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√Ÿª∑’Ë 2 ‚§√ß √â“ߢÕß Delta-9-tetrahydrocannabinol
√Ÿª∑’Ë 1 °—≠™“ (Cannabis sativa) (THC)
·À≈àß∑’Ë¡“: https://sites.google.com/site/cannabis ·À≈àß∑’Ë¡“: https://upload.wikimedia.org/wikipedia/
thailands/laksna-khxng-kaycha commons/4/4c/Tetrahydrocannabinol.svg

μàÕ√–∫∫ª√– “∑∑’Ë ”§—≠´÷Ëßæ∫Õ¬Ÿà∑’Ë„∫·≈–™àÕ¥Õ° Õ“°“√‡ªìπæ‘…‡©’¬∫æ≈—π®–æ∫ “√π’ȧßÕ¬Ÿà‰¥âπ“π∂÷ß 8
μ—«‡¡’¬¢Õß°—≠™“ «—π ¡’√“¬ß“π«à“ºŸâ‡ æμ‘¥μàÕ°—ππ“π Ê ®–¡’Õ“°“√
[7-9]
°≈‰°°“√ÕÕ°ƒ∑∏‘Ï¢Õß “√ THC „π°—≠™“ §◊Õ À≈Õ¥≈¡Õ—°‡ ∫ ·≈–‰Õ‡√◊ÈÕ√—ß
“√ THC ®–‡¢â“®—∫°—∫μ—«√—∫®”‡æ“– ‰¥â·°à canna- π—°«‘∑¬“»“ μ√剥âπ”°≈‰°°“√ÕÕ°ƒ∑∏‘Ï∑’Ë¡’º≈

binoid receptor 1 (CB1) ·≈– cannabinoid re- °√–μÿâ𧫓¡Õ¬“°Õ“À“√·≈– àߺ≈≈¥Õ“°“√
ceptor 2 (CB2) ‚¥¬μ—«√—∫ CB1 ®–æ∫¡“°∑’Ë §≈◊Ëπ‰ â¡“ª√–¬ÿ°μå„™â∑“ߧ≈‘π‘°°—∫ºŸâªÉ«¬‚√§‡Õ¥ å
¡Õß‚¥¬‡©æ“–„π à«π hippocampus, frontal ce- ·≈–ºŸâªÉ«¬‚√§¡–‡√Áß∑’ËμâÕß„™â¬“‡§¡’∫”∫—¥·≈–/À√◊Õ

rebral cortex, cerebellum, basal ganglia, stria- ‚√§¡–‡√Áß√–¬– ÿ¥∑⓬ °—≠™“æ∫‰¥âÀ≈“¬ “¬æ—π∏ÿå
tum ´÷Ë߇ªìπ à«π∑’˧«∫§ÿ¡Õ“√¡≥姫“¡√Ÿâ ÷° ÿ¢ ∫“¬ „π·μà≈– “¬æ—π∏ÿå®–„Àâº≈°“√√—°…“∑’Ë·μ°μà“ß°—π
[1,2]
§«“¡§‘¥ §«“¡®” πÕ°®“°π’Ȭ—ß¡’º≈μàÕ ¡Õß à«π∑’Ë πÕ°®“°π’Ȭ—ߢ÷Èπ°—∫«‘∏’°“√∑’Ë°—≠™“‡¢â“ Ÿà√à“ß°“¬
√—∫√Ÿâ ‡™à𠧫“¡°—ß«≈ §«“¡‡®Á∫ª«¥ °“√√—∫√Ÿâ§«“¡
°“√§«∫§ÿ¡°“√„™â°—≠™“∑“ß°“√·æ∑¬å
√Ÿâ ÷° °“√§«∫§ÿ¡√–∫∫°“√‡§≈◊ËÕπ‰À«¢Õß√à“ß°“¬

·≈–√–∫∫μàÕ¡‰√â∑àÕ à«πμ—«√—∫ CB2 æ∫∑’Ë√–∫∫ °ÆÀ¡“¬¬“‡ æμ‘¥∑’˧«∫§ÿ¡°“√„™âæ◊™°—≠™“
¿Ÿ¡‘§ÿâ¡°—π¢Õß√à“ß°“¬ (splenic macrophages, T ¢Õß·μà≈–ª√–‡∑»®–·μ°μà“ß°—π‰ª ‡™àπ „πª√–‡∑»
and B lymphocytes) ‡ âπª√– “∑ à«πª≈“¬ ‚¥¬ À√—∞Õ‡¡√‘°“®—¥„Àâ°—≠™“Õ¬Ÿà„π√“¬°“√¬“‡ æμ‘¥„Àâ

∑—Ë«‰ªºŸâ‡ æ¡—°„™â«‘∏’ Ÿ¥¥¡§«—πºà“π‡¢â“‰ª„πªÕ¥ ‚∑…ª√–‡¿∑∑’Ë 1 (schedule I) ‡™àπ‡¥’¬«°—∫ heroin,
∑”„Àâ “√´÷¡‡¢â“°√–· ‚≈À‘μ·≈–ÕÕ°ƒ∑∏‘ÏμàÕ√–∫∫ LSD, mescaline, methaqualone, and gamma-
ª√– “∑¿“¬„π‰¡à°’Ëπ“∑’ ·≈–§ßÕ¬Ÿà„π√à“ß°“¬‰¥â hydroxybutyrate (GHB) ·μà¡’¢âÕ¬°‡«âπ·μ°μà“ß

π“π∂÷ß 6 ™—Ë«‚¡ß THC ®–∂Ÿ°‡ª≈’ˬπ„À⇪ìπ “√‰Œ- °—π„π·μà≈–√—∞ ª√–‡∑»·§π“¥“®—¥„Àâ°—≠™“Õ¬Ÿà„π
¥√Õ°´’ ‡μμ√“‰Œ‚¥√·§ππ“∫‘πÕ≈ (11-OH tetrahy- √“¬°“√¬“‡ æμ‘¥„Àâ‚∑…ª√–‡¿∑∑’Ë 2 (schedule II)

drocannabinol) ¿“¬„π 10 π“∑’ “√π’È®–μ√«® ·≈–ª√–‡∑»Õ—ß°ƒ…®—¥„Àâ°—≠™“Õ¬Ÿà„π class C
[1]
æ∫‰¥â„πªí “«– °√≥’∑’ˇ æ¡“°‡°‘π¢π“¥®π‡°‘¥ drug ”À√—∫ª√–‡∑»‰∑¬®—¥‡ªì𬓇 æμ‘¥„Àâ‚∑…