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OP-1

A standardized anti-inflammatory lotion containing the bat flowerûs extract

Chaiyong Rujjanawate

School of Health Science, Mae Fah Luang University, Chiangrai 70100. Thailand.

Rationale: Bat flower (Tacca chantrieri Andre) is a perennial herb indigenous to the tropics. The plant is

used traditionally as a pain remedy. Previous results from our laboratory demonstrated that the rhizome extract
of this plant contains saponins which were demonstrated to exhibit marked analgesic and anti-inflammatory
actions in experimental animals. It is thus justified to formulate a standardized topical product containing the

plantûs extract to be used for further clinical evaluations.
Objective: To obtain a standardized anti-inflammatory lotion containing the bat flowerûs extract.
Methodology: The bat flower rhizomes were collected from Chiangrai province in April 2009. The plant
was authenticated and the voucher specimen is deposited at the school of Health Science, Mae Fah Luang
University, Thailand. The air dried powdered rhizome was macerated with 95% ethanol overnight and filtered.
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The filtrate was concentrated in vacuo at 55 C and lyophilized to obtain a dry ethanolic extract (15.5% yields).
The extract components were analyzed by Gas chromatography/Mass spectrometry (GC/MS). To prepare a
standardized lotion, the extract was dissolved in a mixture vehicle comprising ethanol and propylene glycol.

Results: The analysis of the chromatogram indicated the presence of 9 compounds in which the most
two abundances were diosgenin (42.15%) and ethyl alpha.-d-glucopyranoside (35.79%). The lotion containing
the extract at a concentration of 2% was prepared. The obtained lotion was a clear light brown fluid with pH 7.5,
totally water miscible and yielded no sticky feeling after its topical application.
Conclusion: The standardized anti-inflammatory lotion containing the extract from the bat flower rhizome

was obtained. The lotion is being evaluated for the efficacy, safety, and investment. The preparation method
was simple and not costly and the lotion can be mass produced.