Page 19 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 3 ฉบับที่ 1

«“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë Û ©∫—∫∑’Ë Ò µÿ≈“§¡ ÚıÙ˜-¡°√“§¡ ÚıÙ¯ 17

°“√∑¥ Õ∫§«“¡ª≈Õ¥¿—¬¢Õß

“√ °—¥‡∂“«—≈¬å‡ª√’¬ß„π

Õ“ “ ¡—§√ ÿ¢¿“楒

Safety of Derris scandens Hydroalcoholic Extract

in Healthy Volunteers

ª√“≥’ ™«≈‘µ∏”√ß 1* ¥ÿ¥’ √—µπ“®√— ‚√®πå 1
Pranee Chavalittumrong 1* Sadudee Rattanajarasroj 1
∫ÿ…√“«√√≥ »√’«√√∏π 2 ª√“≥’ ®—π∑√‡æÁ™√ 2
Busarawan Sriwanthana 2 Pranee Chantapet 2
»‘√‘¡“ ªí∑¡¥‘≈° 2 π.æ.‰æ®‘µ√å «√“™‘µ 3
Sirima Pattamadilok 2 Paijit Warachit 3

Abstract

A phase 1 trial was performed in 12 healthy volunteers to primarily investigate
safety of Derris scandens as well as to preliminary assess its effects on immune system.

The volunteers received 400 mg/day of D. scandens hydroalcoholic extract (200 mg b.i.d.)
for 2 months. No major side effects were reported from any of the subjects throughout the
study. It was found that any significant changes in hematological and biochemical param-

eters were within normal limits. A significant rise in the frequencies of subjects with
increasing amounts of IL-2, IL-4 and IL-6 after administration was shown. Our results
suggested that the hydroalcoholic extract of D. scandens at the dose of 400 mg/day given

to normal volunteers for 2 months was safe and could induce the secretion of cytokines that
might help in modulating immune responses.

1 Medicinal Plant Research Institute
2 National Institute of Health
3. Õ∏‘∫¥’°√¡«‘∑¬“»“ µ√å°“√·æ∑¬å
Department of Medical Sciences 88/7 Soi Bamrasnaradura, Tivanond Rd., Nonthaburi 11000, Thailand

Fax: [662] 589-9866 E-mail: praneec@dmsc.moph.go.th
* corresponding author