Page 17 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 1

Journal of Thai Traditional & Alternative Medicine Vol. 11 No. 1 January-April 2013 11

xyflavone · ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“ Candida albicans ¿“¬„π 1-2 ™—Ë«‚¡ßÀ≈—ß„À⬓ ‚¥¬¡’ bioavailability
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·≈–· ¥ßƒ∑∏‘Ïμâ“π‡™◊ÈÕ Mycobacterium Õ¬à“ßÕàÕπ μË”·§à 1-4%, æ∫°√–®“¬‰ª¬—ßÕ«—¬«–¿“¬„πμà“ßÊ
9. ƒ∑∏‘Ïμâ“π°“√‡°‘¥·º≈„π°√–‡æ“–Õ“À“√ ‚¥¬¡’√–¥—∫ Ÿß ÿ¥„πμ—∫ √Õß≈ß¡“§◊Õ‰μ, ¢—∫ÕÕ°
‡¡◊ËÕ„Àâ “√ °—¥°√–™“¬¥”¥â«¬‡Õ∑“πÕ≈„π ∑“ßªí “«–„π√Ÿª¢Õß demethylated, sulfated ·≈–

¢π“¥ 30, 60 ·≈– 120 ¡°./°°. ·°àÀπŸ·√μ æ∫«à“ glucuronidated ·≈–¢—∫ÕÕ°∑“ßÕÿ®®“√–„π√Ÿª¢Õß
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¡’ƒ∑∏‘Ϭ—∫¬—Èß°“√‡°‘¥·º≈„π°√–‡æ“–Õ“À“√‡π◊ËÕß®“° demethylated form
‰¥â√—∫¬“Õ‘π‚¥‡¡∑“´‘π À√◊Õ°√¥‡°≈◊Õ√à«¡°—∫
√“¬ß“π°“√«‘®—¬∑“ߧ≈‘π‘°
·Õ≈°ÕŒÕ≈åÀ√◊Õ®“°§«“¡‡§√’¬¥¥â«¬°“√„ÀâÕ¬Ÿà„π∑’Ë
·§∫√à«¡°—∫°“√·™à„ππÈ” ‚¥¬‰¡à¡’º≈μàÕª√‘¡“μ√ 1. º≈μàÕ physical fitness „πºŸâ ŸßÕ“¬ÿ

¢ÕßπÈ”¬àÕ¬„π°√–‡æ“– §à“§«“¡‡ªìπ°√¥ (pH) ·≈– ∑¥ Õ∫„πÕ“ “ ¡—§√ ŸßÕ“¬ÿ ÿ¢¿“楒®”π«π
°“√À≈—Ëß°√¥ ·μà√—°…“°“√À≈—Ë߇¡◊Õ°„π°√–‡æ“– (gas- 45 √“¬ ‚¥¬ ÿà¡„Àâ√—∫ª√–∑“π¬“À≈Õ°À√◊Õ “√ °—¥
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tric mucus) °√–™“¬¥”À¬“∫ª√‘¡“≥ 25 À√◊Õ 90 ¡°./«—π‡ªìπ‡«≈“
10. º≈μàÕ cytochrome P450 enzymes 8 —ª¥“Àå »÷°…“º≈μàÕ ¡√√∂¿“æ√à“ß°“¬ (health-
‡¡◊ËÕ»÷°…“„π microsome ∑’ˇμ√’¬¡®“°μ—∫ related physical fitness) ‚¥¬„Àâπ—Ëß-¬◊π 30 «‘π“∑’,

ÀπŸ∂’∫®—°√ æ∫«à“ “√ °—¥°√–™“¬¥”¡’º≈μàÕ °“√«—¥·√ß∫’∫¡◊Õ, √–¬–∑“ß∑’ˇ¥‘π„π 6 π“∑’·≈–
CYP1A2 ·≈– CYP2B ·≈–‡¡◊ËÕ„ÀâÀπŸ∂’∫®—°√°‘π √–¬–‡«≈“∑’ˬ◊π‚¥¬«“߇∑â“μàÕ°—π ≈—∫´â“¬¢«“ ·≈–
“√ °—¥¢π“¥ 250 ¡°./°°. π“π 7, 14 ·≈– 21 «—π ‡¡◊ËÕ≈◊¡μ“·≈–À≈—∫μ“ (tandem stance test),

