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                 2.1 °“√«‘‡§√“–Àå¢âÕ¡Ÿ≈                  ∑«à“¡’º≈°“√μ√«®‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√‡æ‘Ë¡¢÷Èπ

                 «‘‡§√“–Àå∑“ß ∂‘μ‘¥â«¬ √âÕ¬≈–, §à“‡©≈’ˬ, paired  Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ 3 √“¬°“√ §◊Õ ®”π«π
             t-test, Repeated One way ANOVA ·≈– Kaplan   ‡¡Á¥‡≈◊Õ¥¢“«™π‘¥π‘«‚∑√øî≈ (%Neutrophils), §à“

             Meier method ‚¥¬„™âÀ≈—° intention to treat  Blood Urea Nitrogen (BUN) ·≈–§à“‡Õπ‰´¡åÕ—≈
                                                         §“‰≈πåøÕ ø“‡μ  (Alkaline phosphatase: ALP)
                           º≈°“√»÷°…“
                                                         ·μଗßÕ¬Ÿà„π‡°≥±åª°μ‘ ∑—Èßπ’ȉ¡àæ∫°“√√“¬ß“π

                 ®“°ºŸâ‡¢â“√à«¡«‘®—¬∑—Èß ‘Èπ®”π«π 44 √“¬ ¡’ºŸâ‡¢â“  Õ“°“√‰¡àæ÷ߪ√– ß§å√ÿπ·√ß„¥ √“¬≈–‡Õ’¬¥¥—ßμ“√“ß
             √à«¡«‘®—¬∑’Ë¡’§ÿ≥ ¡∫—쑧√∫μ“¡‡°≥±å∑’Ë°”Àπ¥·≈–  ∑’Ë 2

              “¡“√∂μ‘¥μ“¡º≈‰¥â§√∫∑—Èß ‘Èπ®”π«π 32 √“¬ ¡’     ∑—Èßπ’È ‡¡◊ËÕ«‘‡§√“–Àå„π√“¬≈–‡Õ’¬¥º≈°“√μ√«®
             §à“‡©≈’ˬ¢ÕßÕ“¬ÿ·≈–¥—™π’¡«≈°“¬∑’Ë 53.31 ± 10.29  ‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√∑—Èß 3 √“¬°“√∑’ˇæ‘Ë¡¢÷ÈπÕ¬à“ß
             ªï·≈– 22.64 ± 4.28 °‘‚≈°√—¡/μ“√“߇¡μ√ μ“¡≈”¥—∫  ¡’π—¬ ”§—≠∑“ß ∂‘μ‘ §◊Õ ®”π«π‡¡Á¥‡≈◊Õ¥¢“«™π‘¥

             °«à“√âÕ¬≈– 90 ¡’√–¥—∫ ECOG (Eastern Coopera-  π‘«‚∑√øî≈ (%Neutrophils), §à“ Blood Urea Ni-
             tive Oncology Group) Õ¬Ÿà∑’Ë 0 À¡“¬∂÷ߺŸâªÉ«¬  trogen (BUN) ·≈–§à“‡Õπ‰´¡åÕ—≈§“‰≈πåøÕ ø“‡μ 
              “¡“√∂ªØ‘∫—μ‘ß“π‰¥âμ“¡ª°μ‘ ‰¡à¡’Õ“°“√· ¥ß¢Õß  (Alkaline phosphatase: ALP) æ∫«à“¡’‡æ’¬ß

             ‚√§ πÕ°®“°π’Ȭ—ßæ∫«à“ §à“‡©≈’ˬ —≠≠“≥™’æμà“ß Ê  ®”π«π‡¡Á¥‡≈◊Õ¥¢“« ™π‘¥π‘«‚∑√øî≈ (%Neutrophils)
             ¢ÕߺŸâ‡¢â“√à«¡«‘®—¬Õ¬Ÿà„π™à«ßª°μ‘ √“¬≈–‡Õ’¬¥  ‡∑à“π—Èπ∑’Ë —¡æ—π∏å°—∫°“√μÕ∫ πÕßμàÕ¬“ N040 μ“¡
             ≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ¢ÕߺŸâ‡¢â“√à«¡  RECIST Criteria °≈à“«§◊Õ °≈ÿà¡∑’ËμÕ∫ πÕßμàÕ¬“

             «‘®—¬„π‚§√ß°“√¥—ßμ“√“ß∑’Ë 1                 N040 ¡’√–¥—∫π‘«‚∑√øî≈ (Neutrophil) ‡æ‘Ë¡¢÷Èπ‡ªìπ
                 º≈°“√μ√«®‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√°àÕπ·≈–  ®”π«π¡“°°«à“°≈ÿà¡∑’ˉ¡àμÕ∫ πÕßμàÕ¬“ N040

             À≈—ß√—∫ª√–∑“π¬“¢ÕߺŸâ‡¢â“√à«¡«‘®—¬Õ¬Ÿà„π√–¥—∫ª°μ‘  Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ (p = 0.008)




             μ“√“ß∑’Ë 1 ≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ¢ÕߺŸâ‡¢â“√à«¡«‘®—¬„π‚§√ß°“√
                    ≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ·√°‡¢â“‚§√ß°“√           ®”π«πºŸâ‡¢â“√à«¡«‘®—¬ (n = 32)

             Õ“¬ÿ (ªï:§à“‡©≈’ˬ ±  à«π‡∫’ˬ߇∫π¡“μ√∞“π)                       53.31 ± 10.29
             §à“¥—™π’¡«≈°“¬ (°‘‚≈°√—¡/μ“√“߇¡μ√:§à“‡©≈’ˬ ±  à«π‡∫’ˬ߇∫π¡“μ√∞“π)  22.64 ± 4.28
             §à“ ECOG √–¥—∫ 0                                                   29 (90.62)
              —≠≠“≥™’æ (§à“‡©≈’ˬ ±  à«π‡∫’ˬ߇∫π¡“μ√∞“π)
               ™’æ®√ (§√—ÈßμàÕπ“∑’)                                           89.47 ± 12.10
               Õ—μ√“°“√À“¬„® (§√—ÈßμàÕπ“∑’)                                    20.00 ± 0.00
               Õÿ≥À¿Ÿ¡‘√à“ß°“¬ (Õß»“‡´≈‡´’¬ )                                  36.64 ± 0.39
               §«“¡¥—π‚≈À‘μ´‘ ‚μ≈‘§ (¡‘≈≈‘‡¡μ√ª√Õ∑)                           121.66 ± 17.23
               §«“¡¥—π‚≈À‘쉥·Õ ‚μ≈‘§ (¡‘≈≈‘‡¡μ√ª√Õ∑)                         75.84 ± 11.61
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