Page 35 - วารสารการแพทย์แผนไทย ปีที่ 20 ฉบับที่ 2 พฤษภาคม-สิงหาคม 2565

J Thai Trad Alt Med Vol. 20 No. 2 May-Aug 2022 233

The median time JGS and DFS—both of about the usage of JG. Further studies on JG,
which have COX2 inhibitory effects—reduc- however, need to be done in a larger scale

ing the swelling was 3 days. The efficacy of population, and MRI is supposed to be em-
4% diclofenac spray, compared to a placebo, ployed to confirm the pharmacological effect
indicated that the pain relief can become sig- of JG.

nificant after 3-4 days [13-14] . Similar result was
observed in our study. Acknowledgement
Serious adverse effects on the subjects We want to express our gratitude to the

in this study were not closely observed by the Chao Phya Abhaibhubejhr hospital foundation
subjects themselves; merely 6.38% patients in for the Justicia gendarussa Burm.f. medicated
the DFS treatment group and 8.3% in the JGS spray, and topical diclofenac spray was pro-

treatment group reported common skin irrita- vided for this research. This research was
tion. The finding of this study was consistent funding by the Chao Phya Abhaibhubejhr

with the earlier study’s finding; approximately hospital foundation.
[15]
5% of the test group reported the side effect
of topical NSAID applied on the patients’ skin. References

One of the limitations on verifying the efficacy 1. Kuehl KS. Review of the efficacy and tolerability of the
diclofenac epolamine topical patch 1.3% in patients
of JGS in this clinical study was the small size with acute pain due to soft tissue injuries. Clin Ther.

of samples. Long-term trials of JGS will pos- 2010;32(6):1001-14.
2. McGriff-Lee N. Management of acute soft tissue injuries.
sibly provide a beneficial information about J Pharm Prac. 2003;16(1):51-8.
the efficacy and safety of topical therapy. 3. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay

Additionally, magnetic resonance imaging HJ. Quantitative systematic review of topically applied
non-steroidal anti-inflammatory drugs. BMJ (Clinical
(MRI) scans and physical examinations are research ed). 1998;316(7128):333-8.
supposed to be completed before and after the 4. Hu JQ, Deng YF, Daniel TF. 24. JUSTICIA Linnaeus, Sp.
Pl. 1: 15. 1753. Fl. China. 19:449–61. Available from: http://
intervention to confirm the anti-inflammatory flora.huh.harvard.edu/china/PDF/PDF19/Justicia.pdf
effect of JG extract. 5. Areekul S. Knowledge of wild plants used in the north-
ern part of Thailand. Volume 2. Bangkok: Royal Project
Foundation. 2009.
Conclusion 6. Ratnasooriya W, Deraniyagala S, Dehigaspitiya D.
Antinociceptive activity and toxicological study of
The efficacy and safety of using JGS to aqueous leaf extract of Justicia gendarussa Burm.f. in

treat mild to moderate tissue injuries were rats. Pharmacogn Mag. 2007;3(11):145-55.
7. Kavitha SK, Viji V, Kripa K, Helen A. Protective effect
not inferior to DFS. This study’s findings were
of Justicia gendarussa Burm.f. on carrageenan-induced
likely to support the traditional knowledge inflammation. J Nat Med. 2011;65(3-4):471-9.