Page 13 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 1

Journal of Thai Traditional & Alternative Medicine Vol. 11 No. 1 January-April 2013 7

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π“∑’ ´÷ËßπâÕ¬°«à“°≈ÿࡧ«∫§ÿ¡ „π¢≥–∑’Ëæƒμ‘°√√¡ (IC =10.64 ± 2.09 ‰¡‚§√‚¡≈“√å)
50
∑“߇滥â“πÕ◊ËπÊ ‰¡à·μ°μà“ß°—π (frequency, in- 1.5 º≈μàÕ√–∫∫ ◊∫æ—π∏ÿå‡æ»™“¬°“√ ÿà¡
tromission frequency, mount latency À√◊Õ in- ∑¥≈Õß„πÀπŸ·√μ‡æ»ºŸâ ·∫à߇ªìπ 2 °≈ÿࡧ◊Õ°≈ÿà¡
tromission latency) ·≈–®“°°“√»÷°…“§«“¡‡ªì𠧫∫§ÿ¡·≈–°≈ÿà¡∑’Ë„Àâ°√–™“¬¥” 1,000 ¡°./°°./«—π

æ‘…æ∫«à“ ‰¡à¡’§«“¡·μ°μà“ߢÕߌ’‚¡‚°≈∫‘π, ‡¡Á¥ ‚¥¬„Àâ∑“ߪ“° ‡ªìπ‡«≈“ 45 «—π æ∫«à“°√–™“¬¥”
‡≈◊Õ¥¢“« ·≈–‰¡à¡’º≈μàÕ‰μ, μ—∫, §à“ blood urea ∑”„ÀâπÈ”Àπ—°μ—«‡æ‘Ë¡¢÷Èπ‡¡◊ËÕ‡ª√’¬∫‡∑’¬∫°—∫°≈ÿà¡
nitrogen, creatinine, aspartate aminotrans- §«∫§ÿ¡ ·μà‰¡à¡’§«“¡·μ°μà“ߢÕßπÈ”Àπ—°¢Õß

ferase ·≈– alanine aminotransferase ·μஓ° Õ«—¬«– ◊∫æ—π∏ÿå (Õ—≥±–, seminal vesicle plus
°“√»÷°…“∑“ß®ÿ≈欓∏‘«‘∑¬“æ∫«à“ ¡’°“√‡ª≈’ˬπ·ª≈ß coagulating gland, levator ani muscle plus

∑“ß —≥∞“π«‘∑¬“„πμ—∫ √ÿª‰¥â«à“ “√ °—¥°√–™“¬ bulbocarvernosus muscle ·≈– glans penis,
¥”∑’Ë 240 ¡°./°°. ≈¥‡«≈“„π°“√®—∫§Ÿà¢ÕßÀπŸ„π 10 ¬°‡«âπμàÕ¡≈Ÿ°À¡“°), ‰μ, μàÕ¡À¡«°‰μ, gastrac-
π“∑’·√° ·≈–‰¡à‡À¡“– ¡‡¡◊ËÕ„™â°—∫§π„πª√‘¡“≥ Ÿß nemius muscle, √–¥—∫ follicle stimulating hor-
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·≈–μ‘¥μàÕ°—π‡ªìπ‡«≈“π“π mone, luteinizing hormone ·≈–æƒμ‘°√√¡
1.3 ƒ∑∏‘ϧ≈“¬°“√°≈â“¡‡π◊ÈÕ cavernosum °“√®—∫§Ÿà ·μà√–¥—∫¢Õß testosterone ·≈– pro-

∑’Ë penis ®“°°“√»÷°…“„π isolated human gesterone ≈¥≈߇¡◊ËÕ„Àâ°√–™“¬¥” 30 «—π √–¥—∫ cor-
cavernosum æ∫«à“ “√ 3, 5, 7, 3', 4'-penta- ticosterone ≈¥≈ß„π 20 «—π·≈– 30 «—π √ÿª
methoxyflavone „π‡Àßâ“°√–™“¬¥” ¡’°≈‰°°“√ ‰¥â«à“°√–™“¬¥”‰¡à¡’º≈√∫°«πμàÕ hypothalamic-

