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‰¥â√—∫ bixin 8.5 ¡°./°°./«—π ´÷Ëß Ÿß°«à“ ADI ¢Õß “√ °—¥·Õπ·πµ‚µ„π√Ÿª bixin ∂÷ß 131 ‡∑à“
æ∫«à“ ®”π«π¢ÕßÀπŸ∑’Ë¡’‡´≈≈åµ—∫‡ ◊ËÕ¡·∫∫‰¢¡—π‡æ‘Ë¡¢÷Èπ (5/15) ·µà°“√‡ª≈’ˬπ·ª≈ßπ’ÈÕ¬Ÿà„π√–¥—∫

‡≈Á°πâÕ¬ (mild fatty change) ·≈–‰¡à¡’º≈µàÕ§à“ liver enzymes ‡π◊ËÕß®“°§à“ ADI ¢Õß “√ °—¥
(8)
annatto ∑’Ë WHO °”À𥉫â„π√Ÿª¢Õß “√ bixin §◊Õ 0-0.065 ¡°./°°./«—π ¥—ßπ—ÈπÀ“°„™â “√ °—¥
‡¡≈Á¥§”· ¥‡ªìπ feed additive §«√„™â„πª√‘¡“≥∑’ËæÕ‡À¡“–‰¡à Ÿß¡“°‡°‘π‰ª·≈–§«√¡’°“√µ√«®
chemical contents Õ◊ËπÊ∑’Ë ”§—≠ ‡™àπ norbixin ‡æ◊ËÕª√—∫„™â„π¢π“¥∑’ˇÀ¡“– ¡ ”À√—∫º ¡
Õ“À“√·µà≈–ª√–‡¿∑µàÕ‰ª

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1) «—π¥’ °ƒ…≥æ—π∏å 2538. ¡ÿπ‰æ√ “√æ—¥ª√–‚¬™πå ¿“§«‘™“‡¿ —™«‘π‘®©—¬ §≥–‡¿ —™»“ µ√å
¡À“«‘∑¬“≈—¬¡À‘¥≈ Àπâ“ 186-7.

2) Evans WC Annatto: a natural choice. Biologist 2000;47(4): 181-4.
3) Kroes R. and Verger P. Annatto Extracts. Available from htpp:/www. whqlibdoc.
who.int/publications /2004/924a66052x.pdf.

4) «ÿ≤‘ «ÿ≤‘∏√√¡‡«™. “√“πÿ°√¡ ¡ÿπ‰æ√ √«¡À≈—°‡¿ —™°√√¡‰∑¬ ‚Õ ‡Õ æ√‘Èπµ‘Èß ‡Œâ“ å
°√ÿ߇∑æ¡À“π§√ 2540 : 153.
5) ‚§√ß°“√æ—≤π“‡∑§π‘§∑”¬“ ¡ÿπ‰æ√ °“√„™â ¡ÿπ‰æ√ ∫√‘…—∑ “√¡«≈™π ®”°—¥ °√ÿ߇∑æœ 2524

: 47-48.
6) Canadian center for occupational health and safety. What is and LD50 and LC
50.2005. Available from htpp: // www.ccohs.ca/oshanswers/chemicals/ld50.html 2005.
7) Gad SC. The RAT: Pathology. In: Gad SC and Chengelis CP, ed. Animal Model in

Toxicology. New York: Marcel Dekker 1992; 78-81,95.
8) WHO 1982. Evaluation of certain food additives and contaminants. Technical Report
Series 683 p.42.