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2.1 °“√«‘‡§√“–Àå¢âÕ¡Ÿ≈ ∑«à“¡’º≈°“√μ√«®‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√‡æ‘Ë¡¢÷Èπ
«‘‡§√“–Àå∑“ß ∂‘μ‘¥â«¬ √âÕ¬≈–, §à“‡©≈’ˬ, paired Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ 3 √“¬°“√ §◊Õ ®”π«π
t-test, Repeated One way ANOVA ·≈– Kaplan ‡¡Á¥‡≈◊Õ¥¢“«™π‘¥π‘«‚∑√øî≈ (%Neutrophils), §à“
Meier method ‚¥¬„™âÀ≈—° intention to treat Blood Urea Nitrogen (BUN) ·≈–§à“‡Õπ‰´¡åÕ—≈
§“‰≈πåøÕ ø“‡μ (Alkaline phosphatase: ALP)
º≈°“√»÷°…“
·μଗßÕ¬Ÿà„π‡°≥±åª°μ‘ ∑—Èßπ’ȉ¡àæ∫°“√√“¬ß“π
®“°ºŸâ‡¢â“√à«¡«‘®—¬∑—Èß ‘Èπ®”π«π 44 √“¬ ¡’ºŸâ‡¢â“ Õ“°“√‰¡àæ÷ߪ√– ߧå√ÿπ·√ß„¥ √“¬≈–‡Õ’¬¥¥—ßμ“√“ß
√à«¡«‘®—¬∑’Ë¡’§ÿ≥ ¡∫—쑧√∫μ“¡‡°≥±å∑’Ë°”Àπ¥·≈– ∑’Ë 2
“¡“√∂μ‘¥μ“¡º≈‰¥â§√∫∑—Èß ‘Èπ®”π«π 32 √“¬ ¡’ ∑—Èßπ’È ‡¡◊ËÕ«‘‡§√“–Àå„π√“¬≈–‡Õ’¬¥º≈°“√μ√«®
§à“‡©≈’ˬ¢ÕßÕ“¬ÿ·≈–¥—™π’¡«≈°“¬∑’Ë 53.31 ± 10.29 ‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√∑—Èß 3 √“¬°“√∑’ˇæ‘Ë¡¢÷ÈπÕ¬à“ß
ªï·≈– 22.64 ± 4.28 °‘‚≈°√—¡/μ“√“߇¡μ√ μ“¡≈”¥—∫ ¡’π—¬ ”§—≠∑“ß ∂‘μ‘ §◊Õ ®”π«π‡¡Á¥‡≈◊Õ¥¢“«™π‘¥
°«à“√âÕ¬≈– 90 ¡’√–¥—∫ ECOG (Eastern Coopera- π‘«‚∑√øî≈ (%Neutrophils), §à“ Blood Urea Ni-
tive Oncology Group) Õ¬Ÿà∑’Ë 0 À¡“¬∂÷ߺŸâªÉ«¬ trogen (BUN) ·≈–§à“‡Õπ‰´¡åÕ—≈§“‰≈πåøÕ ø“‡μ
“¡“√∂ªØ‘∫—μ‘ß“π‰¥âμ“¡ª°μ‘ ‰¡à¡’Õ“°“√· ¥ß¢Õß (Alkaline phosphatase: ALP) æ∫«à“¡’‡æ’¬ß
‚√§ πÕ°®“°π’Ȭ—ßæ∫«à“ §à“‡©≈’ˬ —≠≠“≥™’æμà“ß Ê ®”π«π‡¡Á¥‡≈◊Õ¥¢“« ™π‘¥π‘«‚∑√øî≈ (%Neutrophils)
¢ÕߺŸâ‡¢â“√à«¡«‘®—¬Õ¬Ÿà„π™à«ßª°μ‘ √“¬≈–‡Õ’¬¥ ‡∑à“π—Èπ∑’Ë —¡æ—π∏å°—∫°“√μÕ∫ πÕßμàÕ¬“ N040 μ“¡
≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ¢ÕߺŸâ‡¢â“√à«¡ RECIST Criteria °≈à“«§◊Õ °≈ÿà¡∑’ËμÕ∫ πÕßμàÕ¬“
«‘®—¬„π‚§√ß°“√¥—ßμ“√“ß∑’Ë 1 N040 ¡’√–¥—∫π‘«‚∑√øî≈ (Neutrophil) ‡æ‘Ë¡¢÷Èπ‡ªìπ
º≈°“√μ√«®‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√°àÕπ·≈– ®”π«π¡“°°«à“°≈ÿà¡∑’ˉ¡àμÕ∫ πÕßμàÕ¬“ N040
À≈—ß√—∫ª√–∑“π¬“¢ÕߺŸâ‡¢â“√à«¡«‘®—¬Õ¬Ÿà„π√–¥—∫ª°μ‘ Õ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ (p = 0.008)
μ“√“ß∑’Ë 1 ≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ¢ÕߺŸâ‡¢â“√à«¡«‘®—¬„π‚§√ß°“√
≈—°…≥–ª√–™“°√·≈–¢âÕ¡Ÿ≈ ÿ¢¿“æ·√°‡¢â“‚§√ß°“√ ®”π«πºŸâ‡¢â“√à«¡«‘®—¬ (n = 32)
Õ“¬ÿ (ªï:§à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π) 53.31 ± 10.29
§à“¥—™π’¡«≈°“¬ (°‘‚≈°√—¡/μ“√“߇¡μ√:§à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π) 22.64 ± 4.28
§à“ ECOG √–¥—∫ 0 29 (90.62)
—≠≠“≥™’æ (§à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π)
™’æ®√ (§√—ÈßμàÕπ“∑’) 89.47 ± 12.10
Õ—μ√“°“√À“¬„® (§√—ÈßμàÕπ“∑’) 20.00 ± 0.00
Õÿ≥À¿Ÿ¡‘√à“ß°“¬ (Õß»“‡´≈‡´’¬ ) 36.64 ± 0.39
§«“¡¥—π‚≈À‘μ´‘ ‚μ≈‘§ (¡‘≈≈‘‡¡μ√ª√Õ∑) 121.66 ± 17.23
§«“¡¥—π‚≈À‘쉥·Õ ‚μ≈‘§ (¡‘≈≈‘‡¡μ√ª√Õ∑) 75.84 ± 11.61