Page 38 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 2
P. 38
142 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë 11 ©∫—∫∑’Ë 2 情¿“§¡- ‘ßÀ“§¡ 2556
“√ °—¥ ¡ÿπ‰æ√∫“ß™π‘¥∫àß∂÷ß √√æ§ÿ≥„π°“√ ™‘ÈπÀ√◊ÕÕ«—¬«–¡“μ√«® ª√–°Õ∫°—∫μâÕß„™â«‘∏’°“√
ÕÕ°ƒ∑∏‘ÏμàÕ√–∫∫ª√– “∑ à«π°≈“ß ¥—ßπ—È𬓮÷ß °—¥ÕÕ°®“°Õ«—¬«–´÷Ëß´—∫´âÕπ°«à“„π‡≈◊Õ¥ ∑”„Àâ„π
§«√ºà“πμ—«°√Õß°—Èπ√–À«à“߇≈◊Õ¥·≈– ¡Õß (Blood ªí®®ÿ∫—π¬—ß¡’√“¬ß“π°“√»÷°…“∂÷ß√–¥—∫¬“„πÕ«—¬«–
brain barrier) ‡æ◊ËÕ‡¢â“ Ÿà®ÿ¥ÕÕ°ƒ∑∏‘Ï„π ¡Õß °“√ ·≈–‡π◊ÈÕ‡¬◊ËÕ®ÿ¥ÕÕ°ƒ∑∏‘ω¡à¡“°π—°
‡≈◊Õ°«—¥√–¥—∫¬“„πÕ«—¬«–·≈–‡π◊ÈÕ‡¬◊ËÕ∑’ˇ«≈“μà“ß°—π 3. °“√μ√«®«—¥À“‡¡·∑∫Õ‰≈μå∑’ˇ°‘¥¢÷Èπ®“°
¬àÕ¡ àߺ≈∂÷ߪ√‘¡“≥¬“∑’Ëμà“ß°—π¥â«¬ ®÷ߧ«√¡’°“√ “√ °—¥ ¡ÿπ‰æ√„π ‘Ëß¡’™’«‘μπ—Èπ Õ“®μâÕß„™â‡§√◊ËÕß
»÷°…“¡“°°«à“ 1 ®ÿ¥‡«≈“ ‡æ◊ËÕ¥Ÿ°“√‡ª≈’ˬπ·ª≈ß ¡◊Õ·≈–‚ª√·°√¡„π°“√§”π«≥À“§à“¡«≈‚¡‡≈°ÿ≈
¢Õß√–¥—∫¬“·≈–‡¡μ“∫Õ‰≈μå∑’ËÕ«—¬«–μà“ßÊ„π‡«≈“ ¢Õ߇¡μ“∫Õ‰≈μå∑’ˇ°‘¥¢÷Èπ ≥ ‡«≈“μà“ßÊ „π ‘Ëß¡’™’«‘μ
18,19
∑’Ë·μ°μà“ß°—𠇙à𠇧√◊ËÕß LC-MS ·≈–´Õøμå·«√å ∑’Ë¡’√“§“·æß
„πªí®®ÿ∫—π¡’‡æ’¬ß§≥–‡¿ —™»“ μ√å∫“ß·Ààß„π
√ÿª ∂“π°“√≥åªí®®ÿ∫—π·≈–·π«‚πâ¡°“√
ª√–‡∑»‰∑¬∑’Ë “¡“√∂∑”°“√»÷°…“‡À≈à“π’ȉ¥â
»÷°…“‡¿ —™®≈π»“ μ√å¢Õß “√ °—¥ ¡ÿπ‰æ√
¥—ßπ—Èπ·π«‚πâ¡°“√»÷°…“‡¿ —™®≈π»“ μ√å¢Õß
„πª√–‡∑»‰∑¬
“√ °—¥ ¡ÿπ‰æ√„πª√–‡∑»®÷ߧ«√¡’°“√æ—≤π“
„πªí®®ÿ∫—π‰¥â¡’√“¬ß“π°“√»÷°…“∑“߇¿ —™- §«“¡√à«¡¡◊Õ¢ÕßÀπ૬«‘®—¬®“°¡À“«‘∑¬“≈—¬μà“ßÊ
®≈π»“ μ√å¢Õß “√ °—¥ ¡ÿπ‰æ√∑’Ë ”§—≠„π ‡æ◊ËÕæ—≤π“¡“μ√∞“π°“√«‘®—¬„π°“√º≈‘μ·≈–æ—≤π“
ª√–‡∑»‰∑¬ ‚¥¬‡ªìπ°“√»÷°…“∑—Èß„π —μ«å∑¥≈Õß ¡ÿπ‰æ√„Àâ¡’§ÿ≥¿“æ·≈–¢âÕ¡Ÿ≈¬◊π¬—π∂÷ß
