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96   «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ°                                 ªï∑’Ë 9©∫—∫∑’Ë 2°—𬓬π-∏—𫓧¡ 2554



             ‰∑¬ª√–¬ÿ°μ剥⡒°“√¥—¥·ª≈ßπ”¡“„™â‡©æ“– à«π∑’ˇªìπÀ≈—°  ‚∑… ®÷ß∑”„À⺟â∑’Ë„™â·π«∑“ߢÕß OCEBM π—Èπ à«π¡“°®–‡ªìπ

             ∞“π‡°’Ë¬«°—∫ª√– ‘∑∏‘º≈„π°“√√—°…“ °“√ªÑÕß°—π‚√§ °“√  ·æ∑¬å ‡π◊ËÕß®“°¡’§«“¡√Ÿâ∑’ˇ撬ßæÕ„π°“√π”√–¥—∫¢Õߧ”
             »÷°…“‡°’ˬ«°—∫ “‡Àμÿ¢Õß‚√§ ·≈–Õ—πμ√“¬®“°°“√„™â πÕ°  ·π–π”∑’ˉ¥â®“° OCEBM ‰ªª√–°Õ∫°“√μ—¥ ‘π„® ∑—Èßπ’È
             ®“°π’ȉ¥â¡’°“√μ—¥√–¥—∫¢ÕßÀ≈—°∞“π∫“ß√–¥—∫ÕÕ°‡æ◊ËÕ„Àâ  √–¥—∫¢Õߧ”·π–π”¢Õß OCEBM  “¡“√∂𔉪‡∑’¬∫‡§’¬ß

             ‡À¡“– ¡°—∫°“√ª√–‡¡‘πÀ≈—°∞“π∑’ˇ°’ˬ«¢âÕß°—∫°“√√—°…“¥â«¬  °—∫√–∫∫Õ◊Ëπ ®÷ßÕ“®Õ∏‘∫“¬‰¥â«à“√–¥—∫ A = ¡’ª√–‚¬™πå, B =
             »“ μ√å°“√·æ∑¬å·ºπ‰∑¬ (μ“√“ß∑’Ë 1)                  πà“®–¡’ª√–‚¬™πå, C = ‰¡àπà“®–¡’ª√–‚¬™πå, D = ‰¡à∑√“∫«à“
                                                                                6
                 Õ¬à“߉√°Á¥’ ·π«∑“ߢÕß OCEBM °Á¡’¢âÕ¥âÕ¬∑’Ë ”§—≠§◊Õ  ¡’ª√– ‘∑∏‘º≈À√◊Õ‰¡à
             ‰¡à¡’°“√∫Õ°«à“√–¥—∫¢Õߧ”·π–π”π—Èπ “¡“√∂π”¡“„™â∑“߇«™    ¥—ßπ—Èπ „πªïæ.».2554 OCEBM ®÷߉¥â®—¥∑”‡°≥±å
             °√√¡‰¥âÕ¬à“߉√ ·≈–‰¡à¡’°“√ √ÿª«à“¢âÕ¡Ÿ≈π—Èπ¡’ª√–‚¬™πåÀ√◊Õ  OCEBM 2011 levels of evidence (μ“√“ß∑’Ë 2) ¢÷Èπ¡“„À¡à




             μ“√“ß∑’Ë 2 √–¥—∫¢ÕßÀ≈—°∞“πμ“¡·π«∑“ߢÕß OCEBM 2011 (OCEBM 2011 Levels of Evidence)

