Page 47 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 14 ฉบับที่ 3

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∫√‘‡«≥°√–¥Ÿ° —πÀ≈—ß æ∫«à“ “√ °—¥ passion oxide
flower ¥â«¬πÈ” 140 mg/ml ≈¥§«“¡«‘μ°°—ß«≈‰¥â 4.3.1 °“√»÷°…“ƒ∑∏‘ϧ≈“¬°—ß«≈∫π EPM
®“°°“√ª√–‡¡‘π State Anxiety Inventory æ∫«à“ Lyophilized aqueous extracts 5 mg/kg
[44] [52]
(SAI) „πºŸâªÉ«¬ GAD ∑’ˉ¥â√—∫ “√ °—¥ 5 À¬¥ ‡æ‘Ë¡‡«≈“·≈–°“√‡¢â“ Ÿà à«π‡ªî¥¢ÕßÀπŸ‡¡“ å “√
μàÕ«—𠇪ìπ‡«≈“ 4 —ª¥“Àå · ¥ß°“√≈¥≈ߢÕß °—¥¡“μ√∞“π 50% ethanol „πª√‘¡“≥ 100 ·≈–
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§«“¡«‘μ°°—ß«≈¥â«¬°“√ª√–‡¡‘π HAMA 200 mg/kg ∑’Ë„Àâ∑“ߪ“°‡ªìπ‡«≈“ 3 «—πμ‘¥μàÕ°—π
4.2.3 Õ“°“√¢â“߇§’¬ß §«“¡‡ªìπæ‘… ·≈– ‡æ‘Ë¡‡«≈“·≈–°“√‡¢â“ Ÿà à«π‡ªî¥¢ÕßÀπŸ·√∑‡¡◊ËÕ
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§«“¡ª≈Õ¥¿—¬„π°“√„™â ‡ª√’¬∫‡∑’¬∫°—∫°≈ÿࡧ«∫§ÿ¡ º≈°“√»÷°…“„π
‰¡àæ∫§«“¡‡ªìπæ‘…‡©’¬∫æ≈—π¢Õß “√ °—¥ DLB “√ °—¥À¬“∫¢π“¥ 1.8 g/kg ¡’ƒ∑∏‘ϧ≈“¬
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900 mg/kg ‡¡◊ËÕ„Àâ∑“ߪ“°„πÀπŸ‡¡“ å “√ °—¥ °—ß«≈„πÀπŸ·√∑ ‚¥¬‡æ‘Ë¡‡«≈“‡√‘Ë¡μâπ‡¥‘π‡¢â“ Ÿà à«π
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¥â«¬‡¡∑“πÕ≈∑’˪√‘¡“≥ 50-1,600 mg/kg ‡«≈“ 7 ¡◊¥„Àâπ“π¢÷Èπ º≈°“√»÷°…“„π OFT æ∫ “√ °—¥
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«—π ‰¡à∑”„ÀâÀπŸ‡¡“ å쓬 ‰¡à¡’√“¬ß“π°“√„™â “√ ¡“μ√∞“π 50% ethanol „πª√‘¡“≥ 100 ·≈– 200
°—¥™π‘¥π’ȇ°‘π¢π“¥„π§π πÕ°®“°π’È passion mg/kg ∑’Ë„Àâ∑“ߪ“°‡ªìπ‡«≈“ 3 «—πμ‘¥μàÕ°—π ‡æ‘Ë¡
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flower Õ“®®–‡æ‘Ë¡°“√À¥μ—«¢Õß¡¥≈Ÿ° ®÷߇ªìπ¢âÕ ‡«≈“∑’ËÀπŸ·√∑«‘Ë߇¢â“ Ÿà à«π°≈“ߢÕß OFT πÕ°®“°
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Àâ“¡ ”À√—∫ μ√’¡’§√√¿å π’È “√ °—¥¡“μ√∞“π∑’Ë„Àâ∑“ߪ“° 150 ·≈– 300 mg/
4.3 Hypericum perforatum (St Johnûs kg ≈¥‡«≈“„π°“√À¬ÿ¥π‘ËߢÕß°“√∑¥ Õ∫¥â«¬ force
wort) swim test ·≈–‡¡◊ËÕ„Àâ “√ °—¥¥—ß°≈à“«‡ªìπ‡«≈“

