Page 59 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 10 ฉบับที่ 2 เสริม

50 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë 10 ©∫—∫∑’Ë 2 情¿“§¡- ‘ßÀ“§¡ (©∫—∫‡ √‘¡) 2555

PC-3

°“√‡μ√’¬¡‰¡‚§√Õ‘¡—≈™—π¢Õß “√ °—¥‚°∞‡™’¬ß (Angelica sinsensis)

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æ‘™¬“ Õÿ‚¶…Õ“√“¡‘° , √—∞æ≈ Õ“…“ ÿ®√‘μ , ª√– “π μ—È߬◊π¬ß«—≤π“

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§≥–°“√·æ∑¬å·ºπμ–«—πÕÕ° ¡À“«‘∑¬“≈—¬√—ß ‘μ
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“¢“«‘™“‡∑§‚π‚≈¬’‡¿ —™°√√¡ §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬»√’π§√‘π∑√«‘‚√≤

À≈—°°“√·≈–‡Àμÿº≈ ‚°∞‡™’¬ß (Angelica sinsensis) ‡ªìπæ◊™«ß»å Apiaceae ¡’ “√ ”§—≠∑’Ë¡’ƒ∑∏‘Ï∑“ß
‡¿ —™«‘∑¬“§◊Õ ferulic acid “√¥—ß°≈à“«¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √– μâ“π‡™◊ÈÕ®ÿ≈‘π∑√’¬å ·≈–μâ“π°“√Õ—°‡ ∫
ªí®®ÿ∫—π¡’°“√æ—≤π“º≈‘μ¿—≥±å∑“º‘«®“° “√ °—¥‚°∞‡™’¬ß‡æ◊ËÕ√—°…“¿“«–‡ âπ‡≈◊Õ¥¢Õ¥ ´÷Ëß à«π„À≠àÕ¬Ÿà„π√Ÿª
¢Õß “√≈–≈“¬ ß“π«‘®—¬π’È¡ÿàß∑’Ë®–æ—≤π“ “√ °—¥‚°∞‡™’¬ß„ÀâÕ¬Ÿà„π√Ÿª¢Õ߉¡‚§√Õ‘¡—≈™—π ´÷Ë߇ªìπ√–∫∫∑’Ë¡’≈—°…≥–„
«¬ß“¡ √«¡∑—È߬—ß “¡“√∂‡æ‘Ë¡°“√´÷¡ºà“πº‘«Àπ—ߢÕß “√ ”§—≠‰¥âÕ¬à“ß¡’ª√– ‘∑∏‘¿“æ ‡π◊ËÕß®“°¡’¢π“¥
Õπÿ¿“§∑’ˇ≈Á°Õ¬Ÿà„π™à«ß 10-100 π“‚π‡¡μ√ ‡À¡“–∑’Ë®–‡μ√’¬¡‡ªìπº≈‘μ¿—≥±å∑’Ë„™â°—∫º‘«Àπ—ß „πß“π«‘®—¬π’È

‡μ√’¬¡‰¡‚§√Õ‘¡—≈™—π‚¥¬„™â “√°àÕÕ‘¡—≈™—π (emulsifier) 2 ™π‘¥ §◊Õ cremophore RH40 À√◊Õ Tween 20
´÷Ë߇ªìπ “√≈¥·√ßμ÷ߺ‘«∑’Ë√“§“∂Ÿ°·≈–ª≈Õ¥¿—¬ ”À√—∫ºŸâ„™â
«—μ∂ÿª√– ß§å ‡æ◊ËÕ‡μ√’¬¡‰¡‚§√Õ‘¡—≈™—π¢Õß “√ °—¥‚°∞‡™’¬ß (Angelica sinsensis) ‚¥¬„™â cremophore
RH40 À√◊Õ Tween 20 ‡ªìπ “√°àÕÕ‘¡—≈™—π
«‘∏’¥”‡π‘π°“√ ‡μ√’¬¡ “√ °—¥¢Õß‚°∞‡™’¬ß ‚¥¬™—Ëߺ߂°∞‡™’¬ß∑’Ë∫¥≈–‡Õ’¬¥ 0.50 °°. À¡—°¥â«¬ 95%
‡Õ∏“πÕ≈ 1.5 ≈‘μ√‡ªìπ‡«≈“ 7 «—π °√Õß·≈–π”¡“√–‡À¬„Àâ·Àâߥ⫬ rotary evaporator ‰¥â “√ °—¥ 0.11 °°.
®“°π—Èπ®÷߇μ√’¬¡‰¡‚§√Õ‘¡—≈™—π‚¥¬„™â “√ °—¥‚°∞‡™’¬ß 1% º ¡°—∫«—Ø¿“§πÈ”¡—π‰¥â·°à clove oil, pepper-

