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               ABSTRACT

                        Ya-Kae Ka-Sai-Lin-Kra-Bue is one of the fourth Thai traditional recipes used
               for the treatment of Ka-Sai-Lin-Kra-Bue disease which may be caused by hepatitis,
               cirrhosis, hepatocellular carcinoma or cholecystitis. However, safety data of this traditional

               recipe had not yet been reported. Medicinal Plant Research Institute in cooperation with
               Institute of Thai Traditional Medicine investigated an acute and a ninety-day subchronic
               toxicity study of Ya-Kae Ka-Sai-Lin-Kra-Bue water extract by oral adminstration in

               Wistar rats.  It was found that the extract had LD  >8.0 g/kg and this dose did not cause
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               any acute toxic sign and abnormality of internal organs. Subchronic toxicity study of
               the extract was undertaken in six groups of rats (each of 15 male and 15 female) consisting

               of a water control group, four treatment groups receiving the extract at the doses of 0.5,
               2.5, 5.0 g/kg/day and a high recovery group receiving 5.0 g/kg/day for 90 day and
               followed by a 14-day of extract discontinuation respectively.  The extract did not affect

               average body weight, food consumption, health and general appearance of the animals.
               The significantly higher percentages of neutrophil in male rats treated with 2.5 and 5.0
               g/kg/day of extract were within normal range. Male rats receiving 5.0 g/kg/day extract
               had significantly lower serum potassium levels than their control group (p<0.05); however

               it was within normal range. Female rats receiving the highest dose of the extract had
               significantly higher sodium level but this change may be trivial and was within normal
               range. Taken together, the extract did not cause any abnormality in  hematological and

               clinical chemistry values. Gross pathology and histopathology of internal organs did not
               reveal any abnomality induced by the extract.
               Keywords: Ya-Kae-Ka-Sai-Lin-Kra-Bue, acute and chronic
               toxicity, Thai traditional recipe
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