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96 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë 9©∫—∫∑’Ë 2°—𬓬π-∏—𫓧¡ 2554
‰∑¬ª√–¬ÿ°μ剥⡒°“√¥—¥·ª≈ßπ”¡“„™â‡©æ“– à«π∑’ˇªìπÀ≈—° ‚∑… ®÷ß∑”„À⺟â∑’Ë„™â·π«∑“ߢÕß OCEBM π—Èπ à«π¡“°®–‡ªìπ
∞“π‡°’Ë¬«°—∫ª√– ‘∑∏‘º≈„π°“√√—°…“ °“√ªÑÕß°—π‚√§ °“√ ·æ∑¬å ‡π◊ËÕß®“°¡’§«“¡√Ÿâ∑’ˇ撬ßæÕ„π°“√π”√–¥—∫¢Õߧ”
»÷°…“‡°’ˬ«°—∫ “‡Àμÿ¢Õß‚√§ ·≈–Õ—πμ√“¬®“°°“√„™â πÕ° ·π–π”∑’ˉ¥â®“° OCEBM ‰ªª√–°Õ∫°“√μ—¥ ‘π„® ∑—Èßπ’È
®“°π’ȉ¥â¡’°“√μ—¥√–¥—∫¢ÕßÀ≈—°∞“π∫“ß√–¥—∫ÕÕ°‡æ◊ËÕ„Àâ √–¥—∫¢Õߧ”·π–π”¢Õß OCEBM “¡“√∂𔉪‡∑’¬∫‡§’¬ß
‡À¡“– ¡°—∫°“√ª√–‡¡‘πÀ≈—°∞“π∑’ˇ°’ˬ«¢âÕß°—∫°“√√—°…“¥â«¬ °—∫√–∫∫Õ◊Ëπ ®÷ßÕ“®Õ∏‘∫“¬‰¥â«à“√–¥—∫ A = ¡’ª√–‚¬™πå, B =
»“ μ√å°“√·æ∑¬å·ºπ‰∑¬ (μ“√“ß∑’Ë 1) πà“®–¡’ª√–‚¬™πå, C = ‰¡àπà“®–¡’ª√–‚¬™πå, D = ‰¡à∑√“∫«à“
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Õ¬à“߉√°Á¥’ ·π«∑“ߢÕß OCEBM °Á¡’¢âÕ¥âÕ¬∑’Ë ”§—≠§◊Õ ¡’ª√– ‘∑∏‘º≈À√◊Õ‰¡à
‰¡à¡’°“√∫Õ°«à“√–¥—∫¢Õߧ”·π–π”π—Èπ “¡“√∂π”¡“„™â∑“߇«™ ¥—ßπ—Èπ „πªïæ.».2554 OCEBM ®÷߉¥â®—¥∑”‡°≥±å
°√√¡‰¥âÕ¬à“߉√ ·≈–‰¡à¡’°“√ √ÿª«à“¢âÕ¡Ÿ≈π—Èπ¡’ª√–‚¬™πåÀ√◊Õ OCEBM 2011 levels of evidence (μ“√“ß∑’Ë 2) ¢÷Èπ¡“„À¡à
μ“√“ß∑’Ë 2 √–¥—∫¢ÕßÀ≈—°∞“πμ“¡·π«∑“ߢÕß OCEBM 2011 (OCEBM 2011 Levels of Evidence)
¢—ÈπμÕπ∑’Ë 1 ¢—ÈπμÕπ∑’Ë 2 ¢—ÈπμÕπ∑’Ë 3 ¢—ÈπμÕπ∑’Ë 4 ¢—ÈπμÕπ∑’Ë 5
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(√–¥—∫ 1*) (√–¥—∫ 2*) (√–¥—∫ 3*) (√–¥—∫ 4*) (√–¥—∫ 5*)
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ªí≠À“π’Èæ∫∫àÕ¬ °“√ ”√«®·∫∫ ÿà¡„π Systematic review ¢Õß °“√ ”√«®„π∑âÕß∑’Ë‚¥¬ ß“π«‘®—¬™π‘¥ case-series ‰¡à¡’
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‡∑à“„¥ ∑âÕß∑’Ë ≥ ‡«≈“π—Èπ °“√ ”√«®´÷Ëßμ√ß°—∫ ‰¡à¡’°“√ ÿà¡μ—«Õ¬à“ß
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∂“π°“√≥å¢Õß∑âÕß∂‘Ëπ
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°“√«‘π‘®©—¬π’È∂Ÿ° Systematic review ß“π«‘®—¬·∫∫ cross °“√»÷°…“∑’ˉ¡à¡’§«“¡μàÕ ß“π«‘®—¬™π‘¥ case-control ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
μâÕ߇撬߄¥ (°“√ ¢Õßß“π«‘®—¬·∫∫ cross section ∑’Ë¡’°“√≈¥Õ§μ‘ ‡π◊ËÕß À√◊Õ °“√»÷°…“∑’Ë ‚¬ß°“√„Àâ°“√√—°…“°—∫
«‘π‘®©—¬) section ∑’Ë¡’°“√≈¥Õ§μ‘ ‰¡à¡’°“√„™â reference stan- º≈∑“ߧ≈‘π‘° (mecha-