ÕÕ°ƒ∑∏‘ϧ≈“¬°“√°≈â“¡‡π◊ÈÕ cavernosum ·μ° pituitary-testicular axis À√◊Õ√–∫∫ ◊∫æ—π∏ÿå‡æ»
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μà“ß®“° sildenafil ´÷Ë߇ªìπ phosphodiesterase ™“¬
inhibitor ‚¥¬ÕÕ°ƒ∑∏‘Ϻà“π voltage-dependent °“√ ÿà¡∑¥≈Õß„πÀπŸ·√μ‰¡à‡μÁ¡«—¬∑’Ë∂Ÿ° cas-

2+
Ca channels ·≈–°≈‰°Õ◊Ëπ∑’ˇ°’ˬ«¢âÕß°—∫ calcium trated ‚¥¬·∫à߇ªìπ 2 °≈ÿࡧ◊Õ°≈ÿࡧ«∫§ÿ¡·≈–
mobilization ¡’ƒ∑∏‘ÏÕàÕπ„π°“√∑”„À⇰‘¥°“√À≈—Ëß °≈ÿà¡∑’Ë„Àâ°√–™“¬¥” 1,000 ¡°./°°. ‚¥¬„Àâ∑“ߪ“°
nitric oxide ·≈–‰¡à¡’ƒ∑∏‘χªìπ phosphodiesterase »÷°…“¥â«¬«‘∏’ Hershberger assay ‡ªìπ‡«≈“ 5 «—π
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inhibitor æ∫«à“°≈ÿà¡∑’ˉ¥â√—∫°√–™“¬¥”¡’πÈ”Àπ—°μ—«‡æ‘Ë¡¢÷Èπ„π 24
1.4 º≈μàÕ‡Õπ‰´¡å phosphodiesterase ·≈– 48 ™—Ë«‚¡ßÀ≈—ß„Àâ§√—Èß·√° (P<0.05) À≈—ß®“°

type 5 (PDE5) ∑¥≈Õß·¬° “√®“°‡Àßâ“°√–™“¬¥” π—Èπæ∫«à“‰¡à·μ°μà“ß®“°°≈ÿࡧ«∫§ÿ¡ ·≈–‰¡à¡’
¥â«¬«‘∏’ two-step radioactive assay æ∫«à“ “√ °—¥ §«“¡·μ°μà“ߢÕßπÈ”Àπ—°¢ÕßÕ«—¬«– ◊∫æ—π∏ÿå, ‰¡à„™à
50 μg/ml ¡’ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å PDE5 ·≈– Õ«—¬«– ◊∫æ—π∏ÿå, √–¥—∫ FSH, LH, progesterone À√◊Õ

“√ª√–°Õ∫ 7-methoxyflavone 10 ‰¡‚§√‚¡≈“√å corticosterone √–À«à“ß°≈ÿà¡ „π¢≥–∑’Ë glans
¡’ƒ∑∏‘Ϭ—∫¬—Èß∑—Èß PDE5 (‡μ√’¬¡®“°ªÕ¥ÀπŸ‰¡´å) ·≈– penis, √–¥—∫ testosterone ·≈– progesterone

PDE6 (‡μ√’¬¡®“°‡√μ‘𓉰à) “√∑’Ë¡’ƒ∑∏‘Ï·√ß∑’Ë ÿ¥ ¡’·π«‚π⡇æ‘Ë¡¢÷Èπ ·μà LH ≈¥≈ß„π°≈ÿà¡∑’Ë„Àâ
„π°“√¬—∫¬—Èß PDE5 §◊Õ 5,7-dimethoxyflavone °√–™“¬¥” √ÿª‰¥â«à“°√–™“¬¥”‰¡à¡’º≈μàÕ√–∫∫