mint oil, sage oil À√◊Õ neroli oil “√°àÕÕ‘¡—≈™—π‰¥â·°à cremophore RH40 À√◊Õ Tween 20 ·≈–πÈ”
·≈â«∫—π∑÷°≈—°…≥–¢Õߺ≈‘μ¿—≥±å∑’ˉ¥â≈ß„π ternary phase diagram ‡æ◊ËÕÀ“∫√‘‡«≥∑’ˇ°‘¥ isotropic liquid
®“°π—Èππ”‰¡‚§√Õ‘¡—≈™—π∑’ˉ¥â‰ª«—¥¢π“¥Õπÿ¿“§ ·≈–§à“»—°¬å‰øøÑ“´’μ“ ¥â«¬‡§√◊ËÕß zetasizer model S4700
(Malvern, UK)
º≈°“√»÷°…“ √–∫∫∑’Ë„™â peppermint oil À√◊Õ sage oil À√◊Õ neroli oil À√◊Õ clove oil ·≈– Tween
20 ®–„Àâæ◊Èπ∑’Ë∑’ˇ°‘¥‡ªìπ‰¡‚§√Õ‘¡—≈™—π ‡∑à“°—∫ 16, 18.3, 23.2 ·≈– 12.1% μ“¡≈”¥—∫ „π¢≥–∑’Ë cremophore
RH40 ®–„Àâæ◊Èπ∑’Ë isotropic liquid ‡∑à“°—∫ 8.1, 9.9, 7.2 ·≈– 17.4% μ“¡≈”¥—∫ ‡¡◊ËÕπ”μ—«Õ¬à“ß
‰¡‚§√Õ‘¡—≈™—π∑’Ë¡’Õߧåª√–°Õ∫ clove oil ´÷Ëß¡’§ÿ≥ ¡∫—μ‘„π°“√√—°…“¿“«–‡ âπ‡≈◊Õ¥¢Õ¥º ¡°—∫ “√ °—¥
‚°∞‡™’¬ß‚¥¬„™â√–∫∫ clove oil/cremophore RH40/H O (6 : 2 : 2) ·≈– clove oil/Tween 20 /H O
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(6 : 2 : 2) ¡“«—¥¢π“¥¥â«¬‡§√◊ËÕß zetasizer model S4700 ‰¥â§à“ 17.33 ± 0.58 π“‚π‡¡μ√ ·≈– 23 ± 1.0
π“‚π‡¡μ√ μ“¡≈”¥—∫ §à“»—°¬å‰øøÑ“´’쓇∑à“°—∫ -4.72 ± 0.52 ·≈– -2.1 ± 0.49 ¡‘≈≈‘‚«≈μå μ“¡≈”¥—∫
¢âÕ √ÿª °“√‡μ√’¬¡‰¡‚§√Õ‘¡—≈™—π¢Õß “√ °—¥‚°∞‡™’¬ß‡ªìπ«‘∏’∑’Ëßà“¬ “¡“√∂‡≈◊Õ°„™âπÈ”¡—π·≈– “√°àÕ
Õ‘¡—≈™—π‰¥âÀ≈“°À≈“¬ „π°√≥’¢Õß clove oil ‡¡◊ËÕπ”¡“‡μ√’¬¡‡ªìπ‰¡‚§√Õ‘¡—≈™—π®–‰¥â¢π“¥Õπÿ¿“§∑’ˇ≈Á°
√–¥—∫π“‚π‡¡μ√ ‡ªìπ°“√‡æ‘Ë¡»—°¬¿“æ„π°“√π” àß “√ °—¥‚°∞‡™’¬ßºà“πº‘«Àπ—߇æ◊ËÕ√—°…“¿“«–‡ âπ‡≈◊Õ¥¢Õ¥