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dard nism-based reasoning)
∂Ⓣ¡à„Àâ°“√√—°…“ Systematic review ß“π«‘®—¬ Inception co- ß“π«‘®—¬ Cohort À√◊Õ °≈ÿà¡ ß“π«‘®—¬·∫∫ case-series ‰¡à¡’
®–‡°‘¥º≈Õ¬à“߉√ ¢Õßß“π«‘®—¬ Inception hort §«∫§ÿ¡¢Õß randomized À√◊Õ case-control À√◊Õ
(°“√欓°√≥å‚√§) cohort trial* ß“π«‘®—¬ cohort ∑’Ë¥âÕ¬
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°“√√—°…“π’È¡’º≈¥’ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
Õ¬à“߉√ RCT —߇°μ∑’Ë¡’§ÿ≥¿“æ ÿà¡μ—«Õ¬à“ß À√◊Õ°“√»÷°…“ À√◊Õ case-control À√◊Õ ‚¬ß°“√„Àâ°“√√—°…“°—∫
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·∫∫μ‘¥μ“¡º≈ historical case -control º≈∑“ߧ≈‘π‘°
º≈‡ ’¬∑’Ëæ∫‰¥â∫àÕ¬ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
®“°°“√√—°…“π’ȧ◊Õ RCT À√◊Õ °“√«‘®—¬‡™‘ß —߇°μ∑’Ë¡’§ÿ≥¿“æ ÿà¡μ—«Õ¬à“ß À√◊Õ °“√»÷°…“ À√◊Õ case-control À√◊Õ ‚¬ß°“√„Àâ°“√√—°…“°—∫
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Õ–‰√ —߇°μ∑’Ë¡’§ÿ≥¿“æ ·∫∫μ‘¥μ“¡º≈ historical case -control º≈∑“ߧ≈‘π‘°
º≈‡ ’¬∑’Ëæ∫‰¥âπâÕ¬ Systematic review ¢Õß RCT À√◊Õ°“√«‘®—¬‡™‘ß ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
®“°°“√√—°…“π’ȧ◊Õ RCT —߇°μ∑’Ë¡’§ÿ≥¿“æ ÿà¡μ—«Õ¬à“ß À√◊Õ °“√ À√◊Õ case-control À√◊Õ ‚¬ß°“√„Àâ°“√√—°…“°—∫
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Õ–‰√ »÷°…“·∫∫μ‘¥μ“¡º≈ historical case -control º≈∑“ߧ≈‘π‘°
°“√μ√«®π’ȧÿâ¡§à“ Systematic review ¢Õß RCT ß“π«‘®—¬ Cohort ∑’ˉ¡à¡’°“√ ß“π«‘®—¬·∫∫ case-series ¢âÕ √ÿª∑’ˉ¥â®“°°“√‡™◊ËÕ¡
À√◊Õ‰¡à (°“√μ√«® RCT ÿà¡μ—«Õ¬à“ß À√◊Õ °“√ À√◊Õ case-control À√◊Õ ‚¬ß°“√„Àâ°“√√—°…“°—∫
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„π√–¬–‡√‘Ë¡·√° »÷°…“·∫∫μ‘¥μ“¡º≈ historical case -control º≈∑“ߧ≈‘π‘°
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À¡“¬‡Àμÿ : ¥—¥·ª≈ß®“° The Oxford 2011 Levels of Evidence
* √–¥—∫¢ÕßÀ≈—°∞“πÕ“®≈¥≈ß ¢÷ÈπÕ¬Ÿà°—∫§ÿ≥¿“æ §«“¡‰¡à™—¥‡®π ‡π◊ËÕß®“°§«“¡¢—¥·¬âß°—π√–À«à“ß°“√»÷°…“ À√◊Õ®”π«πμ—«Õ¬à“ß∑’Ë„Àâº≈πâÕ¬‡°‘π‰ª „π∑“ßμ√ß°—π¢â“¡
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#„π°√≥’∑’ËÀ“ systematic review ¢Õßß“π«‘®—¬‡À≈à“π’ȉ¥â ®–¡’§«“¡πà“‡™◊ËÕ∂◊Õ°«à“ß“π«‘®—¬‡¥’ˬ«