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ABSTRACT

Oral acute toxcity of Centella asiatica (L.) Urban powder (CA) in mice revealed
that median lethal dose (LD ) of CA was more than 8 g/kg body weight. Histopathologi-
50
cal study revealed no abnormality contributed to CA. Chronic toxicity has been investi-

gated in six groups of Wistar rats, each of 30 rats (15 of each sex). Group 1 was the water
control group while group 2 to 5 received CA by oral administration at the doses of 20,

200, 600 and 1200 mg/kg/day respectively for six months. Group 6, a recovery group,
received 2000 mg/kg CA and the administration was withdrawn two weeks before
sacrificed. The result revealed that average body weight and food consumption in all
CA-treated groups were not different from those of the control groups. Male rats receiving

CA at 600 and 1200 mg/kg had significantly less white blood cell counts than the control
group (p<0.05); however the number of white blood cell increased after CA discontinuation
for 2 weeks. Male rats receiving 600 mg/kg CA and more had significantly higher levels of

sodium and chloride than control group (p<0.05) and female rats treated with 1200 mg/kg
CA had significantly higher sodium level (p<0.05) as well. However, these alterations were
trivial and within normal range. Histopathological study of various visceral organs did not

show any pathognomonic lesions caused by CA. Therefore, it may be concluded that CA
produces no toxicity in Wistar rats.

Keywords : Centella asiatica (L.) Urban, Toxicity

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