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14  «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ°            ªï∑’Ë Ú ©∫—∫∑’Ë Ú °ÿ¡¿“æ—π∏å-情¿“§¡ ÚıÙ˜



            µ“√“ß∑’ 6 º≈°“√µ√«®§à“∑“߇§¡’§≈‘π‘°¢ÕßÀπŸ¢“«·√∑‡æ»‡¡’¬∑’ˉ¥â√—∫ºß°√–™“¬¥”‡ªìπ‡«≈“ 6 ‡¥◊Õπ
                                              °≈ÿà¡ÀπŸ∑’ˉ¥â√—∫ºß°√–™“¬¥” (¡°./°°./«—π)
                             0          20         200        1000       2000       2000-R
                            n=15       n=15        n=15       n=15       n=15        n=15
             AST (U/L)    89.20±14.54  85.67±19.25  81.93±12.74  85.67±25.09  84.80±20.55  70.47±9.66
             ALT (U/L)    25.07±5.80  27.80±12.84  29.27±8.22  27.67±9.85  26.40±8.55  26.00±6.38
             ALP (U/L)    26.53±6.28  21.67±4.84  23.13.±4.47  23.73±9.31  23.00±5.33  20.40±6.14
             Total protein (g%)  6.84±0.23  6.94±0.24  6.89±0.31  6.97±0.47  7.08±0.32  6.89±0.31
             Albumin (g%)  4.92±0.22  4.98±0.16  5.02±0.22   5.03±0.34  5.07±0.21  4.96±0.22
             Globulin (g%)  1.91±0.26  1.96±0.12  1.87±0.19  1.94±0.27  2.01±0.24  1.93±0.16
             Bilirbuin (mg/dl)  0.097±0.037  0.093±0.030  0.090±0.044  0.091±0.025  0.096±0.037  0.131±0.026*
             BUN (mg%)    22.91±3.33  22.89±4.33  22.571±4.50  21.86±4.80  25.03±6.51  20.54±3.01
             Creatinine (mg%)  0.86±0.09  0.86±0.13  0.81±0.12  0.75±0.09  0.81±0.11  0.79±0.10
             Glucose (mg/dl)  128.56±24.34  131.47±14.87  130.45±15.76  133.60±18.29  132.16±20.44  135.71±17.73
             Uric acid (g%)  1.45±0.64  1.06±0.23  1.05±0.37  1.01±0.65  1.10±0.58  0.72±0.23*
             Triglyceride (mg/dl)  47.53±11.55  53.99±26.07  50.59±17.39  64.31±56.72  56.40±25.25  55.64±15.04
             Cholesterol (mg/dl)  48.83±13.92  51.85±13.88  53.84±12.36  68.60±19.61  78.30±22.36*  65.48±23.92
             Sodium (mmol/l)  148.40±1.30  149.20±1.61  149.33±1.18  149.73±0.96  150.73±1.10*  149.33±1.18
             Potassium (mmol/l)  5.22±1.17  4.34±0.45  4.49±0.99  4.43±0.91  4.17±0.63  4.37±0.41
             Chloride (mmol/l)  112.20±1.01  112.93±1.33  112.87±1.41  112.47±1.73  112.60±2.03  112.33±1.23
             §à“„πµ“√“ß· ¥ß„π√Ÿª§à“‡©≈’ˬ± à«π‡∫’ˬ߇∫π¡“µ√∞“π
             *·µ°µà“ß®“°°≈ÿࡧ«∫§ÿ¡Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘µ‘ (p<0.05)





            µ“√“ß∑’Ë 7 º≈°“√µ√«®‡π◊ÈÕ‡¬◊ËÕÕ«—¬«–∑“ß®ÿ≈欓∏‘«‘∑¬“¢ÕßÀπŸ·√∑‡æ»ºŸâ∑’ˉ¥â√—∫°√–™“¬¥”‡ªìπ‡«≈“ 6 ‡¥◊Õπ
                                                       ¢π“¥¢Õߺ߰√–™“¬¥” (¡°./°°./«—π)
                Õ«—¬«–   °“√‡ª≈’ˬπ·ª≈ß∑’Ëæ∫  0    20       200     1000     2000    2000-R
                                          n=15     n=15    n=15     n=15     n=15     n=15
              ªÕ¥     Lymphoid proliferated  14/15  12/15  8/15*    8/15*    7/15*    7/15*
                      peribronchioles
              À—«„®   Focal myocardiosis (+1)  1/15  3/15   4/15    6/15*    4/15     2/15
              µ—∫     Hepatocyte degeneration  10/15  12/15  11/15  12/15    5/15     7/15
                      Protein cast deposited in  0/15  0/15  0/15   0/15     0/15     1/15
                      sinusoids (+1)
              °√–‡æ“–Õ“À“√ Submucosal edema with  0/15  0/15  1/15  0/15     0/15     0/15
                      PMN infiltration
              µ—∫ÕàÕπ  Focal nodular hyperplasia  0/15  0/15  0/15  1/15     0/15     0/15
              ≈”‰ â‡≈Á°  Lymphoid aggergated in  8/15  0/15*  0/15*  3/15    0/15*    2/15*
                      submucosa
              ≈”‰ â„À≠à                   2/15     4/15     5/15    1/15     1/15     1/15
              Õ—≤±–   Atrophy             0/15     2/15     0/15    0/15     0/15     1/15
                      Hemorrhagic supperative  0/15  0/15   0/15    0/15     0/15     1/15
                      epididymitis
              µàÕ¡À¡«°‰µ Cortical fatty degeneration  12/15  6/15*  11/15  5/15*  3/15*  1/15*
             µ—«‡≈¢„πµ“√“ß· ¥ß„π√Ÿª¢Õß®”π«πÀπŸ∑’˵√«®æ∫欓∏‘ ¿“æ/®”π«πÀπŸ∑—ÈßÀ¡¥„π°≈ÿà¡
             *·µ°µà“ß®“°°≈ÿࡧ«∫§ÿ¡Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘µ‘ (p<0.05)
             +1 À¡“¬∂÷ß °“√‡ª≈’ˬπ·ª≈ßæ∫‡æ’¬ß‡≈Á°πâÕ¬ (mild degree)
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