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Regimen". That study received Charles C. Sheperd Award, in May 2000. The Sheperd

Award is a prestigious scientific award given by the US CDC to her staff for the best
research work annually since 1986. This was the first time that tearn of joint Thai and US
scientists received this award.

Now let's get back to the vaccine trial again, UNAIODS as an international

organization responsible for AIDS control and prevention has tried to gather consensus for
the ethical problems regarding vaccine testing in human. UNAIDS has organized meetings
in many regions including Asia, Africa, America and Europe. The consensus has not been

finalized for many issues. Finally it became a guidance for "Ethical considerations in HIV
preventive vaccine research" which is accepted worldwide.

The AIDSVAX Phase III Trial in Thailand has completed with a very
disappointing result. The candidate vaccine which has been proved that it is safe and can

stimulate some immune response in human, but it has no efficacy to prevent the infection,
or even to alleviate the disease progression. However, there are some satisfactory outcome
that I would like to make observations as follows:

Ô Although this study was conducted in the developing country like Thailand,
we can demonstrate that we can follow the standard ICH GCP Guideline, both
on quality of data and the protection of human subjects.
With the state of the art for subject counseling, the incidence rate of
infection among subjects in this study reduced by 50%, instead of increasing

as has been a concern before the study.

Ô The project has contributed to capacity building for researchers, specimens

repository system, and the data management experience in the country.

The keys for both successes resulted from a continuing preparation,
collaboration mid coordination and can be summarized as follow:

1) The international organization, especially UNAIDS has done a good job both
in scientific as well as ethical areas.