Page 75 - Acrobat J Trad-21-3-2566

558 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 3 กันยายน-ธันวาคม 2566

The Study on Effectiveness of Gel Patches Containing Yapoktongnoikublohit
Extract on Pain Relief in Primary Dysmenorrhea

Narita Suphon , Noor-asikeen Samae , Nurihan Che-hah , Pirunrat Sae-Lim ,
*
†
*
*
Sukanjana Kamlungmak †,‡
* Bachelor of Thai Traditional Medicine, Faculty of health and sports sciences, Thaksin University,
Ban Phrao Sub-District, Pa Phayom District, Phatthalung 93110, Thailand
† Thai Traditional medicine program, Faculty of health and sports sciences, Thaksin University,
Ban Phrao Sub-District, Pa Phayom District, Phatthalung 93110, Thailand
Corresponding author: ksukanjana@tsu.ac.th
‡
Abstract

Introduction and Objectives: Yapoktongnoikublohit (YTK) recipe is in a traditional Thai medicine text
used for pain relief in primary dysmenorrhea. Therefore, it is suitable for use as an essential ingredient in a gel
patch formula to reduce painful periods. This study aimed (1) to determine the physical stability, (2) to evaluate
skin irritation, (3) to test the efficacy, and (4) to evaluate users’ satisfaction with YTK-containing gel patch for
pain relief in primary dysmenorrhea.
Methods: The gel patch was prepared using Cissampelos pareira (khruea ma noi in Thai) extract, YTK
extract, and gelatin. We used a patch test for skin irritation evaluation in 30 participants. The cross-over study was
used to evaluate the efficacy of the gel patch with three treatments: YTK poultice, gel patch, and YTK gel patch.
Menstrual pain levels were assessed using the visual analogue scale (VAS) at 30 minutes, 1 hour, and 4 hours after
treatment.
Results: The best formula contained 69.56% w/w C. pareira extract, 17.40% w/w YTK extract, and 13.04%
w/w gelatin. The skin test did not show any skin irritation. The YTK patch could relief menstrual pain significantly
(p-value ≤ 0.05) compared with other treatments. And the users’ satisfaction level with the YTK patch was high.
Discussion: Previous studies have shown that the ingredients of the YTK formula were found to inhibit
the process of prostaglandin synthesis, inhibit the enzyme cyclooxygenase-1 and cyclooxygenase-2, and reduce
inflammation.
Conclusion and Recommendation: The YTK gel patch can be developed in the form that is convenient
for use and can be carried easily. Moreover, it can also be further used by small-sized enterprises in preparing or
producing other products.

Key words: dysmenorrhea, Yapoktongnoikublohit (YTK) formula, Cissampelos pareira, microwave-assisted
extraction