Page 7 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 2 ฉบับที่ 3

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„πµ”√“¬“·ºπ‚∫√“≥¢Õ߉∑¬‰¥â°≈à“«∂÷ß∫—«∫°«à“ „∫„™â√—∫ª√–∑“π‡ªìπÕ“À“√‰¥â à«π

ª√–‚¬™πå∑“߬“π—È𠇪ìπ¬“∫”√ÿß √—°…“‚√§º‘«Àπ—ß ‚√§‡ âπª√– “∑ ¢—∫ªí “«– µâπ·≈–„∫‡ªìπ¬“
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∫”√ÿßÀ—«„® ·°âÕàÕπ‡æ≈’¬ ‡¡◊ËÕ¬≈â“ ·°â∑âÕ߇ ’¬ Õ“°“√∫‘¥ ·≈–¬—ß¡’ √√æ§ÿ≥µâ“πÕ—°‡ ∫Õ’°¥â«¬ (7)
(6)
§π®’π„™â∫—«∫°µ”≈–≈“¬πÈ”·≈–πÈ”µ“≈‡ªìππÈ”∑ÿ∫“≈ ·°â√âÕπ„π·°â™È”„π ·°âÕàÕπ‡æ≈’¬‰¥â¥’ à«π„πµ”√“
Õ“¬ÿ√‡«∑¢Õߪ√–‡∑»Õ‘π‡¥’¬π—Èπ„™â∫—«∫°‡ªìπ¬“∫”√ÿß∑—Ë«‰ª ¬“ ß∫ª√– “∑·≈–§≈“¬°—ß«≈ (sedative

(9)
(8)
and anxiolytic) ·≈–∫”√ÿß ¡Õß (brain tonic) °“√»÷°…“∂÷ßÕߧåª√–°Õ∫∑“߇§¡’¢Õß∫—«∫° æ∫
«à“ ¡’ “√ ”§—≠°≈ÿà¡ triterpene saponins ‰¥â·°à asiaticoside ´÷Ëß¡’ sapogenin §◊Õ asiatic acid
‚¥¬ à«π¢ÕßπÈ”µ“≈‡ªìπ rhamnose µàÕ°—∫ glucose 2 ‚¡‡≈°ÿ≈, asiaticoside A ·≈– asiaticoside B
¡’ sapogenin §◊Õ 6-b-hydroxyasiatic acid ·≈– teminolic acid µ“¡≈”¥—∫‚¥¬ à«π¢ÕßπÈ”µ“≈
(11)
(10)
‡À¡◊Õπ°—∫ asiaticoside ∑ÿ°ª√–°“√ Triterpene glycosides Õ◊ËπÊ ‰¥â·°à madecassoside ,
(12)
centellasaponins B ,C ·≈– D ‡ªìπµâπ πÕ°®“°π’È¡’√“¬ß“π«à“ essential oil „π à«π aerial part
¢Õß∫—«∫°¡’ “√°≈ÿà¡ sesquiterpenoids Õ¬Ÿàª√‘¡“≥¡“° ‡™àπb-caryophyllene a-humulene,
germacrene-D œ≈œ (13)
®“°√“¬ß“π°“√»÷°…“ƒ∑∏‘Ï∑“߇¿ —™«‘∑¬“µà“ßÊ¢Õß ¡ÿπ‰æ√∫—«∫°π—Èπ æ∫«à“ “√ asiatic

acid, madecassic acid ·≈– asiaticoside ¢Õß∫—«∫°∑”„Àâ human fibroblast ¡’°“√ —߇§√“–Àå col-
(14)
lagen I ‡æ‘Ë¡¢÷Èπ ´÷Ëß Õ¥§≈âÕß°—∫°“√„™âµ“¡·ºπ‚∫√“≥∑’˙૬„Àâ·º≈À“¬¥’¢÷Èπ “√ °—¥¥â«¬‡Œ°
‡´π ‰¥§≈Õ‚√¡’‡∑π ·≈–‡Õ∏“πÕ≈¢Õß∫—«∫°∑—Èßµâπ¡’ƒ∑∏‘Ï≈¥§«“¡¥—π‡≈◊Õ¥„πÀπŸ¢“«∑’ˇÀπ’ˬ«π”„Àâ¡’
(15)
§«“¡¥—π‡≈◊Õ¥ Ÿß‰¥â‚¥¬°≈‰°°“√ÕÕ°ƒ∑∏‘Ïπà“®–‡°‘¥®“°°“√¢¬“¬À≈Õ¥‡≈◊Õ¥ “√ °—¥¥â«¬‡Õ∏“πÕ≈
(16)
¢Õß∫—«∫°¢π“¥ 100 ¡°./°°. ¡’ƒ∑∏‘ϵâ“𧫓¡‡§√’¬¥‡∑’¬∫‡∑à“°—∫ diazepam 2.5 ¡°./°°. “√
°—¥¥â«¬ 50% ‡Õ∏“πÕ≈¢Õß∫—«∫°¡’ƒ∑∏‘Ï°¥√–∫∫ª√– “∑ à«π°≈“ß·≈–¬—ß¡’ƒ∑∏‘ϵâ“π¿“«–´÷¡‡»√â“

