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J Thai Trad Alt Med Vol. 20 No. 2 May-Aug 2022 233
The median time JGS and DFS—both of about the usage of JG. Further studies on JG,
which have COX2 inhibitory effects—reduc- however, need to be done in a larger scale
ing the swelling was 3 days. The efficacy of population, and MRI is supposed to be em-
4% diclofenac spray, compared to a placebo, ployed to confirm the pharmacological effect
indicated that the pain relief can become sig- of JG.
nificant after 3-4 days [13-14] . Similar result was
observed in our study. Acknowledgement
Serious adverse effects on the subjects We want to express our gratitude to the
in this study were not closely observed by the Chao Phya Abhaibhubejhr hospital foundation
subjects themselves; merely 6.38% patients in for the Justicia gendarussa Burm.f. medicated
the DFS treatment group and 8.3% in the JGS spray, and topical diclofenac spray was pro-
treatment group reported common skin irrita- vided for this research. This research was
tion. The finding of this study was consistent funding by the Chao Phya Abhaibhubejhr
with the earlier study’s finding; approximately hospital foundation.
[15]
5% of the test group reported the side effect
of topical NSAID applied on the patients’ skin. References
One of the limitations on verifying the efficacy 1. Kuehl KS. Review of the efficacy and tolerability of the
diclofenac epolamine topical patch 1.3% in patients
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supposed to be completed before and after the 4. Hu JQ, Deng YF, Daniel TF. 24. JUSTICIA Linnaeus, Sp.
Pl. 1: 15. 1753. Fl. China. 19:449–61. Available from: http://
intervention to confirm the anti-inflammatory flora.huh.harvard.edu/china/PDF/PDF19/Justicia.pdf
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Antinociceptive activity and toxicological study of
The efficacy and safety of using JGS to aqueous leaf extract of Justicia gendarussa Burm.f. in
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not inferior to DFS. This study’s findings were
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