                              ¢—ÈπμÕπ∑’Ë  1   ¢—ÈπμÕπ∑’Ë  2   ¢—ÈπμÕπ∑’Ë  3      ¢—ÈπμÕπ∑’Ë  4     ¢—ÈπμÕπ∑’Ë 5
             §”∂“¡
                              (√–¥—∫ 1*)      (√–¥—∫ 2*)      (√–¥—∫ 3*)         (√–¥—∫ 4*)        (√–¥—∫ 5*)
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             ªí≠À“π’Èæ∫∫àÕ¬ °“√ ”√«®·∫∫ ÿà¡„π Systematic review ¢Õß °“√ ”√«®„π∑âÕß∑’Ë‚¥¬ ß“π«‘®—¬™π‘¥ case-series  ‰¡à¡’
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             ‡∑à“„¥        ∑âÕß∑’Ë ≥ ‡«≈“π—Èπ  °“√ ”√«®´÷Ëßμ√ß°—∫ ‰¡à¡’°“√ ÿà¡μ—«Õ¬à“ß
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                                           ∂“π°“√≥å¢Õß∑âÕß∂‘Ëπ
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             °“√«‘π‘®©—¬π’È∂Ÿ° Systematic review ß“π«‘®—¬·∫∫ cross °“√»÷°…“∑’ˉ¡à¡’§«“¡μàÕ ß“π«‘®—¬™π‘¥ case-control  ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
             μâÕ߇撬߄¥ (°“√ ¢Õßß“π«‘®—¬·∫∫ cross section ∑’Ë¡’°“√≈¥Õ§μ‘ ‡π◊ËÕß À√◊Õ °“√»÷°…“∑’Ë  ‚¬ß°“√„Àâ°“√√—°…“°—∫
             «‘π‘®©—¬)     section ∑’Ë¡’°“√≈¥Õ§μ‘         ‰¡à¡’°“√„™â reference stan-          º≈∑“ߧ≈‘π‘° (mecha-
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                                                          dard                                 nism-based reasoning)
             ∂Ⓣ¡à„Àâ°“√√—°…“ Systematic review ß“π«‘®—¬ Inception co- ß“π«‘®—¬ Cohort À√◊Õ °≈ÿà¡ ß“π«‘®—¬·∫∫ case-series  ‰¡à¡’
             ®–‡°‘¥º≈Õ¬à“߉√ ¢Õßß“π«‘®—¬ Inception hort   §«∫§ÿ¡¢Õß randomized À√◊Õ case-control À√◊Õ
             (°“√欓°√≥å‚√§) cohort                       trial*            ß“π«‘®—¬ cohort ∑’Ë¥âÕ¬
                                                                            §ÿ≥¿“æ
             °“√√—°…“π’È¡’º≈¥’ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series  ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
             Õ¬à“߉√       RCT             —߇°μ∑’Ë¡’§ÿ≥¿“æ   ÿà¡μ—«Õ¬à“ß À√◊Õ°“√»÷°…“ À√◊Õ case-control À√◊Õ  ‚¬ß°“√„Àâ°“√√—°…“°—∫
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                                                          ·∫∫μ‘¥μ“¡º≈       historical case -control  º≈∑“ߧ≈‘π‘°
             º≈‡ ’¬∑’Ëæ∫‰¥â∫àÕ¬ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series  ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
             ®“°°“√√—°…“π’ȧ◊Õ RCT À√◊Õ °“√«‘®—¬‡™‘ß  —߇°μ∑’Ë¡’§ÿ≥¿“æ   ÿà¡μ—«Õ¬à“ß À√◊Õ °“√»÷°…“ À√◊Õ case-control À√◊Õ  ‚¬ß°“√„Àâ°“√√—°…“°—∫
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             Õ–‰√           —߇°μ∑’Ë¡’§ÿ≥¿“æ              ·∫∫μ‘¥μ“¡º≈       historical case -control  º≈∑“ߧ≈‘π‘°
             º≈‡ ’¬∑’Ëæ∫‰¥âπâÕ¬ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series  ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
             ®“°°“√√—°…“π’ȧ◊Õ RCT         —߇°μ∑’Ë¡’§ÿ≥¿“æ   ÿà¡μ—«Õ¬à“ß À√◊Õ °“√ À√◊Õ case-control À√◊Õ  ‚¬ß°“√„Àâ°“√√—°…“°—∫
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             Õ–‰√                                         »÷°…“·∫∫μ‘¥μ“¡º≈  historical case -control  º≈∑“ߧ≈‘π‘°
             °“√μ√«®π’ȧÿâ¡§à“ Systematic review ¢Õß RCT  ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series  ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
             À√◊Õ‰¡à (°“√μ√«® RCT                          ÿà¡μ—«Õ¬à“ß À√◊Õ °“√ À√◊Õ case-control À√◊Õ  ‚¬ß°“√„Àâ°“√√—°…“°—∫
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             „π√–¬–‡√‘Ë¡·√°                               »÷°…“·∫∫μ‘¥μ“¡º≈  historical case -control  º≈∑“ߧ≈‘π‘°
             °“√§—¥°√Õß)
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             À¡“¬‡Àμÿ : ¥—¥·ª≈ß®“° The Oxford 2011 Levels of Evidence
                     * √–¥—∫¢ÕßÀ≈—°∞“πÕ“®≈¥≈ß ¢÷ÈπÕ¬Ÿà°—∫§ÿ≥¿“æ §«“¡‰¡à™—¥‡®π ‡π◊ËÕß®“°§«“¡¢—¥·¬âß°—π√–À«à“ß°“√»÷°…“ À√◊Õ®”π«πμ—«Õ¬à“ß∑’Ë„Àâº≈πâÕ¬‡°‘π‰ª „π∑“ßμ√ß°—π¢â“¡
                      √–¥—∫¢ÕßÀ≈—°∞“πÕ“®‡æ‘Ë¡¢÷Èπ‰¥â∂â“®”π«πμ—«Õ¬à“ß∑’Ë„Àâº≈¡’®”π«π¡“°
                     #„π°√≥’∑’ËÀ“ systematic review ¢Õßß“π«‘®—¬‡À≈à“π’ȉ¥â ®–¡’§«“¡πà“‡™◊ËÕ∂◊Õ°«à“ß“π«‘®—¬‡¥’ˬ«
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