·≈–¡πÿ…¬å ´÷Ëß°“√∑¥≈Õß à«π„À≠à®–‡ªìπ°“√ ª√– ‘∑∏‘º≈·≈–§«“¡ª≈Õ¥¿—¬·°àºŸâ∫√‘‚¿§ ‡æ◊ËÕ„Àâ
∫√‘À“√¬“À√◊Õ “√ °—¥ ¡ÿπ‰æ√∑’Ë√Ÿâ‚§√ß √â“ß∑“߇§¡’ º≈‘μ¿—≥±å ¡ÿπ‰æ√‡À≈à“π’È “¡“√∂·¢àߢ—π‰¥â„π
‡™àπ ·Õπ‚¥√°√“‚ø‰≈¥å (Andrographolide) ®“° √–¥—∫π“π“™“μ‘μàÕ‰ª
øÑ“∑≈“¬‚®√ À√◊Õ “√ °—¥®“° ¡ÿπ‰æ√Õ◊ËπÊ ∑’Ëπ‘¬¡
20-22
„™â∑“ߧ≈‘π‘° Õ¬à“߉√°Áμ“¡√“¬ß“π°“√»÷°…“
‡À≈à“π’Èæ∫ªí≠À“ ”§—≠Õ¬Ÿà∫“ߪ√–°“√ §◊Õ ‡Õ° “√Õâ“ßÕ‘ß
1. °“√„™â‡§√◊ËÕß¡◊Õ«—¥ ‡™àπ HPLC-UV ‡æ◊ËÕ 1. Sribusarakum A, Yaithummasarn P, Chainok K,
Bunyapraphatsara N, Herunsalee A. A note on lactone
μ‘¥μ“¡À“√–¥—∫¬“„π‡≈◊Õ¥À≈—ß®“°∫√‘À“√¬“‰ª·≈â«
and andrographolide assays. «“√ “√ ¡ÿπ‰æ√ 2548;12(1):
ª√–¡“≥ 12-24 ™—Ë«‚¡ß √–¥—∫¬“„π‡≈◊Õ¥¡—°¡’§à“μË” 31-8.
≈ß„°≈⇧’¬ß°—∫§«“¡‡¢â¡¢âπμË” ÿ¥∑’ˇ§√◊ËÕß¡◊Õ 2. Kulyal P, Tiwari UK, Shukla A, Gaur AK. Chemical
constituents isolated from Andrographis paniculata. Indian
“¡“√∂«‘‡§√“–À剥â ∑”„Àâ¢âÕ¡Ÿ≈∑’ˉ¥â‚¥¬‡©æ“–§à“
Journal of Chemistry 2010;49B:356-9.
§√÷Ëß™’«‘μ¢Õß°“√°”®—¥¬“ÕÕ°®“°√à“ß°“¬Õ“®¡’ 3. National Toxicology Program. Summary of data for chemical
selection: Plumbagin. [Cited 2012 December 21]. Available
§«“¡§≈“¥‡§≈◊ËÕπ‰¥â Ÿß
from: http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/
2. °“√«—¥√–¥—∫¬“„πÕ«—¬«–·≈–‡π◊ÈÕ‡¬◊ËÕ∑’Ë®ÿ¥ exsumpdf/plumbagin.pdf
4. Stankovic I. Chemical and technical assessment: Curcumin.
ÕÕ°ƒ∑∏‘Ïπ—Èπ Õ“®‰¡à “¡“√∂∑”‰¥â„π¡πÿ…¬å·≈–„π
Food and Agriculture Organization 2004. [Cited 2012
°√≥’∑’Ë∑”„π —μ«å∑¥≈ÕßÕ“®μâÕß¡’°“√¶à“ —μ«å‡æ◊ËÕπ” December 21]. Available from: http://www.fao.org/