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Journal of Thai Traditional & Alternative Medicine Vol. 5 No. 3 September-December 2007
Vol. 5 No. 3 September - December 2007
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Original Article

The Efficacy of Andrographis paniculata

(Burm. f.) Wall. ex Nees for the Relief of the

Symptoms of Influenza

Anchalee Chuthaputti*
†
Virul Pornpatkul
‡
Udomlug Suwankiri

Abstract
Tablets or capsules of the dried aerial part of Andrographis paniculata (Burm.f.) Wall. ex Nees comprise
a single herbal medicine selected for inclusion in the National List of Essential Drugs in Thailand for the relief
of the symptoms of the common cold; however, there is no clinical evidence yet to support its similar use for
influenza. Therefore, this study was conducted to determine if A. paniculata could also relieve the symptoms
of influenza as it does in the common cold. A multi-center, randomized controlled open-label study was car-
ried out in health-service centers and a hospital under the Nonthaburi Provincial Public Health Office in
patients having a fever of 38˚C or higher, respiratory and constitutional symptoms for no longer than 36
hours, and laboratory-confirmed as having influenza. Patients were randomly divided into two groups: Group
I received paracetamol tablets at the dose of 1 gram every 6 hours for fever, headache and myalgia; and Group
II received the same dose of paracetamol and A. paniculata capsules at the dose of 1.6 grams 4 times daily.
Body temperatures were recorded and the severity of the symptoms of influenza, namely nasal congestion/
runny nose, sore throat, cough, headache, malaise, myalgia, fatigue, chill, and overall symptoms were deter-
mined by the Visual Analog Scale on the day of enrollment (Day 0) and on Days 2, 4 and 6 of the treatment. At
the end of the study there were 10 patients in Group I and 15 patients in the Group II. It was found that in
Group II, from Day 2 of the treatment, body temperature, the severity of overall symptoms and almost all the
other symptoms of influenza, except for cough, were significantly improved compared with those of Day 0.
Meanwhile, for Group I, on Day 2 only the body temperature, overall symptoms and malaise were signifi-
cantly lower than the values on Day 0. When comparing the two groups, it was found that the severity of
cough, fatigue, and overall symptoms of the group treated with paracetamol and A. paniculata was signifi-
cantly lower than that of the group treated with paracetamol alone from Day 4 of the treatment. Eighty
percent of the patients in Group II would choose the same medications again the next time they have influ-
enza, while only 20 percent of the patients in Group I would do so. The numbers of patients who would choose
the previously prescribed medications or new medication were statistically significantly different between the
two groups. In conclusion, the present study showed that Andrographis paniculata, when given together with
paracetamol, could significantly reduce the severity of the overall symptoms of influenza and induce a more
rapid improvement of various symptoms of influenza better than paracetamol alone did. This finding war-
rants a recommendation for using Andrographis paniculata for influenza in primary health care and inclusion
on the National List of Essential Drugs as well as further study in a larger group of patients in the future.
Key words: Andrographis paniculata, influenza, symptom

*Institute of Thai Traditional Medicine, Department for the Development of Thai Traditional and Alternative Medicine
†
Narathiwat Rajanakarin Hospital, Narathiwat province
‡
Nonthaburi Provincial Public Health Office

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