Page 74 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 14 ฉบับที่ 3
P. 74

292






























             √Ÿª∑’Ë 2 time-kill curves ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“·≈–‰æ≈¥”μàÕ‡™◊ÈÕ C. albicans ‡ª√’¬∫‡∑’¬∫°—∫ ketoconazole ‚¥¬
                    —≠≈—°…≥å ♦ ·∑π control, ■ ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“∑’Ë MIC (25 μg/mL), ■■ ·∑𧫓¡
                   ‡¢â¡¢âπ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“∑’Ë MFC (100 μg/mL), ● ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥‰æ≈¥”∑’Ë MIC (50
                   μg/mL),  ●● ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥‰æ≈¥”∑’Ë MFC (100 μg/mL), ·≈–  ▲ ·∑𧫓¡‡¢â¡¢âπ¢Õß
                   ketoconazole ∑’Ë MIC (100 μg/mL)


             §—¥‡≈◊Õ°‡Àßâ“¢Õß ¡ÿπ‰æ√„π«ß»åπ’È∑’Ë¡’„™â·≈–  ·≈–«à“ππ“ߧ” · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“∑’Ë MICs ·≈–

             ®”Àπà“¬∑—Ë«‰ª¡“∑¥ Õ∫ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“∑’ˇªì𠓇Àμÿ  MFCs 3.13 - 100 ‰¡‚§√°√—¡μàÕ¡‘≈≈‘≈‘μ√ ·μà‰¡à
             „π°“√°àÕ‚√§∑’˺‘«Àπ—ß ‚¥¬„™â‡™◊ÈÕ¬’ μå C. albicans  · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“μàÕ C. albicans ∑’˧«“¡‡¢â¡¢âπ

             ·≈–‡™◊ÈÕ√“·∫∫¡’‡ âπ„¬°≈ÿࡇ¥Õ√å¡“‚μ‰øμå 3 ™π‘¥ §◊Õ  μË”°«à“ 100 ‰¡‚§√°√—¡μàÕ¡‘≈≈‘≈‘μ√ ¬°‡«âπ¢¡‘Èπ¢“«
             T. rubrum ‡ªìπμ—«·∑π¢Õß°≈ÿࡇ™◊ÈÕ√“∑’Ë¡—°°àÕ‚√§„π  ªÉ“ · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ C. albicans ∑’Ë MIC 25 ‰¡‚§√
             §π (anthropophilic species),  T. menta-    °√—¡μàÕ¡‘≈≈‘≈‘μ√ ·≈–¶à“‡™◊ÈÕ√“∑’Ë MFC 100 ‰¡‚§√

             grophytes ‡ªìπμ—«·∑π¢Õß°≈ÿࡇ™◊ÈÕ√“∑’Ë¡—°°àÕ‚√§„π  °√—¡μàÕ¡‘≈≈‘≈‘μ√ Õ¬à“߉√°Áμ“¡®“°æ◊™ °ÿ≈¢¡‘Èπ 7
              —μ«å (zoophilic species), ·≈– M. gypseum ‡ªìπ  ™π‘¥∑’Ëπ”¡“∑¥ Õ∫æ∫«à“¢¡‘Èπ¢“«‰¡à· ¥ßƒ∑∏‘Ïμâ“π
             μ—«·∑π¢Õ߇™◊ÈÕ√“∑’ˇ®√‘≠‰¥â¥’„π ‘Ëß·«¥≈âÕ¡ (geo-  ‡™◊ÈÕ√“∑’Ë„™â∑¥ Õ∫∑’˧«“¡‡¢â¡¢âπμË”°«à“ 100 ‰¡‚§√

             philic species) ·≈–°àÕ‚√§‚¥¬°“√μ‘¥‡™◊ÈÕ∑’Ë√Õ¬  °√—¡μàÕ¡‘≈≈‘≈‘μ√ πÕ°®“°π’Ⱥ≈°“√∑¥ Õ∫æ◊™ °ÿ≈
             ∂≈Õ°À√◊Õ∫“¥·º≈∫πº‘«Àπ—ß ´÷Ë߇™◊ÈÕ‡À≈à“π’ȇªìπ‡™◊ÈÕ  Õ◊Ëπ∑’Ë∑”°“√»÷°…“ ‡™àπ  °ÿ≈¢‘ß (Zingiber),  °ÿ≈‡ª√“–
                                          [1]
             °àÕ‚√§∑’Ëæ∫∫àÕ¬„πª√–‡∑»‡¢μ√âÕπ™◊Èπ         (Kaempferia),  °ÿ≈°√–™“¬ (Boesenbergia), ·≈–
                 °“√»÷°…“π’Èæ∫«à“‡Àßâ“¢Õß ¡ÿπ‰æ√ à«π„À≠à   °ÿ≈¢à“ (Alpenia) æ∫«à“„πæ◊™ °ÿ≈¢‘ß∑’Ë∑”°“√»÷°…“
             · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“°≈ÿࡇ¥Õ√å¡“‚μ‰øμå∑’Ë∑”°“√»÷°…“  4 ™π‘¥ (°√–∑◊Õ ¢‘ß ‰æ≈ ·≈–‰æ≈¥”)  “√ °—¥®“°

             ‚¥¬‡©æ“–Õ¬à“߬‘Ëßæ◊™ °ÿ≈¢¡‘Èπ (Curcuma) ‰¥â·°à  ‡ÀßⓉæ≈¥”· ¥ßƒ∑∏‘Ï¥’∑’Ë ÿ¥‡¡◊ËÕ‡∑’¬∫°—∫æ◊™ °ÿ≈
             ¢¡‘Èπ¢“«ªÉ“ ¢¡‘Èπ™—π ¢¡‘Èπ¥” ¢¡‘ÈπÕâÕ¬ «à“π™—°¡¥≈Ÿ°  ‡¥’¬«°—π ·≈–¡’§«“¡·√ߢÕ߃∑∏‘Ïμâ“π‡™◊ÈÕ√“„°≈â
   69   70   71   72   73   74   75   76   77   78   79