æ∫«à“‰¡à¡’º≈μàÕ CYP3A activity ·μà¡’º≈°√–μÿâπ «‘‡§√“–Àåª√‘¡“≥ malondialdehde (MDA) ‡Õπ‰´¡å
activities ¢Õß CYP1A1, CYP1A2 À≈—߉¥â√—∫ “√ superoxide dismutase (SOD), catalase (CAT),
°—¥™à«ß‡«≈“ —ÈπÊ, à«π activity ¢Õß CYP2B ·≈– glutathione peroxidase (GSH-Px) æ∫«à“

‡æ‘Ë¡¢÷Èπμ≈Õ¥∑ÿ°™à«ß‡«≈“∑’Ë„Àâ “√ °—¥, ¢≥–∑’Ë acti- °√–™“¬¥”™à«¬‡æ‘Ë¡ ¡√√∂¿“æ„π°“√π—Ëß-¬◊π 30
vity ¢Õß CYP2E1 ‡æ‘Ë¡¢÷Èπ‡©æ“–‡¡◊ËÕ„Àâ “√ °—¥ «‘π“∑’·≈–‡¥‘π 6 π“∑’ æ√âÕ¡°—∫‡æ‘Ë¡ activity ¢Õß
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‡ªìπ‡«≈“π“π‡∑à“π—Èπ scavengerenzymes ∑ÿ°™π‘¥¢â“ßμâπ ¢≥–∑’Ë√–¥—∫
11. ‡¿ —™®≈π»“ μ√å¢Õß “√°≈ÿà¡ Metho- MDA ≈¥≈ß ¥—ßπ—Èπ°√–™“¬¥”®÷ߙ૬‡æ‘Ë¡§«“¡·¢Áß
xyflavones „πÀπŸ·√μ ·√ß√à“ß°“¬„πºŸâ ŸßÕ“¬ÿ à«πÀπ÷Ë߇π◊ËÕß®“°ƒ∑∏‘Ï≈¥¿“«–
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®“°√“¬ß“π°“√»÷°…“‡¿ —™®≈π»“ μ√å¢Õß oxidative stress
“√ °—¥‡Õ∑“πÕ≈„πÀπŸ∂’∫®—°√‚¥¬„Àâ “√ °—¥¢π“¥ 2. º≈‡©’¬∫æ≈—π¢Õß°√–™“¬¥”μàÕ§«“¡
750 ¡°./°°. ∑“ߪ“° μ‘¥μ“¡ “√°≈ÿà¡ methoxy- “¡“√∂„π°“√ÕÕ°°”≈—ß°“¬

flavones ‚¥¬‡©æ“–Õ¬à“߬‘Ëß 5,7-dimethoxyflavone √“¬ß“π°“√»÷°…“º≈‡©’¬∫æ≈—π¢Õß°√–™“¬
(DMF), 5,7,4'-trimethoxyflavone (TMF), and ¥”·§ª´Ÿ≈‡∑’¬∫°—∫¬“À≈Õ°μàÕ§«“¡ “¡“√∂„π°“√

3,5,7,3',4'-pentamethoxyflavone (PMF) æ∫«à“ ÕÕ°°”≈—ß°“¬ ‚¥¬°“√»÷°…“·√°∑¥ Õ∫º≈μàÕ°“√
“√ methoxyflavones ¢÷Èπ∂÷ß√–¥—∫ Ÿß ÿ¥„π‡≈◊Õ¥ ªíòπ®—°√¬“π‡√Á«∑’Ë ÿ¥π“π 30 «‘π“∑’ μàÕ°—π 3 §√—Èß