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Ÿß¢÷Èπ®“°æ◊Èπ¥‘π ´÷Ë߇¡◊ËÕ√«¡°—π√–À«à“ß∑“߇¥‘π∑’Ë·§∫ dihydromethysticin, kavain, dihydrokavain,
[15]
‡ªî¥‚≈àß·≈–¬° Ÿß¢÷Èπ®“°æ◊Èπ ®÷߇ªìπæ◊Èπ∑’Ë∑’Ë —μ«å demethoxyyangonin ·≈– yangonin ®“°°“√
[10,12]
∑¥≈Õß¡—°®–À≈’°‡≈’Ë¬ß »÷°…“æ∫«à“ Kavain ·≈– methysticin ¬—∫¬—Èß°“√
DLB ‡ªìπ·∫∫®”≈Õß√Ÿª·∫∫°“√°√–μÿâπ ∑”ß“π¢Õß voltage-dependent sodium channel
[12,13]
ªØ‘°‘√‘¬“¢Õß —μ«å∑¥≈Õߥ⫬§«“¡ «à“ß ·∫∫ ¢Õ߇´≈≈åª√– “∑∑’Ë·¬°ÕÕ°¡“®“° à«πŒ‘ª‚ª·§¡ªí
[17]
®”≈Õßπ’È¡’≈—°…≥–‡ªìπæ◊Èπ∑’Ë‚≈àß„Àâ —μ«å∑¥≈Õß CA1 „π ¡Õß (in vitro) ·≈–ª°ªÑÕ߇´≈≈å
”√«®‰¥â ´÷Ëߪ√–°Õ∫‰ª¥â«¬ 2 à«π à«π∑’Ë «à“ß ª√– “∑®“°°“√∂Ÿ°∑”≈“¬¥â«¬ lactate ∑’ˉ¥â®“°
[18]
·≈– à«π∑’Ë¡◊¥ Õ—μ√“ à«π 2:1 ·≈–¡’™àÕß∑’Ëμ‘¥μàÕ°—π anaerobic synthesis °“√»÷°…“ aortic ring
√–À«à“ß 2 æ◊Èπ∑’Ë ¥—ß· ¥ß„π√Ÿª∑’Ë 1B —μ«å∑¥≈Õß ∑’Ëμ—¥ÕÕ°¡“®“°μ—«ÀπŸ·√∑ æ∫«à“ Kavain ¬—∫¬—Èß

¡—°®–À≈’°‡≈’ˬßæ◊Èπ∑’Ë‚≈àß·≈– «à“ß °“√À¥μ—«¢Õß aortic ring ∑’Ë∂Ÿ°°√–μÿâπ¥â«¬ “√ phe-
OFT (√Ÿª∑’Ë 1C) ‡ªìπ·∫∫®”≈Õß√Ÿª·∫∫°“√ nylephrine ‚¥¬ÕÕ°ƒ∑∏‘Ϻà“π∑“ß L-type calcium
[19]
°√–μÿâπªØ‘°‘√‘¬“¢Õß —μ«å∑¥≈Õߥ⫬§«“¡°«â“ߢÕß channels Kavain ·≈– desmethoxyyangonin
æ◊Èπ∑’Ë —μ«å∑¥≈Õß®–À≈’°‡≈’ˬß∫√‘‡«≥μ√ß°≈“ߢÕß ‡æ‘Ë¡°“√À≈—ËߢÕß “√ ◊ËÕª√– “∑ dopamine (DA) „π
[9,12,14] [20]
·∫∫®”≈Õß™π‘¥π’È nucleus accumbens ·≈– norepinephrine
„π hippocampus ·≈– cerebral cortex ¢ÕßÀπŸ
4. ¡ÿπ‰æ√∑’Ëπ”¡“„™â√—°…“‚√§«‘μ°°—ß«≈ [21]
·√∑ °“√»÷°…“ in vitro ¥â«¬«‘∏’ radioreceptor
4.1 Piper methysticum (Kava) assay (RRA) ‚¥¬„™â [H3] bicuculline metho-

Kava ™◊ËÕ∑“ß«‘∑¬“»“ μ√å§◊Õ Piper methy- chloride „π membrane suspension æ∫«à“
sticum ®—¥Õ¬Ÿà„πμ√–°Ÿ≈æ√‘°‰∑¬ ¡’ƒ∑∏‘ϧ≈“¬ Yangonin, kavain, dihydrokavain ·≈–
°≈â“¡‡π◊ÈÕ·≈– ß∫Õ“√¡≥å Kava lactones ‡ªìπ dihydromethysticin ‡æ‘Ë¡®”π«π°“√®—∫∑’Ë∫√‘‡«≥

°≈ÿà¡¢Õß “√ ”§—≠∑’ËÕÕ°ƒ∑∏‘ϧ≈“¬°—ß«≈ æ∫‰¥â„π GABA-α [22] °“√»÷°…“ in vivo ∑’Ë∫√‘‡«≥ hippo-
[15]
à«π¢Õß√“°·≈–·ßàß∑’ËÕ¬Ÿà„μâæ◊Èπ¥‘π ∂Ÿ°‡¡μ“∫Õ- campus, amygdala ·≈– medulla oblongata
‰≈´å¥â«¬√–∫∫‰´‚삧√¡æ’ 450 (CYP450) „π æ∫«à“ kava lactones ‡æ‘Ë¡®”π«π°“√®—∫¢Õß “√
[16]
μ—∫ kava lactones ª√–°Õ∫¥â«¬ methysticin, [H3] muscimol °—∫μ—«√—∫∑’Ë∫√‘‡«≥¢Õß ¡Õß à«π

A B C

√Ÿª∑’Ë 1 ·∫∫®”≈Õß∑’Ë„™â„π°“√∑¥ Õ∫ƒ∑∏‘ϧ≈“¬°—ß«≈„π —μ«å∑¥≈Õß A) elevated plus maze, B) Dark/Light box
·≈– C) Open field test.