145.87± 1.18 147.73± 1.98 147.33 ± 1.88 147.24± 1.83 147.07 ± 1.39 147.73± 1.39
Potassium (mmol/l) 5.23± 0.97 4.85± 1.05 4.95 ± 1.07 5.72± 1.06 6.35 ± 1.22 5.25± 0.80
Chloride (mmol/l) 107.93± 1.71 109.47± 1.85 109.13 ± 1.25 109.60± 1.96 109.27 ± 1.67 109.87± 1.68*
Note : The values are expressed as mean ±± ±± ± SD.
*Significantly different from the control group (p<0.05).

Effects on relative weight of organs control group (Table 1). Female rats receiving TLE at
Male rats receiving TLE at the dose of 2,000 the highest dose had a significant increase in rela-
mg/kg/day showed significant increases in relative tive kidney weight compared with the controls
spleen and kidney weights when compared with the (Table 2).