Page 43 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 3 ฉบับที่ 3
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«“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬å∑“߇≈◊Õ°                ªï∑’Ë Û ©∫—∫∑’Ë Û ¡‘∂ÿπ“¬π -°—𬓬π ÚıÙ¯ 41


               ¬“ ‡§√◊ËÕß ”Õ“ß ·≈–º≈‘µ¿—≥±å‡ √‘¡Õ“À“√ µ≈Õ¥®π°“√·æ∑¬å∑“߇≈◊Õ°Õ◊ËπÊ ‡™àπ  ÿ«§π∏∫”∫—¥

               (aromatherapy) °“√π«¥ ™à«¬°√–µÿâπ°“√‰À≈‡«’¬π¢Õß‚≈À‘µ ∑”„ÀâºàÕπ§≈“¬ ™à«¬„ÀâÀ≈—∫À√◊Õ ß∫
                                     2
               ®‘µ„® √–ß—∫°≈‘Ëπ ∑”„Àâ ¥™◊Ëπ  πÕ°®“°π’È ¡’√“¬ß“π∂÷ß°“√π”¡“„™âª√–‚¬™πå∑’ËÀ≈“°À≈“¬ µ—«Õ¬à“߇™àπ
                            1
                                                           3-9
               ƒ∑∏‘Ï¢—∫ªí  “«–  „™â‡æ◊ËÕªÑÕß°—π°”®—¥·¡≈ß∑“ß°“√·æ∑¬å  ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √– (free-radical scav-
                                                              12-20
                             10-11
               enging activity)  ƒ∑∏‘ϵâ“πÕÕ°´‘·¥π∑å (antioxidant)  ƒ∑∏‘ϵâ“π®ÿ≈‘π∑√’¬åÀ√◊Õ‡™◊ÈÕ√“À√◊Õ‡™◊ÈÕ
                   16-19
               ‰«√—   „π∑“߇§√◊ËÕß ”Õ“ßÕ“®„™âπÈ”¡—πÀÕ¡√–‡À¬‡æ◊ËÕ·µàß°≈‘Ëπ„ππÈ”ÀÕ¡ ‡æ‘Ë¡§«“¡™ÿà¡™◊Èπ·≈–§«“¡
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               ¬◊¥À¬ÿàπ¢Õߺ‘«Àπ—ß À√◊Õ‡æ‘Ë¡§«“¡‡ß“ß“¡‡ªìπª√–°“¬¢Õ߇ â㧭   ”À√—∫ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √–π—Èπ ¡’
               √“¬ß“π«à“ πÈ”¡—πÀÕ¡√–‡À¬∑’Ë¡’Õߧåª√–°Õ∫∑“߇§¡’‡ªìπ “√ª√–‡¿∑øï‚π≈‘°®–¡’ƒ∑∏‘Ï¥—ß°≈à“« ‡™àπ
               thymol, carvacrol, eugenol, carvone, thujone (¥Ÿ Ÿµ√‚§√ß √â“ß„π√Ÿª∑’Ë 1) Õ“®‡π◊ËÕß¡“®“° “√

               ª√–‡¿∑øï‚π≈‘°¡’§ÿ≥ ¡∫—µ‘„π°“√‡ªìπ “√µâ“πÕπÿ¡Ÿ≈Õ‘ √–‰¥â ‚¥¬°“√„À≌‚¥√‡®π Õ–µÕ¡°—∫ alkoxy
               radicals À√◊Õ peroxyl radicals º≈º≈‘µ∑’ˉ¥â§◊Õ Õπÿ¡Ÿ≈Õ‘ √– phenoxy ∑’Ë¡’§«“¡§ßµ—« Ÿß (‡π◊ËÕß¡“
               ®“°°“√¡’  delocalisation ¢ÕßÕ‘‡≈°µ√Õπ§Ÿà‚¥¥‡¥’ˬ«„π aromatic ring) ´÷Ëß®–‰ª≈¥°“√∑”
               ªØ‘°‘√‘¬“√–À«à“ßÕπÿ¡Ÿ≈Õ‘ √–°—∫‰¢¡—π (lipid peroxidation inhibition) πÕ°®“°π’È  À“°¡’
               °≈ÿࡉŒ¥√Õ°´’‡æ‘Ë¡¢÷Èπ∑’˵”·Àπàß ortho À√◊Õ para ¢Õß phenolic ring ®–¬‘Ë߇æ‘Ë¡ƒ∑∏‘ϵâ“πÕπÿ¡Ÿ≈Õ‘ √–

               ‡π◊ËÕß®“°‡°‘¥æ—π∏–‰Œ‚¥√‡®π¿“¬„π‚¡‡≈°ÿ≈ (intramolecular hydrogen-bonding)‹ ´÷Ëߙ૬„Àâ
               phenoxyl radicals ¡’§«“¡§ßµ—«¡“°¢÷Èπ 22-24









                               α - Pinene β - Pinene  Limonene     Geraniol (trans)











                                Nerol (cis)  Linalool  Terpinen-4-ol  α - Terpineol








                                 Thymol    1,8-Cineol   Borneol     Camphor
                                          (Eucalyptol)

                    √Ÿª∑’Ë 1  Ÿµ√‚§√ß √â“ߢÕß “√‡§¡’ª√–‡¿∑‡∑Õ√åªïπ å∫“ß™π‘¥∑’Ëæ∫„ππÈ”ÀÕ¡√–‡À¬
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