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Journal of Thai Traditional & Alternative Medicine                Vol. 8 No. 2 May-August (Supplement) 2010 Ù˜



                PP-4



             ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–¬—∫¬—Èß°“√ √â“߇¡Á¥ ’‡¡≈“π‘π¢Õß “√ ”§—≠®“° “√ °—¥‚°∞æÿߪ≈“


                              Ò,Ú                    Ò                  Û                 Ò,Ú
             Õ√—≠≠“ ¡‚π √âÕ¬ , ‡æÁ≠»—°¥‘Ï ®—π∑√“«ÿ∏ , ‚∑™‘Œ‘‚√à Õ–°’Œ‘´à“ , ®’√‡¥™ ¡‚π √âÕ¬
             Ò
             §≥–‡¿ —™»“ μ√å, ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à, ®.‡™’¬ß„À¡à, ª√–‡∑»‰∑¬
             Ú
             »Ÿπ¬å«‘®—¬·≈–æ—≤π“º≈‘μ¿—≥±å∏√√¡™“μ‘,  ∂“∫—π«‘®—¬«‘∑¬“»“ μ√å·≈–‡∑§‚π‚≈¬’, ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à, ®. ‡™’¬ß„À¡à, ª√–‡∑»‰∑¬
             Û
              ∂“∫—π«‘∑¬“»“ μ√å·≈–‡∑§‚π‚≈¬’ ¡À“«‘∑¬“≈—¬π‘ŒÕß ®.‚μ‡°’¬« ª√–‡∑»≠’˪ÿÉπ

                 À≈—°°“√·≈–‡Àμÿº≈ ‚°∞æÿߪ≈“ ‡ªìπ™◊ËÕ‡√’¬° ‘Ëß∑’ËπŸπªŸ¥¢÷Èπ¡“μ“¡°‘Ëß·≈–„∫¢Õßæ◊™À≈“¬™π‘¥ „π °ÿ≈ Terminalia «ß»å

             Combretaceae ‡™àπ  ¡Õ‰∑¬ (Terminalia chebula Retz.), À√◊Õ∑’Ë¿“§Õ’ “π‡√’¬°«à“ ªŸ¥ â¡¡ÕÀ√◊ÕªŸ¥ª¡¢Õßμâπ ¡Õ‰∑¬∑’Ë
             ‡°‘¥¢÷Èπ®“° à«π¢Õßæ◊™ ‡™àπ „∫ À√◊Õ °‘Ëß ∑’Ë∂Ÿ° ‘ËßÕ◊Ëπ‰ª√∫°«π ‡™àπ ·¡≈߇®“–‡¢â“‰ª‡æ◊ËÕ«“߉¢à æ◊™®÷ßμâÕߺ≈‘μ “√ªÑÕß°—π¢÷Èπ¡“
             ‚°∞æÿߪ≈“¡’√ Ω“¥ ¢¡®—¥ ¡’ √√æ§ÿ≥‡ªìπ¬“Ω“¥ ¡“π „πÕ¥’μ„™â√—°…“Ωï¿“¬„π ·°â‚√§Õÿ®®“√–√à«ß ·°â∫‘¥ ·≈–¡Ÿ°‡≈◊Õ¥

             πÕ°®“°π’È„πμ”√—∫¬“≈â“ππ“ ¡’°“√π”‚°∞æÿߪ≈“¡“„™â‡ªìπ¬“Õ“¬ÿ«—≤π–·≈–™–≈Õ§«“¡·°à ®“°¢âÕ¡Ÿ≈∑“ß«‘∑¬“»“ μ√å‚°∞æÿߪ≈“
             ¡’ “√ ”§—≠ ‰¥â·°à tannic acid, terchebulin, isoterchebulin, chebulagic acid, gallic acid ·≈– chebulinic acid ‡ªìπμâπ
                 «—μ∂ÿª√– ß§å ‡æ◊ËÕ»÷°…“ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–¬—∫¬—Èß°“√ √â“߇¡Á¥ ’‡¡≈“π‘π¢Õß “√ °—¥®“°‚°∞æÿߪ≈“
                 «‘∏’¥”‡π‘π°“√ ‰¥â·¬° “√ ”§—≠∑’Ë¡’„π “√ °—¥‚°∞æÿߪ≈“‚¥¬„™â Dianion ·≈– Octadecyl silica ¥â«¬«‘∏’§Õ≈—¡π傧√¡“
             ‚μ°√“øøï ®“°π—Èππ” “√ ”§—≠∑’Ë·¬°‰¥â¡“»÷°…“ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–¬—∫¬—Èß°“√ √â“߇¡Á¥ ’‡¡≈“π‘π ¥â«¬«‘∏’ DPPH radical scav-

             enging ·≈– α-MSH-induced melanin production on B16 murine melanoma μ“¡≈”¥—∫
                 º≈°“√»÷°…“  “√ °—¥À¬“∫¢Õß ¡ÿπ‰æ√‚°∞æÿߪ≈“„Àâƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √– Ÿß°«à“«‘μ“¡‘πÕ’·≈– BHT Ú.Û˜ ·≈– Û.˘
             ‡∑à“μ“¡≈”¥—∫ πÕ°®“°π’È chebulinic acid ·≈– gallic acid ´÷Ëß·¬°‰¥â®“° “√ °—¥ ‚°∞æÿߪ≈“¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–¡“°∑’Ë ÿ¥

             (¡’§à“§«“¡‡¢â¡¢âπ∑’Ë„Àâƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–§√÷ËßÀπ÷Ëß, SC , ‡∑à“°—∫ .˘Ù ‰¡‚§√‚¡≈“√å) ·≈–πâÕ¬∑’Ë ÿ¥ (¡’§à“§«“¡‡¢â¡¢âπ∑’Ë„Àâƒ∑∏‘Ï
                                                       50
             μâ“πÕπÿ¡Ÿ≈Õ‘ √–§√÷ËßÀπ÷Ëß, SC , ‡∑à“°—∫ ı.Ò˜ ‰¡‚§√‚¡≈“√å) μ“¡≈”¥—∫ „π¢≥–∑’Ë punicalagin ¡’ƒ∑∏‘Ϭ—∫¬—Èß √â“߇¡Á¥ ’‡¡Á¥≈“π‘π
                                   50
             ÙÒ.Ò% ‚¥¬¡’§à“¡“°°«à“ “√¡“μ√∞“π arbutin (´÷Ë߬—∫¬—Èß°“√ √â“߇¡Á¥ ’‡¡Á¥≈“π‘π‰¥â‡∑à“°—∫ ˘.ı%) ·≈– “√¡“μ√∞“π kojic acid
             (´÷Ë߬—∫¬—Èß°“√ √â“߇¡Á¥ ’‡¡Á¥≈“π‘π‰¥â‡∑à“°—∫ ¯.ı%) ‡ªìπ Ù.Û ·≈– Ù.¯ ‡∑à“μ“¡≈”¥—∫
                 ¢âÕ √ÿª Chebulinic acid ·≈– punicalagin ∑’Ë¡’„π “√ °—¥®“°‚°∞æÿߪ≈“¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–¬—∫¬—Èß°“√ √â“߇¡Á¥

              ’‡¡≈“π‘π Ÿß ÿ¥μ“¡≈”¥—∫
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