Page 42 - journal-6-2-S-Full

Journal of Thai Traditional & Alternative Medicine Vol. 6 No. 2 May-August (Supplement) 2008 ÙÒ

OR-1

ƒ∑∏‘Ï¢Õß “√ °—¥„∫À¡àÕπ (Morus alba L.) „π°“√§«∫§ÿ¡√–¥—∫πÈ”µ“≈„π‡≈◊Õ¥

ÀπŸ·√∑

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°—≈¬“ Õπÿ≈—°¢≥“ª°√≥å , ∫√√®ß ™“«‰√à , ª√–‰æ «ß»å ‘π§ß¡—Ëπ , ∑√ßæ≈ º¥ÿßæ—≤πå ,
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¬ÿ«¥’ ‡¡µµ“‡¡∏“ , «à“∑’Ë √.µ.∏π«—≤πå ∑Õß®’π , ‡√«¥’ ∫ÿµ√“¿√≥å Ú
Ò Ú
∂“∫—π«‘®—¬ ¡ÿπ‰æ√ ∂“∫—π«‘®—¬«‘∑¬“»“ µ√å “∏“√≥ ÿ¢ °√¡«‘∑¬“»“ µ√å°“√·æ∑¬å °√–∑√«ß “∏“√≥ ÿ¢
À≈—°°“√·≈–‡Àµÿº≈ ‚√§‡∫“À«“π‡ªìπªí≠À“ ÿ¢¿“æ∑’Ë ”§—≠¢Õߪ√–™“°√∑—Ë«‚≈° ‡ªìπ‚√§‡√◊ÈÕ√—ßÀ“°¡‘‰¥â√—∫°“√√—°…“
À√◊Õ‰¥â√—∫°“√√—°…“∑’ˉ¡à‡À¡“– ¡®–𔉪 Ÿà¿“«–·∑√°´âÕπ∑’Ë√ÿπ·√ß ·≈–‡ªì𠓇Àµÿ°“√µ“¬∑’Ë ”§—≠ ·æ∑¬åæ◊Èπ∫â“π
„πÀ≈“¬ª√–‡∑»„™â„∫À¡àÕπ (Morus alba L.) ”À√—∫√—°…“‡∫“À«“π ·≈–¡’√“¬ß“π«à“ “√ DNJ (Deoxynojirimycin)

·≈– “√ °—¥®“°„∫À¡àÕπ¡’ƒ∑∏‘Ϭ—∫¬—Èß°“√∑”ß“π¢Õ߇ÕÁπ‰´¡å disaccharidase „πÀ≈Õ¥∑¥≈Õß ¥—ßπ—Èπ®÷ßπà“ π„®∑’Ë®–
∑”°“√»÷°…“ƒ∑∏‘Ï¢Õß “√ °—¥„∫À¡àÕπµàÕ¿“«– postprandial hyperglycemia

«—µ∂ÿª√– ß§å »÷°…“ƒ∑∏‘Ï¢Õß “√ °—¥πÈ” (WMA) ı% ‡Õ∑“πÕ≈ (AEMA) ˘ı% ‡Õ∑“πÕ≈ (EMA) ®“°„∫À¡àÕπ
·≈– “√ °—¥·¬° à«π®“° “√ °—¥ ˘ı% ‡Õ∑“πÕ≈ [ “√ °—¥ ˘ı% ‡Õ∑“πÕ≈∑’Ë≈–≈“¬πÈ” (EMA-F1) ·≈– “√ °—¥
˘ı% ‡Õ∑“πÕ≈∑’Ë≈–≈“¬„π‡Õ∑“πÕ≈ (EMA-F2)] µàÕ postprandial glucose ¢ÕßÀπŸ·√∑ª°µ‘·≈–ÀπŸ·√∑‡∫“À«“π
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‡ª√’¬∫‡∑’¬∫°—∫¬“ Glucobay ·≈–À“°≈ÿà¡ “√ÕÕ°ƒ∑∏‘Ï
«‘∏’¥”‡π‘π°“√ ÀπŸ·√∑‡æ»ºŸâ “¬æ—π∏ÿå Sprague Dawley ∑—ÈßÀπŸª°µ‘ ·≈–ÀπŸ∑’Ë∂Ÿ°‡Àπ’ˬ«π”„À⇪ìπ‡∫“À«“π¥â«¬

