Page 6 - Untitled-4

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Kaempferia parviflora Wall ex Bak. (KP) is now being popular for health

promotion. Up to the present time, toxicological information of this herb has been poorly
known. Oral acute toxicity study revealed that LD value of KP powder was more than
50
13.33 g/kg in mice and at this dose, no abnormal histopathological changes were found in
various visceral organs. Chronic toxicity study has been performed in six groups of Wistar

rats. Group 1 was a water control group and group 2 to 5 were orally given KP at the doses
of 20, 200, 1,000 and 2,000 mg/kg /day respectively. Group 6 was a high recovery group

which received 2000 mg/kg of KP and then KP was withdrawn for 2 weeks. The result
revealed that all KP-treated groups has no difference of body weight and health when
compared with their control group. Rats receiving 2000 mg/kg KP had some changes ; i.e.,
higher relative weight of liver (p<0.05) which might be due to lower body weight, less

eosinophil (p<0.05), higher serum sodium levels than their control groups (p<0.05) but
these were still within normal range. In addition female rats receiving the highest dose had
higher cholesterol level than the control group (p<0.05). Histopathological examination of

of visceral organs did not show any abnormality due to KP toxicity.

∫∑π” :

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