(antidepressant) ‡™àπ‡¥’¬«°—∫ imipramine ·≈– d-amphetamine ‚¥¬ºà“π∑“ß D2 receptor ·≈–
(17)
cholinominetic action ´÷Ëß∂Ÿ° block ¥â«¬ atropine ·≈– chlorpromazine “√ °—¥¥â«¬ 95%
·Õ≈°ÕŒÕ≈å¢Õß√“°∫—«∫° “¡“√∂ªÑÕß°—π°“√‡°‘¥·º≈„π°√–‡æ“–¢ÕßÀπŸ¢“«∑’ˇÀπ’ˬ«π”‚¥¬«‘∏’
(18)
restraint stress ‰¥âÕ¬à“ß¡’π—¬ ”§—≠ ƒ∑∏‘Ï∑’Ëπà“ π„®Õ’°ª√–°“√Àπ÷Ëß §◊Õ “√ °—¥¥â«¬‡¡∏“πÕ≈
(19)
¢Õß∫—«∫° “¡“√∂°“√¬—∫¬—È߇°‘¥‡π◊ÈÕßÕ°∑’Ë°√–µÿâπ‚¥¬ Epsteinbar virus „πÀ≈Õ¥∑¥≈Õ߉¥â¥’ ®“°
√“¬ß“π°“√»÷°…“∑“ߧ≈‘π‘°æ∫«à“ ¢’Ⱥ÷ÈßÀ√◊պ߬“∑’Ë¡’ à«πº ¡¢Õß “√ °—¥∫—«∫°™à«¬‡√àß°“√À“¬¢Õß
·º≈‰¥â ¬“‡µ√’¬¡∑’˺ ¡∫—«∫° “¡“√∂√—°…“·º≈‡√◊ÈÕ√—߉¥â¥’ “√ °—¥∫—«∫°∑”„Àâ·º≈‰ø‰À¡â„π√–¥—∫ 2

·≈– 3 À“¬‡√Á«¢÷Èπ ·≈–ªÑÕß°—π°“√À¥µ—«À√◊Õ°“√∫«¡∑’ˇ°‘¥®“°°“√µ‘¥‡™◊ÈÕ‰¥â Õ’°∑—È߬—߬—∫¬—Èß°“√ √â“ß
(11)
·º≈‡ªìπ∑’ˇ°‘π°«à“√–¥—∫ª°µ‘‰¥â „π°“√∑¥≈Õß„™â total triterpene fraction ®“°∫—«∫°„πºŸâ∑’Ë¡’¿“«–
venous hypertension ∑’Ë¡’Õ“°“√∫«¡¢ÕߢâÕ‡∑â“·≈–ΩÉ“‡∑â“π—Èπ æ∫«à“ “√¥—ß°≈à“«™à«¬≈¥°“√‡æ‘Ë¡

§«“¡ “¡“√∂„π°“√´÷¡ºà“π¢ÕßÀ≈Õ¥‡≈◊Õ¥ΩÕ¬·≈–™à«¬„Àâ°“√‰À≈‡«’¬π¢Õ߇≈◊Õ¥„πÀ≈Õ¥‡≈◊Õ¥
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¢π“¥‡≈Á°¥’¢÷Èπ¥â«¬ ºŸâªÉ«¬∑’Ë¡’·º≈ ulcer „π°√–‡æ“–Õ“À“√·≈–≈”‰ ⇡◊ËÕ‰¥â√—∫ª√–∑“π titrated extract