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ABSTRACT

Ya-Kae Ka-Sai-Lin-Kra-Bue is one of the fourth Thai traditional recipes used
for the treatment of Ka-Sai-Lin-Kra-Bue disease which may be caused by hepatitis,
cirrhosis, hepatocellular carcinoma or cholecystitis. However, safety data of this traditional

recipe had not yet been reported. Medicinal Plant Research Institute in cooperation with
Institute of Thai Traditional Medicine investigated an acute and a ninety-day subchronic
toxicity study of Ya-Kae Ka-Sai-Lin-Kra-Bue water extract by oral adminstration in

Wistar rats. It was found that the extract had LD >8.0 g/kg and this dose did not cause
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any acute toxic sign and abnormality of internal organs. Subchronic toxicity study of
the extract was undertaken in six groups of rats (each of 15 male and 15 female) consisting

of a water control group, four treatment groups receiving the extract at the doses of 0.5,
2.5, 5.0 g/kg/day and a high recovery group receiving 5.0 g/kg/day for 90 day and
followed by a 14-day of extract discontinuation respectively. The extract did not affect

average body weight, food consumption, health and general appearance of the animals.
The significantly higher percentages of neutrophil in male rats treated with 2.5 and 5.0
g/kg/day of extract were within normal range. Male rats receiving 5.0 g/kg/day extract
had significantly lower serum potassium levels than their control group (p<0.05); however

it was within normal range. Female rats receiving the highest dose of the extract had
significantly higher sodium level but this change may be trivial and was within normal
range. Taken together, the extract did not cause any abnormality in hematological and

clinical chemistry values. Gross pathology and histopathology of internal organs did not
reveal any abnomality induced by the extract.
Keywords: Ya-Kae-Ka-Sai-Lin-Kra-Bue, acute and chronic
toxicity, Thai traditional recipe