alloxan ∂Ÿ°·∫àß·∫∫ ÿà¡ÕÕ°‡ªìπ ı °≈ÿà¡ °≈ÿà¡≈– ˆ µ—« ¥—ßπ’È °≈ÿࡧ«∫§ÿ¡ °≈ÿà¡∑’ˉ¥â√—∫ WMA À√◊Õ AEMA À√◊Õ EMA
∑“ߪ“° (oral gavage) ¢π“¥ ÒÚı, Úı ·≈– ı ¡°./°°. À√◊Õ‰¥â√—∫ EMA-F1 À√◊Õ EMA-F2 ¢π“¥ ı, Ò
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·≈– Ú ¡°./°°. ·≈–°≈ÿà¡∑’ˉ¥â√—∫ Glucobay ¢π“¥ Ú À√◊Õ Ù ¡°./°°. ÀπŸ∑ÿ°°≈ÿࡉ¥â√—∫ “√≈–≈“¬´Ÿ‚§√ ∑“ß
ª“°¢π“¥ Ú °./°°. æ√âÕ¡ “√ °—¥ «—¥√–¥—∫πÈ”µ“≈„π‡≈◊Õ¥°àÕπ‰¥â√—∫πÈ”µ“≈·≈–À≈—ß®“°‰¥â√—∫πÈ”µ“≈ .ı, Ò, Ú, Û
·≈– ı ™—Ë«‚¡ß ‡ª√’¬∫‡∑’¬∫√–¥—∫πÈ”µ“≈„π‡≈◊Õ¥∑’ˇæ‘Ë¡¢÷Èπ¢ÕßÀπŸ·µà≈–°≈ÿà¡∑’Ë·µà≈–‡«≈“

º≈°“√»÷°…“ √–¥—∫πÈ”µ“≈„π‡≈◊Õ¥ÀπŸ°≈ÿࡧ«∫§ÿ¡‡æ‘Ë¡¢÷Èπ®π∂÷ß√–¥—∫ Ÿß ÿ¥À≈—ß®“°‰¥â√—∫´Ÿ‚§√ Ò ™—Ë«‚¡ß ®“°π—Èπ®÷ß
§àÕ¬ Ê ≈¥≈ß WMA, AEMA ·≈– EMA ∑”„Àâ postprandial glucose ∑—ÈߢÕßÀπŸª°µ‘·≈–ÀπŸ‡∫“À«“π‡æ‘Ë¡¢÷ÈππâÕ¬
°«à“°≈ÿࡧ«∫§ÿ¡ ‚¥¬ EMA „Àâº≈¥’∑’Ë ÿ¥ ”À√—∫ “√ °—¥·¬° à«π æ∫«à“ EMA-F2 ‰¡à¡’º≈µàÕ postprandial glucose

„π¢≥–∑’Ë EMA-F1 ∑ÿ°¢π“¥∑’Ë∑¥≈Õß∑”„Àâ postprandial glucose ∑—ÈߢÕßÀπŸª°µ‘·≈–ÀπŸ‡∫“À«“ππâÕ¬°«à“°≈ÿà¡
§«∫§ÿ¡µ≈Õ¥°“√∑¥≈Õß ‚¥¬∑’Ë¢π“¥ Ò ¡°./°°. „πÀπŸª°µ‘ ·≈–¢π“¥ Ú ¡°./°°. „πÀπŸ‡∫“À«“πÕÕ°ƒ∑∏‘Ï
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‰¥â¥’°«à“ Glucobay ¢π“¥ Ù ¡°./°°. ‡≈Á°πâÕ¬ ·≈–æ∫«à“ “√∑’ËÕÕ°ƒ∑∏‘χªìπ “√°≈ÿࡇø≈‚«πÕ¬¥å·≈–‰°≈‚§‰´¥å
¢âÕ √ÿª “√ °—¥„∫À¡àÕπ∑”„Àâ postprandial glucose ∑—ÈߢÕßÀπŸ·√∑ª°µ‘·≈–ÀπŸ·√∑‡∫“À«“π≈¥≈ß ·≈– “√∑’ËÕÕ°
ƒ∑∏‘χªìπ “√°≈ÿࡇø≈‚«πÕ¬¥å·≈–‰°≈‚§‰´¥å ®÷ß¡’»—°¬¿“æ„π°“√𔉪æ—≤𓇪ìπº≈‘µ¿—≥±å„™â„π°“√ªÑÕß°—π°“√‡°‘¥

‡∫“À«“π„πª√–™“°√°≈ÿࡇ ’ˬß∑’Ë¡’¿“«–Õâ«π À√◊Õ glucose intolerance À√◊Õ„™â„π°“√§«∫§ÿ¡ postprandial hyperglyce-
mia ´÷Ë߇ªìπªí®®—¬‡ ’Ë¬ß ”§—≠µàÕ°“√‡°‘¥¿“«–·∑√°´âÕπ∑’Ë√ÿπ·√ß„πºŸâªÉ«¬‡∫“À«“π