Page 18 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 10 ฉบับที่ 3

168 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë 10 ©∫—∫∑’Ë 3°—𬓬π-∏—𫓧¡ 2555

§«“¡¢—¥·¬âߢÕߺ≈μàÕ°“√ √â“ß PBP ¢Õß MRSA ‰«¢Õß penicillins-resistant S. aureus μàÕ¬“
36
°≈à“«§◊Õ Yam ·≈–§≥– (1997) æ∫«à“ “√ °—¥ ceftazidime ·≈– methicillin ‰¥â‡™àπ‡¥’¬«
27
®“°™“ “¡“√∂≈¥ª√‘¡“≥°“√º≈‘μ¢Õß PBP1 ·≈– °—π ·¡â«à“°“√¥◊ÈÕ¬“¥â«¬°≈‰°°“√‡ª≈’ˬπ·ª≈߇ªÑ“
PBP2a ¢Õß·∫§∑’‡√’¬™π‘¥π’È ·μà¢≥–‡¥’¬«°—π∫“ß À¡“¬¢Õ߬“π—Èπ®–æ∫„π·∫§∑’‡√’¬À≈“¬™π‘¥ ·μà

√“¬ß“π°“√«‘®—¬∫àß™’È«à“ “√ ”§—≠®“°™“´÷ËßÕÕ°ƒ∑∏‘Ï æ∫«à“¡’‡æ’¬ß√“¬ß“π°“√∑¥ Õ∫ “√≈¥°“√¥◊ÈÕ¬“„π
≈¥°“√¥◊ÈÕμàÕ¬“ oxacillin π—Èπ ‰¡à¡’º≈μàÕ°“√ S. aureus ‡∑à“π—Èπ √«¡∑—Èß¡’°“√»÷°…“„πæ◊™‰¡à°’Ë™π‘¥
37,38
· ¥ßÕÕ°À√◊Õª√‘¡“≥¢Õß PBP2a ·μà°≈‰°°“√ °“√»÷°…“„πæ◊™∑’Ë¡’§«“¡À≈“°À≈“¬¡“°¢÷Èπ Õ“® àß
ÕÕ°ƒ∑∏‘Ï∑’Ë ”§—≠§◊Õ°“√·∑√°μ—«¢Õß “√¥—ß°≈à“« º≈„Àâæ∫ “√≈¥°“√¥◊ÈÕ¬“∑’Ë¡’ª√– ‘∑∏‘º≈ “¡“√∂π”

‡¢â“‰ª„πºπ—߇´≈≈å¢Õß·∫§∑’‡√’¬π’È “√°≈ÿà¡ polyphe- ¬“°≈ÿà¡ beta-lactam °≈—∫¡“„™â√—°…“‚√§´÷Ë߇°‘¥
nols π’Ȭ—ß·¬°‰¥â®“° Caesalpinia spinosa (Tara) ®“°·∫§∑’‡√’¬¥◊ÈÕ¬“‰¥â¥’Õ’°§√—Èß

·≈–æ∫«à“¡’§«“¡ “¡“√∂„π°“√≈¥°“√¥◊ÈÕ¬“ oxacil-
“√≈¥°“√¥◊ÈÕ¬“∑’ËÕÕ°ƒ∑∏‘Ï‚¥¬°“√‡æ‘Ë¡°“√
lin ·≈– cephapirin ¢Õß S. aureus ∑—Èß°≈ÿà¡∑’Ë¥◊ÈÕ¬“
40 – ¡¢Õ߬“¿“¬„π‡´≈≈å
·≈–°≈ÿà¡∑’ˉ«μàÕ¬“™π‘¥π’È “√°≈ÿà¡ flavonoids
‡™àπ galangin ´÷Ëß√∫°«π°“√∑”ß“π¢Õߺπ—߇´≈≈å °“√∑’ˬ“ªØ‘™’«π–®–ÕÕ°ƒ∑∏‘ω¥â μ—«¬“®–
40
·≈–‡¬◊ËÕÀÿ⡇´≈≈å¢Õß S. aureus “¡“√∂‡æ‘Ë¡§«“¡ μâÕߺà“π‡¢â“‡´≈≈å¢Õß·∫§∑’‡√’¬‡ ’¬°àÕπ °“√‡¢â“ Ÿà

μ“√“ß∑’Ë 2 μ—«Õ¬à“ß “√≈¥°“√¥◊ÈÕ¬“®“° ¡ÿπ‰æ√´÷ËßÕÕ°ƒ∑∏‘Ï‚¥¬°“√¬—∫¬—Èß°“√‡ª≈’ˬπ·ª≈ßμ”·Àπà߇ªÑ“À¡“¬¢Õ߬“

Medicinal plants Active constituents/Active extracts Antibiotics Pathogens
Alpinia officinarum Galangin (√Ÿª∑’Ë 2°) ceftazidime penicillins-resistant
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methicillin Staphylococcus aureus
Berberidaceae Flavone, 6,7-DF6,7-DF, 3',4'-DF7,8-DF, methicillin methicillin resistant
and Senna Luteolin, Kaempferol, Apigenin S. aureus (MRSA)
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petersiana (√Ÿª∑’Ë 2®) methicillin susceptible
S. aureus (MSSA)

Caesalpinia Ethyl gallate (3), Propyl gallate (4), cephapirin MRSA/MSSA
spinosa Isobutyl gallate (5) Butyl gallate (6) oxacillin
isoAmyl gallate (7), Pentyl gallate (8)
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(√Ÿª∑’Ë 2©)
Camellia sinensis Epicatechin gallate (ECg) ·≈– epigallocatechin oxacillin mecA-containing strains
gallate (EGCg) (√Ÿª∑’Ë 2™ ), epicatechin (EC) of S. aureus
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·≈– epigallocatechin (EGC) (√Ÿª∑’Ë 2´)
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EGC carbapenem MRSA
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ECg oxacillin MRSA