St Johnûs wort ‰¥â¡“®“°¥Õ°‰¡â¢Õßæ◊™¬◊πμâπ 7 «—πμ‘¥μàÕ°—π ÀπŸ·√∑· ¥ß°“√‡¢â“ Ÿà à«π∑’˧«√
‡ªìπ ¡ÿπ‰æ√·ºπ‚∫√“≥∑’Ë„™â°—πÕ¬à“ß·æ√àÀ≈“¬ ‰¥â À≈’°‡≈’ˬ߇æ‘Ë¡¢÷Èπ (escape avoidance) „π°“√∑¥ Õ∫
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√—∫°“√√—∫√Õß„πª√–‡∑»‡¬Õ√¡π’‡æ◊ËÕ„™â„π°“√√—°…“ ¥â«¬ elevated T maze
‚√§«‘μ°°—ß«≈ ‚√§´÷¡‡»√â“ ·≈–‚√§πÕπ‰¡àÀ≈—∫ 4.3.2 °“√»÷°…“ƒ∑∏‘ϧ≈“¬°—ß«≈∑“ß
“√ÕÕ°ƒ∑∏‘Ï ”§—≠ª√–°Õ∫¥â«¬ hyperforin, hy- §≈‘π‘°
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pericin ·≈– pseudohypericin ®“°°“√»÷°…“ ºŸâªÉ«¬ OCD 12 √“¬ ‰¥â√—∫°“√√—°…“¥â«¬
„πμ—∫À¡Ÿ æ∫«à“ “√ °—¥À¬“∫ ·≈– hypericin St Johnûs wort ª√‘¡“≥ 300-1,800 mg/day «—π
“¡“√∂¬—∫¬—Èß°“√∑”ß“π¢Õß monoamine oxidase ≈– 2 §√—Èßμ‘¥μàÕ°—π‡ªìπ‡«≈“ 12 —ª¥“Àå ¡’Õ“°“√¥’
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(MAO) ‰¥â °“√»÷°…“‚¥¬„™â RRA æ∫«à“ ¢÷Èπ®“°°“√ª√–‡¡‘π¥â«¬ Yale-Brown Obsessive
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hydromethalic extract “¡“√∂®—∫°—∫μ—«√—∫ Compulsive Scale (Y-BOCS) „π¢≥–∑’Ëπ—°«‘®—¬
GABAA ·≈– DA transporter ‰¥â ∑’Ë IC50 5.5 Õ’°°≈ÿà¡æ∫«à“ ºŸâªÉ«¬∑’ˇæ‘Ëß∂Ÿ°«‘π‘®©—¬«à“‡ªìπ OCD

μg/ml ·≈– 24.5 μg/ml μ“¡≈”¥—∫ à«π lipophilic ‰¡à‡°‘π 1 ªï ®”π«π 16 √“¬ ‰¥â√—∫ St Johnûs wort
extract ÕÕ°ƒ∑∏‘Ϻà“π∑“ß DA transporter ‚¥¬¡’ „π¢π“¥ 600-1,800 ¡‘≈≈‘°√—¡ ‡ªìπ‡«≈“ 12 —ª¥“Àå
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§à“ IC50 ‡∑à“°—∫ 12.9 μg/ml πÕ°®“°π’È°“√»÷°…“ °“√ª√–‡¡‘π¥â«¬ Y-BOCS ¡’§à“≈¥≈ß„π°≈ÿࡺŸâªÉ«¬
„π√°¢Õß§π ¬—ßæ∫º≈ƒ∑∏‘Ϭ—∫¬—Èß°“√º≈‘μ “√ super- ·μà‰¡à·μ°μà“ß°—πÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘쑇¡◊ËÕ