Page 31 - วารสารปีที่15ฉบับที่1

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¥—ß· ¥ß„πμ“√“ß∑’Ë 2 æ∫«à“ºßÀ≠â“·Àâß¡’ª√‘¡“≥ ®“°°“√‡º“ æ∫«à“ª√–°Õ∫¥â«¬ “√ phenolic com-

´‘≈‘°“‡∑à“°—∫√âÕ¬≈– 6.15 ‚¥¬æ∫´‘≈‘°“„π “√ °—¥ pounds ‰¥â·°à “√°≈ÿࡉ´√‘ß°Õ≈ (syringols) “√
πÈ”μâ¡ ·≈– “√ °—¥¥â«¬ ethanol 95% ¡’§à“‡∑à“°—∫ °≈ÿࡉ°«Õ–§Õ≈ (guaiacols) “√°≈ÿà¡øïπÕ≈∑’Ë¡’À¡Ÿà
√âÕ¬≈– 3.78 ·≈– 0.16 μ“¡≈”¥—∫ ´÷Ëß· ¥ß„Àâ‡ÀÁπ ·∑π∑’Ëμà“ß Ê (other substituted phenols) ‡ªìπμâπ

«à“´‘≈‘°“ “¡“√∂≈–≈“¬„ππÈ”μâ¡¡“°°«à“·Õ≈°ÕŒÕ≈å “√°≈ÿà¡Õπÿæ—π∏å¢ÕßøïπÕ≈ (phenol derivatives)
ª√‘¡“≥·√à∏“μÿ√«¡„πºßÀ≠â“·Àâß “√ °—¥πÈ”μâ¡ À≈“¬™π‘¥¡’ƒ∑∏‘Ï„π°“√μâ“π‡™◊ÈÕ®ÿ≈™’æ°àÕ‚√§ ‡™àπ “√
·≈– “√ °—¥·Õ≈°ÕŒÕ≈å¡’‡∑à“°—∫√âÕ¬≈– 13.49, 23.42 4-ethylguaiacol ·≈– “√ syringol ¡’ƒ∑∏‘Ïμâ“π‡™◊ÈÕ
[34]
·≈– 22.15 μ“¡≈”¥—∫ à«πª√‘¡“≥´‘≈‘°Õπ (Silicon; √“ Trichophyton mentagrophytes “√ van-
Si) ∑’Ë«‘‡§√“–À剥⡒§à“√âÕ¬≈– 2.89 1.77 ·≈– 0.07 illin ¡’ƒ∑∏‘Ï„π°“√μâ“π‡™◊ÈÕ·∫§∑’‡√’¬ Escherichia

μ“¡≈”¥—∫ ‡¡◊ËÕ‡∑’¬∫°—∫ºß°≈⫬πÈ”«â“·≈–·≈–ºß coli, Pseudomonas aeruginosa, Enterobacter
°≈⫬ÀÕ¡∑’Ë¡’ª√‘¡“≥·√à∏“μÿ√«¡‡∑à“°—∫√âÕ¬≈– 5.75 aerogenes, Salmonella enterica ·≈–μâ“π‡™◊ÈÕ√“
·≈– 9.08 μ“¡≈”¥—∫ ·≈–¡’ª√‘¡“≥´‘≈‘°“‡∑à“°—∫ Candida albicans, Lactobacillus casei, Peni-

√âÕ¬≈– 0.18 ·≈– 0.07 μ“¡≈”¥—∫ ‚¥¬æ∫«à“ºßÀ≠â“ cillium expansum, Saccharomyces cerevisiae
[35]
¬ÿà¡ ºß°≈⫬πÈ”«â“·≈–ºß°≈⫬ÀÕ¡ ¡’‚æ·∑ ‡´’¬¡ ´÷Ëß¡’§à“ MIC „π™à«ß 6-18 mM ƒ∑∏‘Ï„π°“√μâ“π
ª√‘¡“≥√âÕ¬≈– 5.22, 4.09 ·≈– 6.86 μ“¡≈”¥—∫ ‡™◊ÈÕ√“¢Õß vanillin, 4-hydroxybenzaldehyde ·≈–
´‘≈‘°“À√◊Õ silicon dioxide (SiO ) ‡ªìπ “√ª√–°Õ∫ phenol ¡’§à“ MIC 5.7 mM, 9.1 mM ·≈– 10.6
2
√–À«à“ß∏“μÿ´‘≈‘°Õπ·≈–∏“μÿÕÕ°´‘‡®π ´‘≈‘°Õπæ∫ mM μ“¡≈”¥—∫ ‚¥¬æ∫«à“À¡Ÿàøíß°å™—Ëπ∑’Ë¡’ à«π ”§—≠

