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√Ÿª∑’Ë 2 time-kill curves ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“·≈–‰æ≈¥”μàÕ‡™◊ÈÕ C. albicans ‡ª√’¬∫‡∑’¬∫°—∫ ketoconazole ‚¥¬
—≠≈—°…≥å ♦ ·∑π control, ■ ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“∑’Ë MIC (25 μg/mL), ■■ ·∑𧫓¡
‡¢â¡¢âπ¢Õß “√ °—¥¢¡‘Èπ¢“«ªÉ“∑’Ë MFC (100 μg/mL), ● ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥‰æ≈¥”∑’Ë MIC (50
μg/mL), ●● ·∑𧫓¡‡¢â¡¢âπ¢Õß “√ °—¥‰æ≈¥”∑’Ë MFC (100 μg/mL), ·≈– ▲ ·∑𧫓¡‡¢â¡¢âπ¢Õß
ketoconazole ∑’Ë MIC (100 μg/mL)
§—¥‡≈◊Õ°‡Àßâ“¢Õß ¡ÿπ‰æ√„π«ß»åπ’È∑’Ë¡’„™â·≈– ·≈–«à“ππ“ߧ” · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“∑’Ë MICs ·≈–
®”Àπà“¬∑—Ë«‰ª¡“∑¥ Õ∫ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“∑’ˇªì𠓇Àμÿ MFCs 3.13 - 100 ‰¡‚§√°√—¡μàÕ¡‘≈≈‘≈‘μ√ ·μà‰¡à
„π°“√°àÕ‚√§∑’˺‘«Àπ—ß ‚¥¬„™â‡™◊ÈÕ¬’ μå C. albicans · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“μàÕ C. albicans ∑’˧«“¡‡¢â¡¢âπ
·≈–‡™◊ÈÕ√“·∫∫¡’‡ âπ„¬°≈ÿࡇ¥Õ√å¡“‚μ‰øμå 3 ™π‘¥ §◊Õ μË”°«à“ 100 ‰¡‚§√°√—¡μàÕ¡‘≈≈‘≈‘μ√ ¬°‡«âπ¢¡‘Èπ¢“«
T. rubrum ‡ªìπμ—«·∑π¢Õß°≈ÿࡇ™◊ÈÕ√“∑’Ë¡—°°àÕ‚√§„π ªÉ“ · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ C. albicans ∑’Ë MIC 25 ‰¡‚§√
§π (anthropophilic species), T. menta- °√—¡μàÕ¡‘≈≈‘≈‘μ√ ·≈–¶à“‡™◊ÈÕ√“∑’Ë MFC 100 ‰¡‚§√
grophytes ‡ªìπμ—«·∑π¢Õß°≈ÿࡇ™◊ÈÕ√“∑’Ë¡—°°àÕ‚√§„π °√—¡μàÕ¡‘≈≈‘≈‘μ√ Õ¬à“߉√°Áμ“¡®“°æ◊™ °ÿ≈¢¡‘Èπ 7
—μ«å (zoophilic species), ·≈– M. gypseum ‡ªìπ ™π‘¥∑’Ëπ”¡“∑¥ Õ∫æ∫«à“¢¡‘Èπ¢“«‰¡à· ¥ßƒ∑∏‘Ïμâ“π
μ—«·∑π¢Õ߇™◊ÈÕ√“∑’ˇ®√‘≠‰¥â¥’„π ‘Ëß·«¥≈âÕ¡ (geo- ‡™◊ÈÕ√“∑’Ë„™â∑¥ Õ∫∑’˧«“¡‡¢â¡¢âπμË”°«à“ 100 ‰¡‚§√
philic species) ·≈–°àÕ‚√§‚¥¬°“√μ‘¥‡™◊ÈÕ∑’Ë√Õ¬ °√—¡μàÕ¡‘≈≈‘≈‘μ√ πÕ°®“°π’Ⱥ≈°“√∑¥ Õ∫æ◊™ °ÿ≈
∂≈Õ°À√◊Õ∫“¥·º≈∫πº‘«Àπ—ß ´÷Ë߇™◊ÈÕ‡À≈à“π’ȇªìπ‡™◊ÈÕ Õ◊Ëπ∑’Ë∑”°“√»÷°…“ ‡™àπ °ÿ≈¢‘ß (Zingiber), °ÿ≈‡ª√“–
[1]
°àÕ‚√§∑’Ëæ∫∫àÕ¬„πª√–‡∑»‡¢μ√âÕπ™◊Èπ (Kaempferia), °ÿ≈°√–™“¬ (Boesenbergia), ·≈–
°“√»÷°…“π’Èæ∫«à“‡Àßâ“¢Õß ¡ÿπ‰æ√ à«π„À≠à °ÿ≈¢à“ (Alpenia) æ∫«à“„πæ◊™ °ÿ≈¢‘ß∑’Ë∑”°“√»÷°…“
· ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“°≈ÿࡇ¥Õ√å¡“‚μ‰øμå∑’Ë∑”°“√»÷°…“ 4 ™π‘¥ (°√–∑◊Õ ¢‘ß ‰æ≈ ·≈–‰æ≈¥”) “√ °—¥®“°
‚¥¬‡©æ“–Õ¬à“߬‘Ëßæ◊™ °ÿ≈¢¡‘Èπ (Curcuma) ‰¥â·°à ‡ÀßⓉæ≈¥”· ¥ßƒ∑∏‘Ï¥’∑’Ë ÿ¥‡¡◊ËÕ‡∑’¬∫°—∫æ◊™ °ÿ≈
¢¡‘Èπ¢“«ªÉ“ ¢¡‘Èπ™—π ¢¡‘Èπ¥” ¢¡‘ÈπÕâÕ¬ «à“π™—°¡¥≈Ÿ° ‡¥’¬«°—π ·≈–¡’§«“¡·√ߢÕ߃∑∏‘Ïμâ“π‡™◊ÈÕ√“„°≈â