Page 42 - วารสารปีที่16ฉบับที่2

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√Ÿª∑’Ë 4 Ÿμ√‚§√ß √â“ß∑“ß‡§¡’¢Õß “√°≈ÿà¡ rhinacanthins

°“√∑¥ Õ∫ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“°≈ÿà¡‡¥Õ√å¡“‚μ- „∫ ≈”μâπ ·≈–√“°æ∫«à“ “√ °—¥®“° à«π√“°¡’ƒ∑∏‘Ï
‰øμå¢Õß “√°≈ÿà¡ rhinacanthins ·≈–‡ª√’¬∫‡∑’¬∫ ¥’∑’Ë ÿ¥‡¡◊ËÕ‡ª√’¬∫‡∑’¬∫°—∫ à«πÕ◊Ëπ¢Õßæ◊™ ‚¥¬· ¥ß

§«“¡·√ß„π°“√· ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“μàÕ‡™◊ÈÕ∑’Ë„™â ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“μàÕ‡™◊ÈÕ°≈ÿà¡‡¥Õ√å¡“‚μ‰øμå∑—Èß 3 ™π‘¥
∑¥ Õ∫∑—Èß 3 ™π‘¥ ®“°§à“ MICs æ∫«à“ 3 ¡’ƒ∑∏‘Ï ∑’Ë„™â∑¥ Õ∫∑’Ë MICs πâÕ¬°«à“ 6.25 ‰¡‚§√°√—¡μàÕ
μâ“π‡™◊ÈÕ√“¥’°«à“ 2, 4 ·≈– 1 ‚¥¬§«“¡·√ß„π°“√ ¡‘≈≈‘≈‘μ√ „π¢≥–∑’Ë “√ °—¥®“° à«π„∫· ¥ßƒ∑∏‘Ï

μâ“π‡™◊ÈÕ√“¢Õß 3 > 1 > 4 > 2 μ“¡≈”¥—∫ (μ“√“ß∑’Ë 1) μâ“π‡™◊ÈÕ√“μàÕ‡™◊ÈÕ°≈ÿà¡‡¥Õ√å¡“‚μ‰øμå∑—Èß 3 ™π‘¥∑’Ë
MICs √–À«à“ß 12.5-50 ‰¡‚§√°√—¡μàÕ¡‘≈≈‘≈‘μ√
Õ¿‘ª√“¬º≈
·≈– “√ °—¥®“° à«π≈”μâπ‰¡à· ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“
°“√»÷°…“ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“°≈ÿà¡‡¥Õ√å¡“‚μ‰øμå μàÕ‡™◊ÈÕ°≈ÿà¡‡¥Õ√å¡“‚μ‰øμå∑’Ë§«“¡‡¢â¡¢âπ∑’Ë∑”°“√
¢Õß “√ °—¥∑Õßæ—π™—Ëß ‰¥â‡≈◊Õ°‡™◊ÈÕ√“∑’Ë‡ªìπ “‡Àμÿ ∑¥ Õ∫ ´÷Ëßº≈°“√∑¥ Õ∫π’È Õ¥§≈âÕß°—∫ √√æ§ÿ≥

¢Õß‚√§º‘«Àπ—ß°≈ÿà¡‡¥Õ√å¡“‚μ‰øμå 3 ™π‘¥ §◊Õ T. ∑’Ë√–∫ÿμ“¡°“√·æ∑¬å·ºπ‚∫√“≥¢Õß‰∑¬„π°“√„™â
[6]
rubrum ‡™◊ÈÕ√“„π°≈ÿà¡ Anthropophilic species à«π¢Õß„∫·≈–√“°∑Õßæ—π™—Ëß ”À√—∫·°â°≈“°

(‡™◊ÈÕ√“°≈ÿà¡∑’Ë¡—°°àÕ‚√§„π§π), T. mentagrophytes πÕ°®“°π’È “√ °—¥®“°„∫∑Õßæ—π™—Ëß ¬—ß¡’√“¬ß“π
‡™◊ÈÕ√“„π°≈ÿà¡ Zoophilic species (‡™◊ÈÕ√“°≈ÿà¡∑’Ë¡—° ƒ∑∏‘Ïμâ“π‡™◊ÈÕ·∫§∑’‡√’¬·°√¡∫«°∑’Ë°àÕ‚√§„π¡πÿ…¬å
°àÕæ¬“∏‘ ¿“æ„π —μ«å) ·≈– M. gypseum ‡™◊ÈÕ√“ ¥â«¬ ‚¥¬¡’§«“¡®”‡æ“–μàÕ‡™◊ÈÕ Bacilli ¡“°°«à“

„π°≈ÿà¡ Geophilic species (‡™◊ÈÕ√“°≈ÿà¡∑’Ë‡®√‘≠‰¥â Cocci ·μà‰¡à· ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ·∫§∑’‡√’¬·°√¡≈∫
¥’„π¥‘π æ◊™ ·≈– ‘Ëß·«¥≈âÕ¡) ´÷Ëß‡™◊ÈÕ∑—Èß “¡™π‘¥π’È ‡™àπ Escherichia coli, Pseudomonas aeruginosa,
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‡ªìπ‡™◊ÈÕ°àÕ‚√§∑’Ëæ∫∫àÕ¬„πª√–‡∑»¿Ÿ¡‘¿“§‡Õ‡™’¬ ·≈– Enterobacter spp. ·≈– Klebsiella spp. ·≈–
T. rubrum ‡ªìπ‡™◊ÈÕ°àÕ‚√§∑’Ë¡—°æ∫∫àÕ¬„π‚√§°≈“° “√ °—¥„∫∑Õßæ—π™—Ëß¡’√“¬ß“πƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“
[20]
∑’Ë≈”μ—« °“√∑¥ Õ∫ƒ∑∏‘Ï¢Õß “√ °—¥æ◊™·Àâß à«π Malassezia furfur ·≈– Malassezia globosa ´÷Ëß

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