Page 43 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 3 ฉบับที่ 3

«“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë Û ©∫—∫∑’Ë Û ¡‘∂ÿπ“¬π -°—𬓬π ÚıÙ¯ 41

¬“ ‡§√◊ËÕß ”Õ“ß ·≈–º≈‘µ¿—≥±å‡ √‘¡Õ“À“√ µ≈Õ¥®π°“√·æ∑¬å∑“߇≈◊Õ°Õ◊ËπÊ ‡™àπ ÿ«§π∏∫”∫—¥

(aromatherapy) °“√π«¥ ™à«¬°√–µÿâπ°“√‰À≈‡«’¬π¢Õß‚≈À‘µ ∑”„ÀâºàÕπ§≈“¬ ™à«¬„ÀâÀ≈—∫À√◊Õ ß∫
2
®‘µ„® √–ß—∫°≈‘Ëπ ∑”„Àâ ¥™◊Ëπ πÕ°®“°π’È ¡’√“¬ß“π∂÷ß°“√π”¡“„™âª√–‚¬™πå∑’ËÀ≈“°À≈“¬ µ—«Õ¬à“߇™àπ
1
3-9
ƒ∑∏‘Ï¢—∫ªí “«– „™â‡æ◊ËÕªÑÕß°—π°”®—¥·¡≈ß∑“ß°“√·æ∑¬å ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √– (free-radical scav-
12-20
10-11
enging activity) ƒ∑∏‘ϵâ“πÕÕ°´‘·¥π∑å (antioxidant) ƒ∑∏‘ϵâ“π®ÿ≈‘π∑√’¬åÀ√◊Õ‡™◊ÈÕ√“À√◊Õ‡™◊ÈÕ
16-19
‰«√— „π∑“߇§√◊ËÕß ”Õ“ßÕ“®„™âπÈ”¡—πÀÕ¡√–‡À¬‡æ◊ËÕ·µàß°≈‘Ëπ„ππÈ”ÀÕ¡ ‡æ‘Ë¡§«“¡™ÿà¡™◊Èπ·≈–§«“¡
21
¬◊¥À¬ÿàπ¢Õߺ‘«Àπ—ß À√◊Õ‡æ‘Ë¡§«“¡‡ß“ß“¡‡ªìπª√–°“¬¢Õ߇ â㧭 ”À√—∫ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √–π—Èπ ¡’
√“¬ß“π«à“ πÈ”¡—πÀÕ¡√–‡À¬∑’Ë¡’Õߧåª√–°Õ∫∑“߇§¡’‡ªìπ “√ª√–‡¿∑øï‚π≈‘°®–¡’ƒ∑∏‘Ï¥—ß°≈à“« ‡™àπ
thymol, carvacrol, eugenol, carvone, thujone (¥Ÿ Ÿµ√‚§√ß √â“ß„π√Ÿª∑’Ë 1) Õ“®‡π◊ËÕß¡“®“° “√

ª√–‡¿∑øï‚π≈‘°¡’§ÿ≥ ¡∫—µ‘„π°“√‡ªìπ “√µâ“πÕπÿ¡Ÿ≈Õ‘ √–‰¥â ‚¥¬°“√„À≌‚¥√‡®π Õ–µÕ¡°—∫ alkoxy
radicals À√◊Õ peroxyl radicals º≈º≈‘µ∑’ˉ¥â§◊Õ Õπÿ¡Ÿ≈Õ‘ √– phenoxy ∑’Ë¡’§«“¡§ßµ—« Ÿß (‡π◊ËÕß¡“
®“°°“√¡’ delocalisation ¢ÕßÕ‘‡≈°µ√Õπ§Ÿà‚¥¥‡¥’ˬ«„π aromatic ring) ´÷Ëß®–‰ª≈¥°“√∑”
ªØ‘°‘√‘¬“√–À«à“ßÕπÿ¡Ÿ≈Õ‘ √–°—∫‰¢¡—π (lipid peroxidation inhibition) πÕ°®“°π’È À“°¡’
°≈ÿࡉŒ¥√Õ°´’‡æ‘Ë¡¢÷Èπ∑’˵”·Àπàß ortho À√◊Õ para ¢Õß phenolic ring ®–¬‘Ë߇æ‘Ë¡ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √–

‡π◊ËÕß®“°‡°‘¥æ—π∏–‰Œ‚¥√‡®π¿“¬„π‚¡‡≈°ÿ≈ (intramolecular hydrogen-bonding)‹ ´÷Ëߙ૬„Àâ
phenoxyl radicals ¡’§«“¡§ßµ—«¡“°¢÷Èπ 22-24

α - Pinene β - Pinene Limonene Geraniol (trans)

Nerol (cis) Linalool Terpinen-4-ol α - Terpineol

Thymol 1,8-Cineol Borneol Camphor
(Eucalyptol)

√Ÿª∑’Ë 1 Ÿµ√‚§√ß √â“ߢÕß “√‡§¡’ª√–‡¿∑‡∑Õ√åªïπ å∫“ß™π‘¥∑’Ëæ∫„ππÈ”ÀÕ¡√–‡À¬