Page 45 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 14 ฉบับที่ 3

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¥—ß°≈à“«¢ÕßÀπŸ·√∑Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ ·≈– tones 30% (LI 150) 400 mg/day ‡¡◊ËÕºŸâªÉ«¬‰¥â
°“√»÷°…“ in vitro ‚¥¬„™â ¡Õß à«π brain stem √—∫‡ªìπ‡«≈“ 8 —ª¥“Àå ‰¡à àߺ≈„Àâ¡’§«“¡·μ°μà“ß
∫√‘‡«≥ nucleus tractus solitarius ¢ÕßÀπŸ·√∑Õ“¬ÿ °—πÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘°—∫°≈ÿࡺŸâªÉ«¬∑’ˉ¥â√—∫
2-5 «—π æ∫«à“‡¡◊ËÕ„Àâ “√ kavalactones À√◊Õ Buspiron 10 mg/day ·≈– Opipramol 100 mg/
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dihydrokavain °àÕπ„Àâ “√ muscimol “¡“√∂≈¥ day °“√∑¥ Õ∫„πºŸâªÉ«¬∑’Ë«‘π‘®©—¬«à“‡ªìπ GAD
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gastric vagus response ‰¥â ‰¡à‡°‘π 1 ‡¥◊Õπ À√◊Õ‡æ‘Ë߇√‘Ë¡¡’√Õ¬‚√§æ∫«à“ °“√‰¥â
4.1.1 °“√»÷°…“ƒ∑∏‘ϧ≈“¬°—ß«≈„πæƒμ‘°√√¡ √—∫ 250 mg/day aqueous extract ¿“¬„π 3 —ª¥“Àå

¢Õß —μ«å∑¥≈Õߥ⫬ EPM æ∫«à“ “√ °—¥ kava ¥â«¬ “¡“√∂≈¥Õ“°“√«‘μ°°—ß«≈‰¥â®“°°“√ª√–‡¡‘π¥â«¬
96% ethanol (LI 150) “¡“√∂‡æ‘Ë¡‡«≈“∑’ËÀπŸ·√∑ HAMA, Bech Anxiety Inventory (BAI) ·≈–

Õ¬Ÿà„π à«π‡ªî¥ ·≈–‡æ‘Ë¡®”π«π√âÕ¬≈–¢Õß°“√‡¢â“‰ª Montgomery-Asberg Depression Rating Scale
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∑’Ë à«π‡ªî¥¡“°¢÷ÈπÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘쑇¡◊ËÕ (MADRS) „π¢≥–∑’Ë°“√‡æ‘Ë¡ª√‘¡“≥ “√ °—¥
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‡ª√’¬∫‡∑’¬∫°—∫°≈ÿࡧ«∫§ÿ¡ kava lactones ®“° 149 mg/day ‰ª‡ªìπ 280 mg/
4.1.2 °“√»÷°…“ƒ∑∏‘ϧ≈“¬°—ß«≈∑“ß day „π‡«≈“ 4 —ª¥“Àå ‰¡à¡’º≈·μ°μà“ßÕ¬à“ß¡’
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§≈‘π‘° π—¬ ”§—≠ °“√»÷°…“„π°≈ÿà¡¢ÕߺŸâªÉ«¬ neurotic
°“√∑¥ Õ∫„π°≈ÿà¡¢ÕßÕ“ “ ¡—§√ª°μ‘∑’Ë anxiety æ∫«à“ 150 mg/day ¢Õß kava special
‰¡à‡ªìπ‚√§«‘μ°°—ß«≈∑’ˉ¥â√—∫ “√ °—¥ kava 70 mg extract WS 1490 ‡ªìπ‡«≈“ 4 —ª¥“Àå ¡’º≈≈¥
‡ªìπ‡«≈“ 24 —ª¥“Àå “¡“√∂≈¥Õ“°“√«‘μ°°—ß«≈ §«“¡«‘μ°°—ß«≈‡¡◊ËÕ„™â°“√ª√–‡¡‘π¥â«¬ Anxiety

‚¥¬«—¥®“° Hamilton Anxiety Scale (HAMA), Sensitivity Index (ASI) ·μà‰¡à¡’§«“¡·μ°μà“ß
Clinical Global Impression (CGI), Self-Report Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘쑇¡◊ËÕ‡ª√’¬∫‡∑’¬∫°—∫°≈ÿà¡
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Symptom Inventory-90 items revised Anxie- §«∫§ÿ¡ „π¢≥–∑’Ë°“√„™â 100 mg/day (30%
ty (SCL-90-R-ANX) ·≈– Adjective Mood Scale kava lactones) √à«¡°—∫ 6.4 mg/day valerian
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(AMS) ·≈–Õ“ “ ¡—§√ª°μ‘∑’ˉ¥â√—∫ benzodia- ‡ªìπ‡«≈“ 28 «—π ¡’º≈≈¥§«“¡«‘μ°°—ß«≈®“°°“√
zepines °àÕπ‡ªìπ‡«≈“ 2 —ª¥“Àå ·≈–μ“¡¥â«¬ “√ ª√–‡¡‘π¥â«¬ State-Trait Anxiety Inventory

°—¥™π‘¥¥—ß°≈à“« 35 mg Õ’° 3 —ª¥“Àå “¡“√∂ (STAI) ·μଗߧ߉¡à¡’§«“¡·μ°μà“ßÕ¬à“ß¡’π—¬ ”§—≠
≈¥Õ“°“√· ¥ßÕÕ°∑“ߧ«“¡«‘μ°°—ß«≈‰¥â‚¥¬¥Ÿ®“° „π°≈ÿࡺŸâªÉ«¬‚√§πÕπ‰¡àÀ≈—∫√à«¡°—∫‡°‘¥§«“¡«‘μ°
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º≈ HAMA, CGI, Subjective well-being score °—ß«≈ °“√»÷°…“„πºŸâªÉ«¬∑’ˇªìπ‚√§´÷¡‡»√â“Õ¬à“ß
(Bf-s) ·≈– Erlanger Anxiety, Tension and √ÿπ·√ß√à«¡°—∫°“√‡°‘¥§«“¡«‘μ°°—ß«≈ æ∫«à“ “√
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Aggression Scale (EAAS) ºŸâªÉ«¬°≈ÿà¡ GAD °—¥À¬“∫¥â«¬πÈ”¢Õß kava ª√‘¡“≥ 1.8-2.66 g/day
‰¥â√—∫ 30% standardized kavalactones 280 mg/ ‡ªìπ‡«≈“ 4 —ª¥“Àå ‰¡à “¡“√∂≈¥§«“¡«‘μ°°—ß«≈
day ‡ªìπ‡«≈“ 4 —ª¥“Àå “¡“√∂≈¥®—ßÀ«–°“√‡μâπ ≈߉¥â ‡¡◊ËÕª√–‡¡‘π¥â«¬ Beck Depression Inven-
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¢ÕßÀ—«„®„πºŸâªÉ«¬ panic ∑’Ë∂Ÿ°∑”„À⇰‘¥§«“¡μ◊Ëπ tory II (BDI-II)
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μ√–Àπ°‰¥â ¢≥–∑’Ë “√ °—¥¡“μ√∞“π kava lac- 4.1.3 Õ“°“√¢â“߇§’¬ß §«“¡‡ªìπæ‘… ·≈–