Page 114 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 3 ฉบับที่ 3

112 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë Û ©∫—∫∑’Ë Û ¡‘∂ÿπ“¬π -°—𬓬π ÚıÙ¯

µ“√“ß∑’Ë 8 º≈°“√µ√«®Õ«—¬«–∑“ß®ÿ≈欓∏‘«‘∑¬“¢ÕßÀπŸ·√∑‡æ»‡¡’¬∑’ˉ¥â√—∫ “√ °—¥‡¡≈Á¥§”· ¥

‡ªìπ‡«≈“ 28 «—π

Dose of Bixa orellana extract (mg/kg /day)

Organs Microscopic control 0.24 2.4 12 60

findings n = 15 n = 15 n = 15 n = 15 n = 15

Lung Lymphoid 3/15 6/15 5/15 11/15 10/15
proliferated

bronchioles
Liver Hepatocyte fatty 0/15 0/15 1/15 0/15 2/15
degeneration

Kidney Congestion (mild) 0/15 0/15 7/15* 1/15 0/15
Spleen NRL
Pancreas Acinar hyperplasia 0/15 0/15 0/15 0/15 1/15

Small GALT 1/15 1/15 2/15 4/15 1/15
intestine proliferation
Large GALT 3/15 2/15 3/15 1/15 3/15

intestine proliferation

*·µ°µà“ß®“°°≈ÿࡧ«∫§ÿ¡Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘µ‘ (p<0.05)

º≈°“√µ√«®· ¥ß„π√Ÿª¢Õß ®”π«πÀπŸ∑’Ëæ∫°“√‡ª≈’ˬπ·ª≈ß/®”π«πÀπŸ∑’˵√«®.
GALT=Gut associated lymphoid tissue