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Table 2 Body weight (g) and percentage relative organ weight of female rats receiving Thunbergia laurifolia extract for 6 months

Dose of Thunbergia laurifolia extract (mg/kg /day)
Parameters Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15

Initial body weight 175.13 ± 8.41 175.31 ± 5.30 173.66 ± 9.83 175.51 ± 7.86 178.39 ±11.80 172.41 ± 9.95
Final body weight 313.39 ±26.00 327.75 ±30.93 315.03 ±24.96 33.85 ±29.48 32.25 ±35.92 311.44 ±34.77
Brain 0.65 ± 0.05 0.63 ± 0.07 0.65 ± 0.06 0.65 ± 0.05 0.63 ± 0.07 0.64 ± 0.06
Heart 0.30 ± 0.03 0.29 ± 0.03 0.29 ± 0.03 0.28 ± 0.02 0.29 ± 0.03 0.28 ± 0.02
Lung 0.40 ± 0.03 0.41 ± 0.06 0.41 ± 0.04 0.40 ± 0.04 0.41 ± 0.04 0.42 ± 0.05
Liver 2.32 ± 0.14 2.28 ± 0.20 2.33 ± 0.17 2.35 ± 0.17 2.49 ± 0.16 2.46 ± 0.19
Stomach 0.53 ± 0.07 0.49 ± 0.07 0.50 ± 0.05 0.51 ± 0.06 0.53 ± 0.07 0.52 ± 0.07
Spleen 0.21 ± 0.02 0.21 ± 0.04 0.21 ± 0.04 0.22 ± 0.02 0.24 ± 0.03 0.21 ± 0.02
Right kidney 0.25 ± 0.02 0.25 ± 0.02 0.25 ± 0.02 0.27 ± 0.02 0.27 ± 0.03* 0.27 ± 0.02
Left kidney 0.24 ± 0.02 0.23 ± 0.03 0.24 ± 0.02 0.25 ± 0.02 0.27 ± 0.03* 0.25 ± 0.02
Right adrenal 0.012 ± 0.001 0.012 ± 0.003 0.013± 0.002 0.013± 0.003 0.011 ± 0.002 0.012 ± 0.003
Left adrenal 0.013 ± 0.003 0.013 ± 0.002 0.014± 0.003 0.014± 0.002 0.013 ± 0.002 0.014 ± 0.003
Bladder 0.031 ± 0.013 0.028 ± 0.007 0.032± 0.011 0.030± 0.003 0.029 ± 0.006 0.028 ± 0.006
Uterus 0.280 ± 0.127 0.232 ± 0.060 0.256± 0.061 0.234± 0.056 0.207 ± 0.044 0.237 ± 0.068
Note : The values are expressed as mean ±± ±± ± SD.
*Significantly different from the control group (p<0.05).

Table 3 Hematological values of male rats receiving Thunbergia laurifolia extract for 6 months
Dose of Thunbergia laurifolia extract (mg/kg/day)
Parameters Control 20 200 1000 2000 2000R
N = 15 N = 15 N = 15 N = 15 N = 15 N = 15
Hematocrit (%) 47.25± 2.10 47.03 ± 1.24 46.91± 2.99 47.30± 2.58 47.42 ± 3.05 46.11± 1.23
6
3
RBCs (×10 cells/mm ) 9.01± 0.43 9.02 ± 0.44 8.93± 0.70 8.62± 0.40 8.35 ± 0.53* 8.25± 0.22*
Hemoglobin (g/dl) 15.50± 0.63 15.47 ± 0.42 15.34± 0.87 15.42± 0.76 15.38 ± 0.87 15.09± 0.41
3
MCV (×m /red cell) 52.50± 2.18 52.23 ± 2.33 52.61± 2.17 54.86± 1.91* 56.84 ± 1.69* 55.87± 1.39*
MCH (pg/red cell) 17.23± 0.80 17.20 ± 0.81 17.23± 0.73 17.88± 0.56 18.43 ± 0.57* 18.28± 0.54*
MCHC (g/dl RBC) 32.81± 0.43 32.93 ± 0.31 32.73± 0.47 32.61± 0.31 32.44 ± 0.48 32.73± 0.61
3 3
WBCs (×10 cells/mm ) 3.79± 0.58 2.80 ± 1.10 2.83± 0.87 3.10± 0.71 3.54 ± 1.30 3.71± 1.08
Neutrophils (%) 16.23± 6.94 24.49 ± 9.24 23.87± 5.82 21.56± 9.02 15.99 ± 5.03 20.42±10.17
Eosinophils (%) 1.87± 0.81 1.74 ± 0.48 1.35± 0.38 1.58± 0.65 1.25 ± 0.35 1.44± 0.39
Lymphocytes (%) 71.52±10.16 61.33 ±11.29 60.71± 9.09 64.45± 10.56 70.63 ± 9.45 67.76±12.10
Monocytes (%) 7.39± 2.11 8.79 ± 2.50 10.59± 4.20 9.14± 3.94 8.67 ± 4.29 7.47± 2.39
Basophils (%) 3.00± 1.48 3.65 ± 2.01 3.47± 1.59 3.27± 1.38 3.47 ± 1.39 2.90± 0.73
3
3
Platelets (×10 cells/mm )968.93±115.41 930.14 ±180.80 956.20±137.80 981.37±100.96 976.83 ±159.26 956.67±65.15
Note : The values are expressed as mean ±± ±± ± SD.
*Significantly different from the control group (p<0.05).

tion of male and female rats receiving TLE at any group of rats receiving TLE as well as in the control
dose were not significantly different from those of group. TLE-treated rats did not show any toxic signs
their corresponding control groups throughout the six- and mortality throughout the experiment. Initial and
month period (data not shown). There was no abnor- final body weights of each group are expressed in
mality in physical appearance and behavior in any Tables 1 and 2.