Page 41 - วารสารการแพทย์แผนไทย ปีที่ 21 ฉบับที่ 2

J Thai Trad Alt Med Vol. 21 No. 2 May-Aug 2023 257

Table 3 Comparative results of sensory symptoms assessment using The Neuropathy Total Symptom Score-6
(NTSS-6) between SHT remedy and placebo groups

Score NTSS-6 SHT remedy (n = 31) Placebo (n = 31) Mean difference p - value
Mean ± SD Mean ± SD (95%CI)

The total score of the six sensory symptoms
Day 0 10.17 ± 2.22 9.31 ± 3.26 0.86 (-0.56, 2.28) 0.229
Day 14 7.55 ± 2.25 8.59 ± 2.36 -1.04 (-2.21, 0.13) 0.081
a
Day 28 6.30 ± 2.09 8.13 ± 2.50 -1.83 (-3.00, -0.66) 0.003*
a
Change score analysisb -1.92 (-2.21, -1.62) -0.61 (-0.91, -0.32) -1.24 (-1.83, -0.64) < 0.001*
Aching pain
Day 0 2.15 ± 1.08 2.34 ± 0.40 -0.19 (-0.61, 0.23) 0.358
a
Day 14 1.31 ± 0.82 2.33 ± 0.54 -1.02 (-1.38, -0.66) < 0.001*
Day 28 0.96 ± 0.52 2.28 ± 0.61 -1.32 (-1.61, -1.03) < 0.001*
a
Change score analysis -0.62 (-0.71, -0.54) -0.01 (-0.09, 0.08) -0.69 (-0.85, -0.53) < 0.001*
b
Allodynia
Day 0 1.56 ± 0.78 1.29 ± 0.97 0.27 (-0.18, 0.72) 0.234
a
Day 14 1.23 ± 0.80 1.20 ± 0.99 0.02 (-0.44, 0.48) 0.925
Day 28 1.18 ± 0.83 0.98 ± 0.84 0.20 (-0.22, 0.63) 0.339
a
Change score analysis -0.19 (-0.28, -0.1) -0.16 (-0.25, -0.06) -0.03 (-0.21, 0.15) 0.719
b
Burning sensation
Day 0 0.78 ± 1.10 0.31 ± 0.69 0.47 (0.01, 0.94) 0.048*
Day 14 0.63 ± 1.05 0.30 ± 0.67 0.33 (-0.12, 0.78) 0.144
a
Day 28 0.67 ± 1.08 0.33 ± 0.77 0.33 (-0.15, 0.81) 0.169
a
Change score analysis -0.06 (-0.12, 0) 0.01 (-0.05, 0.07) -0.05 (-0.2, 0.09) 0.478
b
Stabbing pain
Day 0 1.63 ± 1.12 1.41 ± 1.22 0.23 (-0.37, 0.82) 0.449
Day 14 1.27 ± 0.94 1.28 ± 1.15 -0.01 (-0.54, 0.52) 0.968
a
Day 28 1.02 ± 0.83 1.1 ± 1.02 -0.08 (-0.55, 0.4) 0.752
a
b
Change score analysis -0.30 (-0.39, -0.22) -0.16 (-0.24, -0.08) -0.13 (-0.29, 0.02) 0.088
Numbness
Day 0 2.75 ± 0.41 2.53 ± 0.33 0.22 (0.03, 0.40) 0.026*
a
Day 14 1.89 ± 0.50 2.44 ± 0.42 -0.55 (-0.78, -0.31) < 0.001*
Day 28 1.32 ± 0.34 2.36 ± 0.52 -1.04 (-1.26, -0.82) < 0.001*
a
b
Change score analysis -0.71 (-0.77, -0.65) -0.09 (-0.15, -0.03) -0.62 (-0.76, -0.48) < 0.001*
Tingling sensation
Day 0 1.48 ± 0.81 1.12 ± 0.88 0.37 (-0.07, 0.80) 0.095
Day 14 1.26 ± 0.80 1.05 ± 0.85 0.20 (-0.22, 0.62) 0.336
a
Day 28 1.15 ± 0.73 1.02 ± 0.87 0.13 (-0.28, 0.54) 0.531
a
Change score analysis -0.16 (-0.23, -0.09) -0.06 (-0.13, 0.02) -0.08 (-0.22, 0.06) 0.248
b
*
b
a Independent t-test generalized estimating equation (GEE) Statistical significance p < 0.05