Page 48 - วารสารการแพทย์แผนไทย ปีที่ 21 ฉบับที่ 2

264 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 2 พฤษภาคม-สิงหาคม 2566

ข้อสรุปและข้อเสนอแนะ: ผลการศึกษาแสดงให้เห็นว่า สามารถเลือกใช้ยาธาตุบรรจบเป็นยาลำาดับแรก ใน
การบรรเทาอาการท้องอืดไม่ทราบสาเหตุทดแทนยาไซเมทิโคนได้ และผลข้างเคียงที่พบต้องมีการศึกษาทางคลินิก
ในระยะยาวร่วมด้วย
คำ�สำ�คัญ: ยาธาตุบรรจบ, ยาไซเมทิโคน, อาการท้องอืดไม่ทราบสาเหตุ

A Comparative Study on the Efficacy and Side Effects of Ya That Banchop and
Simethicone in Treatment of Patients with Functional Dyspepsia at HM The
King’s 6th Cycle Birthday Chaloem Phra Kiat Health Center, Pathum Thani

Worakan Mukpradab , Thavatchai Kamoltham †
*,‡
Graduate School, Suan Sunandha Rajabhat University, Dusit Subdistrict, Dusit District, Bangkok 10300, Thailand
*
College of Allied Health Science, Suan Sunandha Rajabhat University, Dusit Subdistrict, Dusit District, Bangkok 10300,
†
Thailand
‡ Corresponding author: jangieworakan@gmail.com

Abstract
Introduction and Objectives: At present, dyspepsia is the most common condition of gastrointestinal diseases;
and in the primary care system it is diagnosed as Functional Dyspepsia (FD). This study, therefore, aimed to explore
the efficacy, side effects, and quality of life of the patients who took either Thai herbal drug Ya That Banchop (YTB)
or simethicone usually prescribed to treat flatulence. It is hoped that the results of the study will provide important
information to support the use of YTB in the treatment of flatule nce in the future.
Methods: This clinical trial involved 80 patients with FD or idiopathic chronic flatulence. All participants were
divided into two groups, 40 each: the experimental group receiving YTB and the control group receiving simethicone.
Each participant took 1 capsule before meals for 7 days and used the Severity of Dyspepsia Assessment (SODA)
questionnaire, Naranjo’s ADR algorithm, and the abbreviated World Health Organization Quality of Life Assessment
Questionnaire. Data were analyzed using descriptive statistics; and basic statistics were calculated for paired samples
t-test and independent samples t-test.
Results: A comparison of the efficacy of YTB and simethicone in the treatment of FD patients before and after
meals showed no significant difference (p-value < 0.001) with SODA average scores of -5.32 ± 3.63 and -7.82 ± 2.89,
respectively. Both groups had medication side effects including frequent hunger, 22.5% and 10%, respectively, and
insomnia, 0% and 10%, respectively. The overall quality of life scores in both groups before and after taking medica-
tions were not significantly different, with average scores of 9.82 ± 3.38 and 8.57 ± 3.30, respectively.
Discussion: A comparison of the efficacy of YTB and simethicone in treating idiopathic flatulence before and
after meals showed no significant difference (p < 0.001). Side effects including frequent hunger and constipation were
reported after taking YTB, while pain and insomnia were reported after simethicone medication. The overall quality of
life scores in both groups before and after taking the drugs were not statistically different (p < 0.001).
Conclusion: Ya That Banchop can be the first choice for relieving functional dyspepsia, while simethicone can
be substituted. And its side effects require long-term
Key words: Ya That Banchop, simethicone, functional dyspepsia