„π‡π◊ÈÕ‡¬◊ËÕ‡°’ˬ«æ—π °√–¥Ÿ°·≈–º‘«Àπ—ß ‚¥¬·À≈àß „π°“√μâ“π‡™◊ÈÕ√“¢Õß vanillin §◊Õ aldehyde group
[36]
¢Õß´‘≈‘°Õπ∑’Ë√à“ß°“¬‰¥â√—∫®–¡“®“°Õ“À“√·≈–πÈ”¥◊Ë¡ ·≈–À¡Ÿà·∑π∑’Ë∫π benzene ring πÕ°®“°π’Ȭ—ß
ª√–¡“≥«—π≈– 20-50 mg ´‘≈‘°Õπ∑’Ëæ∫„ππÈ”®–Õ¬Ÿà ¡’°“√„™â “√ resorcinol ‡ªìπ à«πº ¡„πº≈‘μ¿—≥±å
[32]
„π√Ÿª ortho-silicic acid (Si(OH )) ¡’°“√»÷°…“ ”À√—∫‚√§º‘«Àπ—ß∫“ß™π‘¥ ‡™àπ acne, seborrhoeic
4
æ∫«à“´‘≈‘°Õπ¡’º≈™à«¬‡æ‘Ë¡§«“¡Àπ“·πàπ¢Õß¡«≈ dermatitis, eczema, psoriasis, corns, ·≈–
[37]
°√–¥Ÿ°·≈–§«“¡·¢Áß·√ߢÕß°√–¥Ÿ°„π —μ«å∑¥≈Õß warts
[33]
·≈–„π§π
¢âÕ √ÿª
°“√»÷°…“Õߧåª√–°Õ∫∑“߇§¡’®“°°“√

«‘‡§√“–Àå¥â«¬ GC-MS æ∫«à“ “√ °—¥ acetone °“√»÷°…“ª√‘¡“≥ “√Õ“À“√®“° à«π‡Àπ◊Õ¥‘π
®“° à«π‡Àπ◊Õ¥‘π¢ÕßÀ≠â“™π‘¥π’Ȫ√–°Õ∫¥â«¬ “√ ¢ÕßÀ≠â“™π‘¥π’È æ∫«à“ª√–°Õ∫¥â«¬‚ª√μ’π „¬Õ“À“√
°≈ÿࡉ¡à¡’¢—È« ‰¥â·°à °√¥‰¢¡—π (fatty acids) “√°≈ÿà¡ °√¥Õ–¡‘‚π «‘μ“¡‘π ·≈–·√à∏“μÿ ‡™àπ ´‘≈‘°Õπ à«π

phytosterols ·≈–«‘μ“¡‘πÕ’ ‡ªìπμâπ πÕ°®“°π’È °“√«‘‡§√“–ÀåÕߧåª√–°Õ∫∑“߇§¡’ æ∫«à“ª√–°Õ∫
¬—ߪ√–°Õ∫¥â«¬ “√∑’ˉ¡à∑√“∫ Ÿμ√‚§√ß √â“ß∑“߇§¡’ ¥â«¬ “√°≈ÿà¡ phenolics [‰¥â·°à 4-coumaric acid]

Õ’°À≈“¬™π‘¥ à«πÕߧåª√–°Õ∫∑“߇§¡’®“°§«—π‰ø “√°≈ÿà¡ flavonoids [‰¥â·°à 5,7,4'-trimethoxyflavone]
∑’ˇ°‘¥®“°°“√‡º“ºßÀ≠â“·Àâß ·≈–§√“∫‡À≈◊Õß∑’ˇ°‘¥ “√°≈ÿà¡°√¥‰¢¡—π (fatty acids) “√°≈ÿà¡ phy-