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«“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬å∑“߇≈◊Õ°              ªï∑’Ë Ù ©∫—∫∑’Ë Ú °ÿ¡¿“æ—π∏å -情¿“§¡ ÚıÙ˘ 31



                      √Õ¥◊Ë¡¢≥–ÕÿàπÊ °≈ÿà¡ G2 ®–‰¥â√—∫°“√Ωñ°„Àâµ√«® pH ‡æ◊ËÕª√—∫ª√‘¡“≥¬“°àÕπº ¡ SPC ≈–≈“¬πÈ”
                      ·≈–¥◊Ë¡ 3 ‡«≈“À≈—ßÕ“À“√ ‡æ◊ËÕ√—°…“√–¥—∫ pH ¢Õßªí  “«–Õ¬Ÿà√–À«à“ß 6.2-6.8 „π√“¬∑’˵√«®æ∫«à“

                      ¡’‡¡Á¥‡≈◊Õ¥¢“«„πªí  “«–µ—Èß·µàÀ√◊Õ‡∑à“°—∫ +1 ¢÷Èπ‰ª ®–‰¥â√—∫¬“ªØ‘™’«π–‡ªìπ‡«≈“ 2 ‡¥◊Õπ ·µà∂⓬—ß
                      µ√«®æ∫‡¡Á¥‡≈◊Õ¥¢“«„πªí  “«–µàÕÕ’°°Á®–‰¥â√—∫¬“ªØ‘™’«π–„π¢π“¥µË”‡æ◊ËÕ§«∫§ÿ¡‡™◊ÈÕµ≈Õ¥°“√»÷°…“
                               °“√µ√«®∑“ßÀâÕߪؑ∫—µ‘°“√ ªí  “«–∑’ˇ°Á∫¡“®–‰¥â√—∫°“√µ√«®À“ serum creatinine
                      ‚¥¬«‘∏’¢Õß·®ø‡ø (Jaffeûs reaction), µ√«®À“calcium ‚¥¬«‘∏’  atomic absorption spectropho-

                      tometer, potassium ·≈– sodium ‚¥¬  flame photometry,  uric acid ‚¥¬«‘∏’ uricase, oxalate
                      ‚¥¬«‘∏’°“√¢Õß»√’∫ÿ≠≈◊Õ 9



                      °“√§”π«≥À“Õ—µ√“°“√≈¥¢π“¥¢Õßπ‘Ë«‰µ
                               ¢π“¥¢Õßπ‘Ë«‰µ°“√∑”Õÿ≈µ√“´“«¥å·µà≈–§√—Èß®–∂Ÿ°∫—π∑÷°‰«â„π«’¥’‚Õ‡∑ª Õà“πº≈‚¥¬
                      ºŸâµ√«® Õ∫Õ¬à“ßπâÕ¬ 3 ∑à“π ‚¥¬∑à“πÀπ÷Ë߇ªìπ√—ß ’·æ∑¬å  ´÷Ëß·µà≈–§π®–‰¡à√Ÿâ«à“ºŸâªÉ«¬π—ÈπÕ¬Ÿà°≈ÿࡉÀπ

                               ¢π“¥‡ âπºà“»Ÿπ¬å°≈“ߢÕßπ‘Ë«„π™à«ß°àÕπ√—∫¬“·≈–À≈—ß ‘Èπ ÿ¥°“√√—°…“µ“¡‚§√ß°“√®–
                      ∂Ÿ°π”¡“§”π«≥µ“¡ Ÿµ√¢â“ß≈à“ß °“√§”π«≥Õ—µ√“°“√≈¥¢π“¥¢Õßπ‘Ë«‰µ§‘¥‡ªìπ√âÕ¬≈–µàÕªï (Rate of
                      size reduction per year, ROSRPY) π—Èπ„™â Ÿµ√¥—ßµàÕ‰ªπ’È

                                  ROSRPY (%)=52x (size wk 0-size wk N)x100 (%)
                                                        N x size wk 0


                                                N = √–¬–‡«≈“‡ªìπ —ª¥“Àå¢Õß°“√√—°…“

                                       Size wk 0 = §«“¡¬“«¢Õ߇ âπºà“»Ÿπ¬å°≈“ß (mm.) ∑’Ë°àÕπ√—°…“
                                       Size wk N = §«“¡¬“«¢Õ߇ âπºà“»Ÿπ¬å°≈“ß (mm.) ≥  —ª¥“Àå∑’Ë N
                                ∂‘µ‘∑’Ë„™â„π°“√«‘‡§√“–À凪√’¬∫‡∑’¬∫√–À«à“ß°≈ÿà¡ °√≥’ Continuous data À“°¡’°“√

                      °√–®“¬¢ÕߢâÕ¡Ÿ≈·∫∫ª°µ‘ t-test À“°°“√°√–®“¬‰¡àª°µ‘„™â Mann-Whitney U À√◊Õ Kruskal
                      Wallis Test ¢÷Èπ°—∫®”π«π°≈ÿà¡ °√≥’∑’ˇªìπ Categorical data „™â Chi square test À√◊Õ Fisher
                      exact test



                      º≈¢Õß°“√»÷°…“
                               °“√¢“¥À“¬‰ª ‚¥¬ºŸâ‡¢â“√à«¡°“√»÷°…“∑’Ë¢“¥‰ª 7 √“¬ Õ¬Ÿà„π°≈ÿà¡ G1 ®”π«π 2 √“¬

                      ·≈–Õ¬Ÿà„π°≈ÿà¡ G2 ®”π«π 5 √“¬ „π°≈ÿà¡ G1 ∑—Èß Õß√“¬ ‡ πÕ«à“µπ‡Õ߉¡àÕ¬“°‡¢â“√à«¡‡æ√“–
                      §‘¥«à“µπ‡Õ߉¡à¡’ªí≠À“  à«π°≈ÿà¡ G2 ÕÕ°®“°°“√»÷°…“‚¥¬·®âß«à“ÕàÕπ‡æ≈’¬ ·≈–‡∫◊ËÕÕ“À“√¡“°®÷ß
                      ¢ÕÕÕ°®“°°“√»÷°…“ °≈ÿà¡ G1 ¡’ºŸâªÉ«¬ 22 √“¬ ‚¥¬¡’°âÕππ‘Ë«®”π«π 33 °âÕπ ·≈–°≈ÿà¡ G2 ¡’ 19 √“¬
                      ¡’π‘Ë«‰µ®”π«π 25 °âÕπ „π°“√»÷°…“π’È®–‰¡àπ”‡Õ“æ«°∑’ËÕÕ°®“°°“√»÷°…“¡“§‘¥‡π◊ËÕß®“°‰¡à “¡“√∂
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