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√Ÿª∑’Ë 4 Ÿμ√‚§√ß √â“ߢÕß “√‡§¡’∫“ß™π‘¥∑’Ëæ∫„π√“°¢ÕßÀ≠ⓧ“

¡’√“¬ß“πƒ∑∏‘Ï∑“߇¿ —™«‘∑¬“√“°¢ÕßÀ≠ⓧ“ À¥μ—«¢ÕßÀ≈Õ¥‡≈◊Õ¥∑—ÈßÀ¡¥∑’ˇ°‘¥®“°°“√°√–μÿâπ
10-13
-7
æ∫«à“ “√ °—¥¥â«¬‡¡∑“πÕ≈·≈–πÈ” ‰¥â·°à ¥â«¬ norepinephine ∑’˧«“¡‡¢â¡¢âπ 1 × 10 M
10 11 12
-4
cylindrene , cylindol A , graminone B ·≈– ·≈– “√ graminone B ∑’˧«“¡‡¢â¡¢âπ 4 × 10 M
13
imperarene cylindrene ·≈– graminone ¡’ƒ∑∏‘Ï “¡“√∂¬—∫¬—Èß°“√À¥μ—«¢ÕßÀ≈Õ¥‡≈◊Õ¥ aorta
„π°“√¬—∫¬—Èß°“√∑”ß“π¢Õß°≈â“¡‡π◊ÈÕ‡√’¬∫∫√‘‡«≥ ¢Õß°√–μà“¬‰¥â 50% ¢Õß°“√À¥μ—«¢ÕßÀ≈Õ¥‡≈◊Õ¥
10,12
À≈Õ¥‡≈◊Õ¥ aorta ¢Õß°√–μà“¬ ‚¥¬ cylin- ∑—ÈßÀ¡¥∑’ˇ°‘¥®“°°“√°√–μÿâπ¥â«¬ KCl ∑’˧«“¡‡¢â¡¢âπ
-4
drene ∑’˧«“¡‡¢â¡¢âπ 3 × 10 M ¬—∫¬—Èß°“√À¥μ—« 30 mM 12 ”À√—∫ “√ cylindol A ¡’ƒ∑∏‘Ï„π°“√
¢ÕßÀ≈Õ¥‡≈◊Õ¥ aorta ¢Õß°√–μà“¬‰¥â 40% ¢Õß°“√ ¬—∫¬—Èß “√ 5 -lypoxygenase ´÷Ë߇°’ˬ«¢âÕß°—∫ƒ∑∏‘Ï