Page 145 - Acrobat J Trad-21-3-2566

628 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 3 กันยายน-ธันวาคม 2566

3. In vitro inhibitory activity on acetylcho- highest inhibitory activity on BuChE, similar
linesterase and butyrylcholinesterase to AChE, with IC50 of 64.40 ± 16.74 µg/mL and

The inhibitory effects of Kratom extracts 127.99 ± 6.15 µg/mL, respectively. However,
on AChE and BuChE were investigated as a all extracts exhibited lower inhibitory effects
model of anti-Alzheimer’s disease. All extracts than the positive control, donepezil. Addition-

tended to have inhibitory activity on both ally, Kratom extracts were found to have better
AChE and BuChE enzymes. Consequently, the inhibitory activity on BuChE as compared to
IC50 of all extracts were evaluated, as shown in AChE.

Figure 2. Of all the extracts, KE95 exerted the

Figure 2 Inhibitory activity (IC 50, µg/mL) of Kratom extracts on acetylcholinesterase (a) and butyrylcholinesterase
(b). The different alphabets above the bar graph show statistically significant differences (p-value <
0.05) analyzing by one way ANOVA with Tukey’s multiple comparison test. (AChE: a-c; BuChE: d-f).