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             Journal of Thai Traditional & Alternative Medicine                      Vol. 8 Nos. 2-3 May-December 2010 Òı˜
             control ‚¥¬ orilstat ∑’˧«“¡‡¢â¡¢âπ .Úı mM  “¡“√∂  μ“√“ß∑’Ë ˆ º≈¢Õß “√ °—¥®“°„∫™–¡«ß ∑’˧«“¡‡¢â¡¢âπ Ò ¡§°./
                                                                         ¡≈. μàÕ°“√∑”ß“π¢Õ߇Õπ‰´¡å HMG CoA reductase
             ¬—∫¬—Èß°“√∑”ß“π¢Õß pancreatic lipase ‰¥â√âÕ¬≈– ˘Û.ÚÛ
             º≈°“√¬—∫¬—Èß°“√∑”ß“π¢Õ߇Õπ‰´¡å pancreatic lipase ¢Õß                              % °“√¬—∫¬—È߇Õπ‰´¡å
                                                                 ≈”¥—∫∑’Ë        “√ °—¥
              “√ °—¥®“°„∫™–¡«ß· ¥ß„π μ“√“ß∑’Ë ı æ∫«à“  “√ °—¥ GC-                              HMG-CoA reductase
             2  “¡“√∂¬—∫¬—Èß°“√∑”ß“π¢Õ߇Õπ‰´¡å‰¥â¥’∑’Ë ÿ¥¥â«¬§à“ IC50  Ò         GC-1            ˘˜.ˆ ± ˘.ÛÒ
             ‡∑à“°—∫ ˆ˜.Ùı ¡§°./¡≈.                                Ú             GC-2           ÒÒÙ.ÛÙ ± ÚÙ.ÙÛ
                 ˆ. º≈μàÕ°“√¬—∫¬—Èß°“√∑”ß“π¢Õ߇Õπ‰´¡å HMG CoA      Û             GC-3            ¯.ıı ± Òˆ.ˆı

             reductase                                             Ù             GC-4            ¯.Ú˜ ± Ù.ˆÛ
                 ®“°°“√»÷°…“º≈°“√¬—∫¬—Èß°“√∑”ß“π¢Õ߇Õπ‰´¡å HMG     ı             GC-5            ıˆ.Ò¯ ± ÒÒ.ˆÙ





             μ“√“ß∑’Ë ˜ 500 MHz 1H NMR ·≈– 125 MHz 13C NMR  ‡ª°μ√—¡¢Õß vitexin ·≈– orientin („π CD3OD+DMSO-d6)

                                                  Ò,ÒÒ                                        ÒÒ
                                             Vitexin                                     Orientin
             μ”·Àπàß
                                      δ  ppm                δ  ppm                δ  ppm                δ  ppm
                                       H                     C                      H                    C
                2                       -                  163.96                    -                  164.08

                3                  6.63 (1H, s)            102.44               6.63 (1H, s)            102.44
                4                       -                  182.10                    -                  182.02
                5                       -                  161.13                    -                  161.13
              5-OH                 13.15 (1H, s)              -                13.15 (1H, s)              -

                6                  6.26 (1H, s)             98.13               6.25 (1H, s)            98.13
                7                       -                  162.55                    -                  163.96
              7-OH                 10.84 (1H, s)              -                      -                    -
                8                       -                  104.60                    -                  104.60
                9                       -                  155.99                    -                  155.99
               10                       -                  104.03                    -                  104.03
                1′                      -                  121.61                    -                  121.61
                2′             8.01 (1H, d, J = 8.5 Hz)    128.97               7.47 (1H, s)            114.04
                3′             6.88 (1H, d, J = 8.5 Hz)    115.81                    -                  145.80
                4′                      -                  160.38                    -                  149.60

              4′-OH                10.35 (1H, s)              -                      -                    -
                5′             6.88 (1H, d, J = 8.5 Hz)    115.81          6.85 (1H, d, J = 8.5 Hz)     115.64
                6′             8.01 (1H, d, J = 8.5 Hz)    128.97          7.52 (1H, d, J = 8.5 Hz)     119.36

              Glc-1            4.67 (1H, d, J = 9.5 Hz)     73.38          4.67 (1H, d, J = 9.5 Hz)     73.38
              Glc-2            3.82 (1H, t, J = 9.3 Hz )    70.83          3.82 (1H, t, J = 9.3 Hz )    70.76
              Glc-3                                         78.66                                       78.75
              Glc-4                  3.0-3.6                70.54                 3.0-3.6               70.69

              Glc-5                                         81.84                                       81.98
              Glc-6                                         61.29                                       61.63
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